PMID- 30363988
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20230928
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2018
DP  - 2018
TI  - New Insights into the Role of Exercise in Inhibiting mTOR Signaling in 
      Triple-Negative Breast Cancer.
PG  - 5896786
LID - 10.1155/2018/5896786 [doi]
LID - 5896786
AB  - Triple-negative breast cancer (TNBC) does not express estrogen receptor, 
      progesterone receptor, and human epidermal growth factor receptor 2 and is 
      characterized by its aggressive nature, lack of targets for targeted therapies, 
      and early peak of recurrence. Due to these specific characteristics, chemotherapy 
      does not usually yield substantial improvements and new target therapies and 
      alternative strategies are needed. The beneficial responses of TNBC survivors to 
      regular exercise, including a reduction in the rate of tumor growth, are becoming 
      increasingly apparent. Physiological adaptations to exercise occur in skeletal 
      muscle but have an impact on the entire body through systemic control of energy 
      homeostasis and metabolism, which in turn influence the TNBC tumor 
      microenvironment. Gaining insights into the causal mechanisms of the therapeutic 
      cancer control properties of regular exercise is important to improve the 
      prescription and implementation of exercise and training in TNBC survivors. Here, 
      we provide new evidence of the effects of exercise on TNBC prevention, control, 
      and outcomes, based on the inhibition of the phosphatidylinositol-3-kinase 
      (PI3K)/protein kinase B (PKB also known as Akt)/mammalian target of rapamycin 
      (mTOR) (PI3K-Akt-mTOR) signaling. These findings have wide-ranging clinical 
      implications for cancer treatment, including recurrence and case management.
FAU - Agostini, Deborah
AU  - Agostini D
AUID- ORCID: 0000-0003-0225-666X
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 
      Italy.
FAU - Natalucci, Valentina
AU  - Natalucci V
AUID- ORCID: 0000-0002-0582-1575
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 
      Italy.
FAU - Baldelli, Giulia
AU  - Baldelli G
AUID- ORCID: 0000-0001-8254-2994
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 
      Italy.
FAU - De Santi, Mauro
AU  - De Santi M
AUID- ORCID: 0000-0003-2983-8344
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 
      Italy.
FAU - Donati Zeppa, Sabrina
AU  - Donati Zeppa S
AUID- ORCID: 0000-0001-5879-0752
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 
      Italy.
FAU - Vallorani, Luciana
AU  - Vallorani L
AUID- ORCID: 0000-0002-0858-6275
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 
      Italy.
FAU - Annibalini, Giosue
AU  - Annibalini G
AUID- ORCID: 0000-0002-6914-4905
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 
      Italy.
FAU - Lucertini, Francesco
AU  - Lucertini F
AUID- ORCID: 0000-0003-3134-4511
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 
      Italy.
FAU - Federici, Ario
AU  - Federici A
AUID- ORCID: 0000-0003-0878-4949
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 
      Italy.
FAU - Izzo, Riccardo
AU  - Izzo R
AUID- ORCID: 0000-0001-7184-7389
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 
      Italy.
FAU - Stocchi, Vilberto
AU  - Stocchi V
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 
      Italy.
FAU - Barbieri, Elena
AU  - Barbieri E
AUID- ORCID: 0000-0002-3480-7983
AD  - Interuniversity Institute of Myology (IIM), University of Urbino Carlo Bo, 61029 
      Urbino, PU, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180930
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Autophagy
MH  - Energy Intake
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Triple Negative Breast Neoplasms/*metabolism/*physiopathology
PMC - PMC6186337
EDAT- 2018/10/27 06:00
MHDA- 2018/11/27 06:00
PMCR- 2018/09/30
CRDT- 2018/10/27 06:00
PHST- 2018/04/13 00:00 [received]
PHST- 2018/08/03 00:00 [revised]
PHST- 2018/08/12 00:00 [accepted]
PHST- 2018/10/27 06:00 [entrez]
PHST- 2018/10/27 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/09/30 00:00 [pmc-release]
AID - 10.1155/2018/5896786 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2018 Sep 30;2018:5896786. doi: 10.1155/2018/5896786. 
      eCollection 2018.