PMID- 30360358
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 8
IP  - 4
DP  - 2018 Oct 22
TI  - Point-of-Care/Chairside aMMP-8 Analytics of Periodontal Diseases' Activity and 
      Episodic Progression.
LID - 10.3390/diagnostics8040074 [doi]
LID - 74
AB  - Traditional periodontal disease diagnostics are based mainly on clinical 
      examination and radiographs. They assess only past tissue destruction and provide 
      no information on the current disease status or its future progression. The 
      objective is to find out if an active matrix metalloproteinase-8 (aMMP-8) 
      point-of-care (PoC) test could provide a cost-effective way to get around this 
      limitation. This cross-sectional study used 47 adolescents and 70 adults, who 
      were clinically examined and their aMMP-8 PoC tested. The aMMP-8 PoC test results 
      and patients' treatment need, based on the community periodontal index of 
      treatment needs (CPITN), were compared and analyzed using Fisher's exact test. In 
      terms of CPITN, the aMMP-8 PoC test gave no false positives for both adolescents 
      and adults. All healthy patients got a negative test result, while a positive 
      test result indicated periodontal treatment need correctly. Finally, there was a 
      significant association between a patient's aMMP-8 PoC test result and his/her 
      treatment need (p = 0.001 for adolescents, p = 0.001 for adults). In conclusion, 
      more accurate diagnostics of periodontal diseases' activity and progression using 
      an aMMP-8 PoC test may help to reduce oral health care costs by reducing patient 
      overtreatment, improving patient outcome, and reducing the need for complex 
      periodontal therapy.
FAU - Raisanen, Ismo T
AU  - Raisanen IT
AUID- ORCID: 0000-0001-5821-5299
AD  - Department of Oral and Maxillofacial Diseases, Head and Neck Center, University 
      of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), 00014 
      Helsinki, Finland. ismo.raisanen@helsinki.fi.
FAU - Heikkinen, Anna Maria
AU  - Heikkinen AM
AD  - Department of Oral and Maxillofacial Diseases, Head and Neck Center, University 
      of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), 00014 
      Helsinki, Finland. anna.m.heikkinen@helsinki.fi.
FAU - Siren, Eva
AU  - Siren E
AD  - Department of Oral and Maxillofacial Diseases, Head and Neck Center, University 
      of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), 00014 
      Helsinki, Finland. eva.siren@helsinki.fi.
FAU - Tervahartiala, Taina
AU  - Tervahartiala T
AD  - Department of Oral and Maxillofacial Diseases, Head and Neck Center, University 
      of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), 00014 
      Helsinki, Finland. taina.tervahartiala@helsinki.fi.
FAU - Gieselmann, Dirk-Rolf
AU  - Gieselmann DR
AD  - Institute for Molecular Diagnostics (IMOD), Bonner Str. 84, 42697 Solingen, 
      Germany. gieselmann@matrix-lab.de.
FAU - van der Schoor, Gerrit-Jan
AU  - van der Schoor GJ
AD  - Division of Periodontology, Department of Dental Medicine, Karolinska Institute, 
      SE-171 77 Stockholm, Sweden. vdschoor.putten@gmail.com.
FAU - van der Schoor, Peter
AU  - van der Schoor P
AD  - Division of Periodontology, Department of Dental Medicine, Karolinska Institute, 
      SE-171 77 Stockholm, Sweden. peter@vanderschoor.org.
FAU - Sorsa, Timo
AU  - Sorsa T
AD  - Division of Periodontology, Department of Dental Medicine, Karolinska Institute, 
      SE-171 77 Stockholm, Sweden. timo.sorsa@helsinki.fi.
LA  - eng
GR  - TYH 2016251/Helsinki University Hospital Research Foundation/
GR  - TYH 2017251/Helsinki University Hospital Research Foundation/
GR  - TYH 2018229/Helsinki University Hospital Research Foundation/
GR  - Y1014SL017/Helsinki University Hospital Research Foundation/
GR  - Y1014SL018/Helsinki University Hospital Research Foundation/
GR  - -/Karolinska Institutet/
PT  - Journal Article
DEP - 20181022
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC6315514
OTO - NOTNLM
OT  - matrix metalloproteinases
OT  - periodontal diseases
OT  - periodontitis
OT  - point-of-care testing
COIS- Timo Sorsa is an inventor of US-patents 5652227, 5736341, 5866432, and 6143476. 
      Timo Sorsa and Dirk-Rolf Gieselmann are inventors of patent 20170023571. Other 
      authors report no conflict of interest.
EDAT- 2018/10/27 06:00
MHDA- 2018/10/27 06:01
PMCR- 2018/10/22
CRDT- 2018/10/27 06:00
PHST- 2018/09/27 00:00 [received]
PHST- 2018/10/15 00:00 [revised]
PHST- 2018/10/18 00:00 [accepted]
PHST- 2018/10/27 06:00 [entrez]
PHST- 2018/10/27 06:00 [pubmed]
PHST- 2018/10/27 06:01 [medline]
PHST- 2018/10/22 00:00 [pmc-release]
AID - diagnostics8040074 [pii]
AID - diagnostics-08-00074 [pii]
AID - 10.3390/diagnostics8040074 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2018 Oct 22;8(4):74. doi: 10.3390/diagnostics8040074.