PMID- 30362975
OWN - NLM
STAT- MEDLINE
DCOM- 20200619
LR  - 20200619
IS  - 1473-5709 (Electronic)
IS  - 0959-8278 (Linking)
VI  - 28
IP  - 4
DP  - 2019 Jul
TI  - Persistent organic pollutants, pesticides, and the risk of thyroid cancer: 
      systematic review and meta-analysis.
PG  - 344-349
LID - 10.1097/CEJ.0000000000000481 [doi]
AB  - Previous epidemiological studies have reported persistent organic pollutants 
      (POPs) and some nonpersistent pesticides and the risk of thyroid cancer. The aim 
      of this study was to assess the association between exposure to POPs, pesticides, 
      and thyroid cancer by carrying out a meta-analysis. Literature searches were 
      performed using PubMed, Embase, and reference lists of relevant articles. Summary 
      risk estimates for thyroid cancer were calculated using fixed-effects and 
      random-effects models. In addition, several subgroup and sensitivity analyses 
      were carried out. Fifteen studies were reviewed, and eight studies were included 
      in the meta-analysis. Pesticide exposure showed positive, statistically 
      significant associations with thyroid cancer [odds ratio (OR)=1.48, 95% 
      confidence interval (CI)=1.15-1.91, I=48%, Pheterogenetiy=0.05]. After subgroup 
      analysis, herbicide exposure (OR=3.00, 95% CI=1.38-6.54) and agricultural 
      exposure to pesticides (OR=1.86, 95% CI=1.04-3.32) was associated with an 
      increased risk of thyroid cancer. A sensitivity analysis showed that the results 
      were robust. Exposure to pesticides was associated with an increased risk of 
      thyroid cancer in this meta-analysis. Future studies should investigate exposure 
      to POPs or pesticides with controls for potential confounders using biological 
      samples.
FAU - Han, Mi Ah
AU  - Han MA
AD  - Departments of Preventive Medicine.
FAU - Kim, Jin Hwa
AU  - Kim JH
AD  - Internal Medicine.
FAU - Song, Han Soo
AU  - Song HS
AD  - Internal Medicine.
AD  - Occupational and Environmental Medicine, College of Medicine, Chosun University, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
PL  - England
TA  - Eur J Cancer Prev
JT  - European journal of cancer prevention : the official journal of the European 
      Cancer Prevention Organisation (ECP)
JID - 9300837
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
RN  - 0 (Pesticides)
SB  - IM
MH  - Confounding Factors, Epidemiologic
MH  - Environmental Exposure/*adverse effects/prevention & control
MH  - Environmental Pollutants/*toxicity
MH  - Global Burden of Disease
MH  - Humans
MH  - Incidence
MH  - Odds Ratio
MH  - Organic Chemicals/*toxicity
MH  - Pesticides/*toxicity
MH  - Risk Factors
MH  - Thyroid Neoplasms/*epidemiology/etiology/prevention & control
EDAT- 2018/10/27 06:00
MHDA- 2020/06/20 06:00
CRDT- 2018/10/27 06:00
PHST- 2018/10/27 06:00 [pubmed]
PHST- 2020/06/20 06:00 [medline]
PHST- 2018/10/27 06:00 [entrez]
AID - 10.1097/CEJ.0000000000000481 [doi]
PST - ppublish
SO  - Eur J Cancer Prev. 2019 Jul;28(4):344-349. doi: 10.1097/CEJ.0000000000000481.