PMID- 30365389
OWN - NLM
STAT- MEDLINE
DCOM- 20190823
LR  - 20190823
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 81
IP  - 20
DP  - 2018
TI  - Reverse dosimetry modeling of toluene exposure concentrations based on 
      biomonitoring levels from the Canadian health measures survey.
PG  - 1066-1082
LID - 10.1080/15287394.2018.1534174 [doi]
AB  - Biomonitoring might provide useful estimates of population exposure to 
      environmental chemicals. However, data uncertainties stemming from 
      interindividual variability are common in large population biomonitoring surveys. 
      Physiologically based pharmacokinetic (PBPK) models might be used to account for 
      age- and gender-related variability in internal dose. The objective of this study 
      was to reconstruct air concentrations consistent with blood toluene measures 
      reported in the third Canadian Health Measures Survey using reverse dosimetry 
      PBPK modeling techniques. Population distributions of model's physiological 
      parameters were described based upon age, weight, and size for four 
      subpopulations (12-19, 20-39, 40-59, and 60-79 years old). Monte Carlo 
      simulations applied to PBPK modeling allowed converting the distributions of 
      venous blood measures of toluene obtained from CHMS into related air levels. 
      Based upon blood levels observed at the 50(th), 90(th) and 95(th) percentiles, 
      corresponding air toluene concentrations were estimated for teenagers aged 
      12-19 years as being, respectively, 0.009, 0.04 and 0.06 ppm. Similarly, values 
      were computed for adults aged 20-39 years (0.007, 0.036, and 0.06 ppm), 
      40-59 years (0.007, 0.036 and 0.06 ppm) and 60-79 years (0.006, 0.022 and 0.04 
      ppm). These estimations are well below Health Canada's maximum recommended 
      chronic air guidelines for toluene. In conclusion, PBPK modeling and reverse 
      dosimetry may be combined to help interpret biomonitoring data for chemical 
      exposure in large population surveys and estimate the associated toxicological 
      health risk.
FAU - Tohon, Honesty
AU  - Tohon H
AD  - a Department of Environmental and Occupational Health , ESPUM, IRSPUM, Universite 
      de Montreal , Montreal , (Qc.) , Canada.
FAU - Nong, Andy
AU  - Nong A
AD  - b Exposure and Biomonitoring Division , Environmental Health Sciences and 
      Research Bureau, Health Canada , Ottawa , ON , Canada.
FAU - Moreau, Marjory
AU  - Moreau M
AD  - b Exposure and Biomonitoring Division , Environmental Health Sciences and 
      Research Bureau, Health Canada , Ottawa , ON , Canada.
FAU - Valcke, Mathieu
AU  - Valcke M
AD  - a Department of Environmental and Occupational Health , ESPUM, IRSPUM, Universite 
      de Montreal , Montreal , (Qc.) , Canada.
AD  - c Direction de la sante environnementale et de la toxicologie , Institut national 
      de sante publique du Quebec , Montreal , Quebec , Canada.
FAU - Haddad, Sami
AU  - Haddad S
AUID- ORCID: 0000-0001-8906-9693
AD  - a Department of Environmental and Occupational Health , ESPUM, IRSPUM, Universite 
      de Montreal , Montreal , (Qc.) , Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181026
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Environmental Pollutants)
RN  - 3FPU23BG52 (Toluene)
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Canada
MH  - Environmental Monitoring/*methods
MH  - Environmental Pollutants/*pharmacokinetics
MH  - Health Surveys
MH  - Humans
MH  - Middle Aged
MH  - Models, Biological
MH  - Monte Carlo Method
MH  - Toluene/*pharmacokinetics
MH  - Young Adult
OTO - NOTNLM
OT  - Biomonitoring
OT  - CHMS
OT  - PBPK modeling
OT  - Reverse Dosimetry
OT  - Toluene
EDAT- 2018/10/27 06:00
MHDA- 2019/08/24 06:00
CRDT- 2018/10/27 06:00
PHST- 2018/10/27 06:00 [pubmed]
PHST- 2019/08/24 06:00 [medline]
PHST- 2018/10/27 06:00 [entrez]
AID - 10.1080/15287394.2018.1534174 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2018;81(20):1066-1082. doi: 
      10.1080/15287394.2018.1534174. Epub 2018 Oct 26.