PMID- 30368878
OWN - NLM
STAT- MEDLINE
DCOM- 20200330
LR  - 20200330
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 90
IP  - 2
DP  - 2019 Feb
TI  - No evidence of adverse fertility and pregnancy outcomes in patients with 
      unrecognized and untreated multiple endocrine neoplasia type 1.
PG  - 312-319
LID - 10.1111/cen.13890 [doi]
AB  - OBJECTIVE: Literature concerning the impact of multiple endocrine neoplasia type 
      1 (MEN 1) on fertility is limited to case reports despite the early onset of 
      endocrinopathies, such as primary hyperparathyroidism and prolactinoma, that may 
      impact fertility. This study describes the impact of unrecognized and untreated 
      MEN 1 on fertility and pregnancy outcomes in a multigenerational cohort of the 
      Tasman 1 MEN 1 kindred. METHODS: All MEN 1 positive (MEN 1(+) , n = 63) and MEN 1 
      negative (MEN 1(-) , n = 75) descendants born between 1825 and 1951 of a common 
      founder. Review of birth, death, marriage and medical records provided data on 
      date of birth and death, gender, MEN 1 status and the number of pregnancies and 
      children per parent. RESULTS: Compared to MEN 1(-) parents, MEN 1(+) parents had 
      more children (RR 1.30, 1.02-1.66) and live births (RR 1.31, 1.02-1.67) with no 
      excess of stillbirths (RR 1.24, 0.24-6.36). Compared to the era-matched Tasmanian 
      fertility rate, MEN 1(+) parents had more children (4.87 +/- 4.11 vs 3.40 +/- 0.61, 
      P = 0.048), whereas MEN 1(-) parents had similar numbers of children (3.67 +/- 3.27 
      vs 3.36 +/- 0.62, P = 0.55). MEN 1(+) parents had a similar number of MEN 1(+) and 
      MEN 1(-) offspring (2.1 +/- 1.9 vs 2.5 +/- 2.3, P = 0.31). Indirectly assessed 
      miscarriage rate was similar between MEN 1(+) and MEN 1(-) mothers (P = 0.77). 
      Clinically overt pituitary disease reduced MEN 1(+) kindred member likelihood of 
      parenthood (33% vs 97%). CONCLUSIONS: There was no adverse impact of MEN 1 on 
      patient fertility overall; however, MEN 1-related pathology may have impaired the 
      reproductive potential of a subset of individuals with pituitary disease.
CI  - (c) 2018 John Wiley & Sons Ltd.
FAU - Thompson, Michael
AU  - Thompson M
AUID- ORCID: 0000-0003-1425-5808
AD  - School of Medicine, Department of Diabetes and Endocrinology, Royal Hobart 
      Hospital, University of Tasmania, Hobart, Tasmania.
FAU - Burgess, John
AU  - Burgess J
AD  - School of Medicine, Department of Diabetes and Endocrinology, Royal Hobart 
      Hospital, University of Tasmania, Hobart, Tasmania.
LA  - eng
PT  - Journal Article
DEP - 20181114
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
SB  - IM
MH  - Birth Rate
MH  - Female
MH  - *Fertility
MH  - Humans
MH  - Live Birth
MH  - Multiple Endocrine Neoplasia Type 1/*physiopathology
MH  - Pituitary Diseases
MH  - Pregnancy
MH  - *Pregnancy Outcome
MH  - Retrospective Studies
OTO - NOTNLM
OT  - fertility
OT  - multiple endocrine neoplasia type 1
OT  - pregnancy
EDAT- 2018/10/29 06:00
MHDA- 2020/03/31 06:00
CRDT- 2018/10/29 06:00
PHST- 2018/09/07 00:00 [received]
PHST- 2018/10/14 00:00 [revised]
PHST- 2018/10/22 00:00 [accepted]
PHST- 2018/10/29 06:00 [pubmed]
PHST- 2020/03/31 06:00 [medline]
PHST- 2018/10/29 06:00 [entrez]
AID - 10.1111/cen.13890 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2019 Feb;90(2):312-319. doi: 10.1111/cen.13890. Epub 2018 
      Nov 14.