PMID- 30364485
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 1849-4544 (Electronic)
IS  - 1849-4544 (Linking)
VI  - 7
DP  - 2018 Jan-Dec
TI  - Assessment of brain-derived neurotrophic factor and osteopontin in a healthy 
      pediatric population.
PG  - 1849454418806136
LID - 10.1177/1849454418806136 [doi]
LID - 1849454418806136
AB  - Biomarkers are routinely used for noninvasive identification or monitoring of 
      disease processes in clinical practice, as well as surrogate end points for drug 
      development. There is a significant lack of data regarding biomarkers in 
      children. An understanding of biomarker levels in a healthy pediatric cohort is 
      essential as more studies begin to apply noninvasive biomarkers to pediatric 
      populations. Brain-derived neurotrophic factor (BDNF) functions in neuronal 
      survival and plasticity and is associated with exercise capacity and inflammatory 
      disease processes. Osteopontin (OPN) plays a regulatory role in inflammation and 
      may be a clinically useful biomarker of cardiovascular disease processes, 
      ventricular remodeling, and skeletal muscle regeneration. This study describes 
      our initial experience with a cohort of healthy pediatric patients and seeks to 
      provide normal values of BDNF and OPN with correlation to age, gender, and 
      cardiovascular and fitness measures. Serum BDNF and plasma OPN were measured 
      using enzyme-linked immunosorbent assay in 33 healthy pediatric subjects. 
      Subjects underwent complete cardiac evaluation, including echocardiography, 
      exercise stress testing, and health risk assessment. The 5th-95th percentile was 
      5.63-37.86 ng/ml for serum BDNF and 4.9-164.9 ng/ml for plasma OPN. Plasma OPN 
      correlated with number of days of exercise per week (r = 0.46, p = 0.008). No 
      other correlations were significant. This study provides the initial data on 
      serum BDNF and plasma OPN in children and begins to explore the relationships of 
      BDNF and OPN to cardiovascular health and fitness in the pediatric population.
FAU - Chew, Joshua D
AU  - Chew JD
AUID- ORCID: 0000-0003-3955-7386
AD  - Thomas P. Graham Division of Pediatric Cardiology, Department of Pediatrics, 
      Vanderbilt University Medical Center, Nashville, TN, USA.
FAU - Markham, Larry
AU  - Markham L
AD  - Thomas P. Graham Division of Pediatric Cardiology, Department of Pediatrics, 
      Vanderbilt University Medical Center, Nashville, TN, USA.
FAU - Smith, Holly M
AU  - Smith HM
AD  - Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt 
      University Medical Center, Nashville, TN, USA.
FAU - Su, Yan Ru
AU  - Su YR
AD  - Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt 
      University Medical Center, Nashville, TN, USA.
FAU - Tomasek, Kelsey
AU  - Tomasek K
AD  - Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt 
      University Medical Center, Nashville, TN, USA.
FAU - Slaughter, James C
AU  - Slaughter JC
AD  - Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, 
      USA.
FAU - Sawyer, Douglas
AU  - Sawyer D
AD  - Division of Cardiovascular Services, Maine Medical Center, Portland, ME, USA.
FAU - Soslow, Jonathan H
AU  - Soslow JH
AD  - Thomas P. Graham Division of Pediatric Cardiology, Department of Pediatrics, 
      Vanderbilt University Medical Center, Nashville, TN, USA.
LA  - eng
GR  - K23 HL123938/HL/NHLBI NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - UL1 TR000445/TR/NCATS NIH HHS/United States
GR  - UL1 TR002243/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20181018
PL  - United States
TA  - J Circ Biomark
JT  - Journal of circulating biomarkers
JID - 101703517
PMC - PMC6196610
OTO - NOTNLM
OT  - Pediatric
OT  - biomarker
OT  - brain-derived neurotrophic factor
OT  - cardiovascular
OT  - osteopontin
OT  - reference range
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2018/10/27 06:00
MHDA- 2018/10/27 06:01
PMCR- 2018/10/18
CRDT- 2018/10/27 06:00
PHST- 2018/02/26 00:00 [received]
PHST- 2018/09/10 00:00 [accepted]
PHST- 2018/10/27 06:00 [entrez]
PHST- 2018/10/27 06:00 [pubmed]
PHST- 2018/10/27 06:01 [medline]
PHST- 2018/10/18 00:00 [pmc-release]
AID - 10.1177_1849454418806136 [pii]
AID - 10.1177/1849454418806136 [doi]
PST - epublish
SO  - J Circ Biomark. 2018 Oct 18;7:1849454418806136. doi: 10.1177/1849454418806136. 
      eCollection 2018 Jan-Dec.