PMID- 3036335
OWN - NLM
STAT- MEDLINE
DCOM- 19870813
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 60
IP  - 3 Suppl
DP  - 1987 Aug 1
TI  - The treatment of advanced or recurrent malignant genitourinary tumors in 
      children.
PG  - 602-11
AB  - Wilms' tumor, embryonal rhabdomyosarcoma, and yolk sac tumor are the most 
      frequently diagnosed malignant genitourinary tumors in children. The randomized 
      therapeutic trials developed by the National Wilms' Tumor Study (NWTS) committee 
      have produced significant improvements in the survival of Wilms' tumor patients. 
      Those with Stage IV, favorable histology Wilms' tumor now have a 2-year survival 
      rate of 87% to 93%. Patients with recurrent Wilms' tumor are being prospectively 
      treated with new drugs and drug combinations with the goal of identifying active 
      agents for inclusion in future therapeutic trials. Girls with localized embryonal 
      rhabdomyosarcoma of the vagina have a 100% survival rate after treatment on the 
      Intergroup Rhabdomyosarcoma Study (IRS) (IRS-1 or IRS-2). Primary treatment of 
      patients with tumors of the prostate, bladder neck, or trigone with chemotherapy 
      has demonstrated the need to establish local tumor control using surgery or 
      radiation soon after diagnosis. The IRS-III currently is evaluating new drug 
      combinations in this group of patients with locally advanced tumors. Patients 
      with advanced yolk sac tumor have been treated using platinum-containing 
      combination chemotherapy regimens with very encouraging results. Future research 
      will evaluate the timing of second-look surgical procedures and the efficacy of 
      etoposide-containing combination chemotherapy regimens.
FAU - Green, D M
AU  - Green DM
LA  - eng
GR  - CA 11722/CA/NCI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Child
MH  - Clinical Trials as Topic
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Infant
MH  - Laparotomy
MH  - Male
MH  - Mesonephroma/therapy
MH  - Neoplasm Metastasis
MH  - Neoplasm Recurrence, Local/therapy
MH  - Random Allocation
MH  - Rhabdomyosarcoma/therapy
MH  - Urogenital Neoplasms/*therapy
MH  - Wilms Tumor/therapy
RF  - 51
EDAT- 1987/08/01 00:00
MHDA- 1987/08/01 00:01
CRDT- 1987/08/01 00:00
PHST- 1987/08/01 00:00 [pubmed]
PHST- 1987/08/01 00:01 [medline]
PHST- 1987/08/01 00:00 [entrez]
AID - 10.1002/1097-0142(19870801)60:3+<602::aid-cncr2820601527>3.0.co;2-d [doi]
PST - ppublish
SO  - Cancer. 1987 Aug 1;60(3 Suppl):602-11. doi: 
      10.1002/1097-0142(19870801)60:3+<602::aid-cncr2820601527>3.0.co;2-d.