PMID- 30361499
OWN - NLM
STAT- MEDLINE
DCOM- 20191018
LR  - 20191018
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Oct 25
TI  - Relationships between circulating branched chain amino acid concentrations and 
      risk of adverse cardiovascular events in patients with STEMI treated with PCI.
PG  - 15809
LID - 10.1038/s41598-018-34245-6 [doi]
LID - 15809
AB  - The incidence of in-hospital cardiovascular adverse events (AEs) in patients with 
      ST-segment elevation myocardial infarction (STEMI) following primary percutaneous 
      coronary intervention (PCI) is relatively high. Identification of metabolic 
      markers could improve our understanding of the underlying pathological changes in 
      these patients. We aimed to identify associations between concentrations of 
      plasma metabolites on admission and development of in-hospital AEs in post-PCI 
      patients with STEMI. We used targeted mass spectrometry to measure plasma 
      concentrations of 26 amino acid metabolites on admission in 96 patients with 
      STEMI who subsequently developed post-PCI AEs and in 96 age- and sex-matched 
      patients without post-PCI cardiovascular AEs. Principal component analysis (PCA) 
      revealed that PCA-derived factors, including branched chain amino acids (BCAAs), 
      were associated with increased risks of all three pre-specified outcomes: 
      cardiovascular mortality/acute heart failure (AHF), cardiovascular mortality, and 
      AHF. Addition of BCAA to the Global Registry of Acute Coronary Events risk score 
      increased the concordance C statistic from 0.702 to 0.814 (p < 0.001), and had a 
      net reclassification index of 0.729 (95% confidence interval, 0.466-0.992, 
      p < 0.001). These findings demonstrate that high circulating BCAA concentrations 
      on admission are associated with subsequent in-hospital AEs after 
      revascularization in patients with STEMI.
FAU - Du, Xiaoyu
AU  - Du X
AD  - First Hospital of Jilin University, Changchun, Jilin, 130021, China.
AD  - Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
FAU - You, Hongzhao
AU  - You H
AD  - Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
FAU - Li, Yulin
AU  - Li Y
AD  - Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
AD  - Key Laboratory of Remodelling-Related Cardiovascular Diseases, Ministry of 
      Education, Beijing, 100029, China.
FAU - Wang, Yuan
AU  - Wang Y
AD  - Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
AD  - Key Laboratory of Remodelling-Related Cardiovascular Diseases, Ministry of 
      Education, Beijing, 100029, China.
FAU - Hui, Peng
AU  - Hui P
AD  - First Hospital of Jilin University, Changchun, Jilin, 130021, China.
FAU - Qiao, Bokang
AU  - Qiao B
AD  - Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
AD  - Key Laboratory of Remodelling-Related Cardiovascular Diseases, Ministry of 
      Education, Beijing, 100029, China.
FAU - Lu, Jie
AU  - Lu J
AD  - Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
AD  - Key Laboratory of Remodelling-Related Cardiovascular Diseases, Ministry of 
      Education, Beijing, 100029, China.
FAU - Zhang, Weihua
AU  - Zhang W
AD  - First Hospital of Jilin University, Changchun, Jilin, 130021, China.
FAU - Zhou, Shanshan
AU  - Zhou S
AD  - First Hospital of Jilin University, Changchun, Jilin, 130021, China.
FAU - Zheng, Yang
AU  - Zheng Y
AD  - First Hospital of Jilin University, Changchun, Jilin, 130021, China. 
      zhengyang@jlu.edu.cn.
FAU - Du, Jie
AU  - Du J
AD  - Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. 
      jiedu@ccmu.edu.cn.
AD  - Key Laboratory of Remodelling-Related Cardiovascular Diseases, Ministry of 
      Education, Beijing, 100029, China. jiedu@ccmu.edu.cn.
LA  - eng
GR  - Z171100000417002/Beijing Council of Science and Technology/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181025
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Amino Acids, Branched-Chain/*blood
MH  - Biomarkers/blood
MH  - Female
MH  - Hospitals
MH  - Humans
MH  - Male
MH  - Metabolomics
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - Principal Component Analysis
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/*blood/*epidemiology
MH  - Treatment Outcome
PMC - PMC6202350
COIS- The authors declare no competing interests.
EDAT- 2018/10/27 06:00
MHDA- 2019/10/19 06:00
PMCR- 2018/10/25
CRDT- 2018/10/27 06:00
PHST- 2018/04/24 00:00 [received]
PHST- 2018/10/15 00:00 [accepted]
PHST- 2018/10/27 06:00 [entrez]
PHST- 2018/10/27 06:00 [pubmed]
PHST- 2019/10/19 06:00 [medline]
PHST- 2018/10/25 00:00 [pmc-release]
AID - 10.1038/s41598-018-34245-6 [pii]
AID - 34245 [pii]
AID - 10.1038/s41598-018-34245-6 [doi]
PST - epublish
SO  - Sci Rep. 2018 Oct 25;8(1):15809. doi: 10.1038/s41598-018-34245-6.