PMID- 3036186
OWN - NLM
STAT- MEDLINE
DCOM- 19870805
LR  - 20041117
IS  - 0252-1172 (Print)
IS  - 0252-1172 (Linking)
VI  - 4
IP  - 3
DP  - 1986
TI  - Neuroendocrine structures in normal and diseased human lung.
PG  - 147-61
AB  - The increasing amount of histological, immunohistochemical and ultrastructural 
      information on some endocrine secretions in human lung cancers suggest the need 
      to revise the classification of neuroendocrine lesions on surgical material. The 
      aim of the present investigation based on lung specimens removed surgically is to 
      give further support to recent proposal for an updated classification of 
      neuroendocrine lung carcinomas. Our study includes 58 squamous cell carcinomas, 
      58 adenocarcinomas, 6 large cell carcinomas, 27 neuroendocrine carcinomas, and 30 
      nontumourous cases. Using histological methods (HE, Alcian PAS, Grimelius silver 
      impregnation), we illustrate the presence of neuroendocrine cells and 
      neuroepithelial bodies with their pathological evolutions, ranging from 
      hyperplasia, to dysplasia, and overt neoplasia. On the basis of our experience we 
      propose the following classification of neuroendocrine carcinomas (NEC): typical 
      carcinoids (NECNID), peripheral carcinoid or well-differentiated NEC (NECWED), 
      NEC of intermediate or poorly differentiated type (NECINT) and NEC of small 
      celled or microcytoma type (NECMIC).
FAU - Mosca, L
AU  - Mosca L
FAU - Ceresoli, A
AU  - Ceresoli A
FAU - Anzanello, E
AU  - Anzanello E
FAU - Mauri, F
AU  - Mauri F
FAU - Mariscotti, C
AU  - Mariscotti C
FAU - Timossi, R
AU  - Timossi R
FAU - Barbareschi, M
AU  - Barbareschi M
FAU - Mezzetti, M
AU  - Mezzetti M
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Appl Pathol
JT  - Applied pathology
JID - 8308921
SB  - IM
MH  - Adenocarcinoma/pathology
MH  - Carcinoid Tumor/pathology
MH  - Carcinoma, Small Cell/pathology
MH  - Carcinoma, Squamous Cell/pathology
MH  - Humans
MH  - Lung/*pathology
MH  - Lung Neoplasms/classification/*pathology
MH  - Neurosecretory Systems/*pathology
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
PST - ppublish
SO  - Appl Pathol. 1986;4(3):147-61.