PMID- 30360750
OWN - NLM
STAT- MEDLINE
DCOM- 20190618
LR  - 20190618
IS  - 2212-3873 (Electronic)
IS  - 1871-5303 (Linking)
VI  - 19
IP  - 2
DP  - 2019
TI  - IL-1beta and IL-1Ra Variant Profiles in Turkish Patients with Diabetic Peripheral 
      Neuropathy.
PG  - 150-158
LID - 10.2174/1871530318666181022165048 [doi]
AB  - BACKGROUND: Diabetic peripheral neuropathy (DPN) is one of the most common 
      complications of Type 2 diabetes mellitus (T2DM). This study was conducted to 
      investigate the possible association between interleukin-1beta (IL-1beta) rs16944 /IL-1 
      receptor antagonist (IL-1Ra) VNTR variants and genetic susceptibility to DPN in a 
      Turkish cohort. METHODS: A total of 200 subjects were enrolled in this study, 98 
      patients with DPN and 102 cases of age and sex-matched healthy controls. 
      Genotyping was performed for all individuals using PCR-RFLP analysis. RESULTS: 
      IL-1beta rs16944 CC genotype had a 3.20-fold increased risk for DPN (p=0.0003, 
      OR=3.20, 95% Cl:1.72-5.96). IL-1beta rs16944 CT genotype was higher in healthy 
      control than patients (p=0.004). IL-1beta rs16944 C allele was higher in the patient 
      group compared to controls while T allele was lower in patients than controls 
      (p=0.003). IL-1Ra VNTR a1/a1 and a2/a2 genotypes were lower in DPN patients while 
      a1/a2 genotype was higher in patients (p=0.045). The patients carrying a1/T 
      haplotype had decreased risk of DPN than control groups (p=0.004). The patients 
      carrying a2/a2 genotype had lower HDL level (p=0.039). The subjects carrying 
      a2/a2 genotype had higher total cholesterol level while the subjects carrying 
      a1/a2 genotype had lower total cholesterol (p=0.026 and p=0.037, respectively). 
      IL-1Ra a1 allele was associated with higher HDL level (p=0.041). CONCLUSION: 
      Findings of this study indicated that the IL-1beta rs16944 and IL-1Ra VNTR variants 
      are probably to be associated with susceptibility DPN risk in a Turkish cohort.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Nursal, Ayse Feyda
AU  - Nursal AF
AD  - Department of Medical Genetics, Faculty of Medicine, Hitit University, Corum, 
      Turkey; Department of Medical Genetics, Faculty of Medicine, Giresun University, 
      Giresun, Turkey.
FAU - Inanir, Ahmet
AU  - Inanir A
AD  - Academic Pain-Hernia Center, Samsun, Turkey.
FAU - Rustemoglu, Aydin
AU  - Rustemoglu A
AD  - Department of Medical Biology, Faculty of Medicine, Gaziosmanpasa University, 
      Tokat, Turkey.
FAU - Uzun, Suheyla
AU  - Uzun S
AD  - Department of Internal Medicine, Faculty of Medicine, Gaziosmanpasa University, 
      Tokat, Turkey.
FAU - Sahin, Kubra
AU  - Sahin K
AD  - Department of Medical Biology, Faculty of Medicine, Gaziosmanpasa University, 
      Tokat, Turkey.
FAU - Yigit, Serbulent
AU  - Yigit S
AD  - Department of Medical Biology, Faculty of Medicine, Gaziosmanpasa University, 
      Tokat, Turkey.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Endocr Metab Immune Disord Drug Targets
JT  - Endocrine, metabolic & immune disorders drug targets
JID - 101269157
RN  - 0 (IL1B protein, human)
RN  - 0 (IL1RN protein, human)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-1beta)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - DNA Mutational Analysis
MH  - Diabetes Mellitus, Type 2/complications/epidemiology/genetics
MH  - Diabetic Neuropathies/epidemiology/*genetics
MH  - Female
MH  - Genetic Linkage
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin 1 Receptor Antagonist Protein/*genetics
MH  - Interleukin-1beta/*genetics
MH  - Male
MH  - Middle Aged
MH  - Minisatellite Repeats/genetics
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Turkey/epidemiology
OTO - NOTNLM
OT  - DPN risk
OT  - IL-1Ra VNTR variants
OT  - Type 2 diabetes mellitus
OT  - diabetic peripheral neuropathy
OT  - interleukin-1Ra.
OT  - interleukin-1beta.
EDAT- 2018/10/27 06:00
MHDA- 2019/06/19 06:00
CRDT- 2018/10/27 06:00
PHST- 2018/02/17 00:00 [received]
PHST- 2018/10/06 00:00 [revised]
PHST- 2018/10/10 00:00 [accepted]
PHST- 2018/10/27 06:00 [pubmed]
PHST- 2019/06/19 06:00 [medline]
PHST- 2018/10/27 06:00 [entrez]
AID - EMIDDT-EPUB-93904 [pii]
AID - 10.2174/1871530318666181022165048 [doi]
PST - ppublish
SO  - Endocr Metab Immune Disord Drug Targets. 2019;19(2):150-158. doi: 
      10.2174/1871530318666181022165048.