PMID- 30364132
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 8
DP  - 2018
TI  - Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of 
      Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic 
      Cancer Cells.
PG  - 376
LID - 10.3389/fonc.2018.00376 [doi]
LID - 376
AB  - The ATP-binding cassette transporter G1 (ABCG1) is a cholesterol lipid efflux 
      pump whose role in tumor growth has been largely unknown. Our transcriptomics 
      revealed that ABCG1 was powerfully expressed in rapidly metastatic, aggregative 
      colon cancer cells, in all the ABC transporter family members. Coincidently, 
      genetic amplification of ABCG1 is found in 10-35% of clinical samples of 
      metastatic cancer cases. Expression of ABCG1 was further elevated in 
      three-dimensional tumoroids (tumor organoids) within stemness-enhancing tumor 
      milieu, whereas depletion of ABCG1 lowered cellular aggregation and tumoroid 
      growth in vitro as well as hypoxia-inducible factor 1alpha in cancer cells around the 
      central necrotic areas in tumors in vivo. Notably, depletion of ABCG1 triggered 
      the intracellular accumulation of extracellular vesicles (EVs) and regression of 
      tumoroids. Collectively, these data suggest that ABCG1 plays a crucial role in 
      tumorigenesis in metastatic cancer and that depletion of ABCG1 triggers tumor 
      regression with the accumulation of EVs and their derivatives and cargos, 
      implicating a novel ABCG1-targeting therapeutic strategy by which redundant and 
      toxic substances may be accumulated in tumors leading to their regression.
FAU - Namba, Yuri
AU  - Namba Y
AD  - Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and 
      Pharmaceutical Sciences, Okayama University, Okayama, Japan.
AD  - Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, 
      Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
FAU - Sogawa, Chiharu
AU  - Sogawa C
AD  - Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and 
      Pharmaceutical Sciences, Okayama University, Okayama, Japan.
FAU - Okusha, Yuka
AU  - Okusha Y
AD  - Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and 
      Pharmaceutical Sciences, Okayama University, Okayama, Japan.
FAU - Kawai, Hotaka
AU  - Kawai H
AD  - Department of Oral Pathology and Medicine, Graduate School of Medicine, 
      Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
FAU - Itagaki, Mami
AU  - Itagaki M
AD  - Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and 
      Pharmaceutical Sciences, Okayama University, Okayama, Japan.
FAU - Ono, Kisho
AU  - Ono K
AD  - Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and 
      Pharmaceutical Sciences, Okayama University, Okayama, Japan.
FAU - Murakami, Jun
AU  - Murakami J
AD  - Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of 
      Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, 
      Japan.
AD  - Department of Oral Diagnosis and Dentomaxillofacial Radiology, Okayama University 
      Hospital, Okayama, Japan.
FAU - Aoyama, Eriko
AU  - Aoyama E
AD  - Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of 
      Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, 
      Japan.
FAU - Ohyama, Kazumi
AU  - Ohyama K
AD  - Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and 
      Pharmaceutical Sciences, Okayama University, Okayama, Japan.
FAU - Asaumi, Jun-Ichi
AU  - Asaumi JI
AD  - Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, 
      Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
FAU - Takigawa, Masaharu
AU  - Takigawa M
AD  - Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of 
      Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, 
      Japan.
FAU - Okamoto, Kuniaki
AU  - Okamoto K
AD  - Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and 
      Pharmaceutical Sciences, Okayama University, Okayama, Japan.
FAU - Calderwood, Stuart K
AU  - Calderwood SK
AD  - Division of Molecular and Cellular Biology, Department of Radiation Oncology, 
      Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United 
      States.
FAU - Kozaki, Ken-Ichi
AU  - Kozaki KI
AD  - Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and 
      Pharmaceutical Sciences, Okayama University, Okayama, Japan.
FAU - Eguchi, Takanori
AU  - Eguchi T
AD  - Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and 
      Pharmaceutical Sciences, Okayama University, Okayama, Japan.
AD  - Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of 
      Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20181010
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC6191470
OTO - NOTNLM
OT  - ABCG transporter
OT  - ABCG1
OT  - extracellular vesicle
OT  - hypoxia
OT  - metastatic cancer
OT  - tumoroids
EDAT- 2018/10/27 06:00
MHDA- 2018/10/27 06:01
PMCR- 2018/01/01
CRDT- 2018/10/27 06:00
PHST- 2018/04/08 00:00 [received]
PHST- 2018/08/22 00:00 [accepted]
PHST- 2018/10/27 06:00 [entrez]
PHST- 2018/10/27 06:00 [pubmed]
PHST- 2018/10/27 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2018.00376 [doi]
PST - epublish
SO  - Front Oncol. 2018 Oct 10;8:376. doi: 10.3389/fonc.2018.00376. eCollection 2018.