PMID- 30367528
OWN - NLM
STAT- MEDLINE
DCOM- 20190304
LR  - 20190304
IS  - 1439-0507 (Electronic)
IS  - 0933-7407 (Linking)
VI  - 62
IP  - 2
DP  - 2019 Feb
TI  - DC-SIGN and VDR polymorphisms are associated with chronic form of 
      paracoccidioidomycosis with oral manifestations.
PG  - 186-192
LID - 10.1111/myc.12866 [doi]
AB  - Paracoccidioidomycosis (PCM) is a granulomatous disease caused by fungi of the 
      species complex of the Paracoccidioides genus. One of the main clinical 
      manifestations of PCM is the presence of oral lesions with the presence of 
      epithelioid granulomas. In this work, we aimed to evaluate the frequency of SNPs 
      in the TNF-alpha, JAK1, VDR, DC-SIGN and FcgammaRIIa genes in patients with chronic PCM 
      and verify possible association of these SNPs with the organisation pattern of 
      the granulomas in the oral lesions. A total of 66 samples of DNA were obtained 
      from oral lesions biopsies and 106 DNA samples were obtained from healthy 
      individuals. The individuals were genotyped for SNPs in DC-SIGN (rs4804803), 
      FcgammaRIIa (rs1801274), JAK1 (rs11208534), TNF-alpha (rs1800629) and VDR (rs7975232) by 
      real-time PCR and allele discrimination method. Granulomas were classified as 
      loose or dense according to the histological pattern. In the VDR (rs7975232), the 
      CC genotype (P < 0.001, OR = 5.94, 95% CI = 2.07-17.05), and the C allele 
      (P = 0.027, OR = 2.71, 95% CI = 1.07-6.86), as well as the GG genotype in DC-SIGN 
      (rs4804803) (P = 0.032, OR: 3.76, 95%, I = 1.06-13.38) are associated with an 
      increased risk of oral PCM. Our data indicate that VDR and DC-SIGN genetics 
      variations are related to the susceptibility of oral PCM in the group of patients 
      analysed.
CI  - (c) 2018 Blackwell Verlag GmbH.
FAU - Alves Pereira Neto, Tertuliano
AU  - Alves Pereira Neto T
AUID- ORCID: 0000-0001-9861-3275
AD  - Departamento de Microbiologia e Imunologia, Universidade Federal de Alfenas, 
      Alfenas, MG, Brazil.
FAU - Costa Pereira, Alessandro Antonio
AU  - Costa Pereira AA
AD  - Departamento de Patologia e Parasitologia, Universidade Federal de Alfenas, 
      Alfenas, MG, Brazil.
FAU - Costa Hanemann, Joao Adolfo
AU  - Costa Hanemann JA
AD  - Faculdade de Odontologia, Universidade Federal de Alfenas, Alfenas, MG, Brazil.
FAU - Coelho, Luiz Felipe Leomil
AU  - Coelho LFL
AD  - Departamento de Microbiologia e Imunologia, Universidade Federal de Alfenas, 
      Alfenas, MG, Brazil.
FAU - Malaquias, Luiz Cosme Cotta
AU  - Malaquias LCC
AD  - Departamento de Microbiologia e Imunologia, Universidade Federal de Alfenas, 
      Alfenas, MG, Brazil.
LA  - eng
GR  - 40400520128/CNPq/
PT  - Journal Article
DEP - 20181119
PL  - Germany
TA  - Mycoses
JT  - Mycoses
JID - 8805008
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (VDR protein, human)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Cell Adhesion Molecules/*genetics
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Granuloma/pathology
MH  - Histocytochemistry
MH  - Humans
MH  - Lectins, C-Type/*genetics
MH  - Male
MH  - Middle Aged
MH  - Mouth Diseases/*genetics/*pathology
MH  - Paracoccidioidomycosis/*genetics/*pathology
MH  - Polymorphism, Single Nucleotide
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, Calcitriol/*genetics
MH  - Receptors, Cell Surface/*genetics
OTO - NOTNLM
OT  - VDR
OT  - chronic paracoccidioidomycosis
OT  - DC-SIGN
OT  - single nucleotide polymorphism
EDAT- 2018/10/28 06:00
MHDA- 2019/03/05 06:00
CRDT- 2018/10/28 06:00
PHST- 2018/03/25 00:00 [received]
PHST- 2018/10/08 00:00 [revised]
PHST- 2018/10/21 00:00 [accepted]
PHST- 2018/10/28 06:00 [pubmed]
PHST- 2019/03/05 06:00 [medline]
PHST- 2018/10/28 06:00 [entrez]
AID - 10.1111/myc.12866 [doi]
PST - ppublish
SO  - Mycoses. 2019 Feb;62(2):186-192. doi: 10.1111/myc.12866. Epub 2018 Nov 19.