PMID- 30362359
OWN - NLM
STAT- MEDLINE
DCOM- 20191021
LR  - 20191022
IS  - 1130-0108 (Print)
IS  - 1130-0108 (Linking)
VI  - 110
IP  - 12
DP  - 2018 Dec
TI  - Appropriateness of the use of proton pump inhibitors in the Emergency Department 
      of a Spanish university hospital.
PG  - 755-761
LID - 10.17235/reed.2018.5468/2018 [doi]
AB  - BACKGROUND: the use of proton pump inhibitors (PPI) has increased substantially 
      during the last years, possibly due to a significant proportion of prescriptions 
      that do not follow the approved indications. OBJECTIVE: to assess the prevalence 
      of PPI prescription and the appropriateness of the prescription within the 
      Emergency Department (ED) of a Spanish university hospital. MATERIALS AND 
      METHODS: a cross-sectional, retrospective prescription-indication drug-use study 
      was performed, which selected 384 patients that presented to the ED over two days 
      in January 2016. RESULTS: of the total cohort, 23.2% were taking PPI before their 
      hospital visit and only 20.2% had a correct indication and dosage; 2.9% of the 
      patient cohort had an indication for PPI treatment but had not been prescribed 
      them. A drug other than omeprazole was used in 25% of cases; 30.47% of the 
      patients were discharged with a PPI and only 28.2% of them had the correct 
      indication and dosage. Finally, 5.7% were not prescribed PPI even though it was 
      warranted. PPI prescription increased with age whereas the indication for the 
      prescription decreased. Furthermore, the use of these drugs was higher in 
      hospitalized patients compared to discharged patients. CONCLUSIONS: these results 
      are in line with similar studies, which demonstrate the existence of an 
      over-prescription of PPI. PPI prescription needs to be improved, thereby reducing 
      drug interactions, adverse effects and unnecessary economical expenses.
FAU - Granero-Melcon, Beatriz
AU  - Granero-Melcon B
AUID- ORCID: 0000-0001-8525-5405
AD  - Pharmacology, Universidad Autonoma de Madrid, Espana.
FAU - Morras, Ignacio
AU  - Morras I
AD  - Hospital Puerta de Hierro Majadahonda.
FAU - Galan-DeJuana, Miguel
AU  - Galan-DeJuana M
AD  - Universidad Autonoma de Madrid.
FAU - Abad-Santos, Francisco
AU  - Abad-Santos F
AD  - Universidad Autonoma de Madrid.
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Rev Esp Enferm Dig
JT  - Revista espanola de enfermedades digestivas
JID - 9007566
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Emergency Service, Hospital
MH  - Emergency Treatment/*statistics & numerical data
MH  - Female
MH  - Hospitals, University
MH  - Humans
MH  - Inappropriate Prescribing/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Spain
MH  - Young Adult
EDAT- 2018/10/27 06:00
MHDA- 2019/10/23 06:00
CRDT- 2018/10/27 06:00
PHST- 2018/10/27 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
PHST- 2018/10/27 06:00 [entrez]
AID - 10.17235/reed.2018.5468/2018 [doi]
PST - ppublish
SO  - Rev Esp Enferm Dig. 2018 Dec;110(12):755-761. doi: 10.17235/reed.2018.5468/2018.