PMID- 30368911 OWN - NLM STAT- MEDLINE DCOM- 20200709 LR - 20200709 IS - 1097-4644 (Electronic) IS - 0730-2312 (Linking) VI - 120 IP - 4 DP - 2019 Apr TI - Association of MCP-1 promoter polymorphism with susceptibility to nasopharyngeal carcinoma. PG - 6661-6670 LID - 10.1002/jcb.27962 [doi] AB - Nasopharyngeal carcinoma (NPC) is prevalent among populations from southern China and is influenced by both genetic and environmental risk factors. The monocyte chemoattractant protein-1 (MCP-1), a member of cysteine-cysteine chemokine family, plays critical roles in cancers. A polymorphism within the MCP-1 promoter, rs1024611, has been shown to be significantly associated with the risk of several cancers. Our purpose was to assess the role of rs1024611 in NPC susceptibility. By polymerase chain reaction-restriction fragment length polymorphism method, we genotyped rs1024611 in 593 patients with NPC (cases) and 480 cancer-free subjects (controls) among Guangxi population from southern China. We observed that the G allele of rs1024611 was significantly associated with the increased risk of NPC in an additive model and dominant model, respectively (P = 0.018 and 0.010, odds ratio = 1.25 and 1.41, respectively). No appreciable variation of the effects was found across the subgroups stratified by age, sex, nationality, smoking and drinking status, and smoking level. In addition, significantly higher messenger RNA (mRNA) expression level of MCP-1 was observed in NPC tissues than that in normal nasopharyngeal tissues, and the G allele of rs1024611 was significantly associated with elevated mRNA expression level of MCP-1 in Epstein-Barr virus-transformed lymphocytes. In conclusion, our findings suggested that rs1024611 at the MCP-1 promoter may be a risk factor for NPC. Further studies with larger sample size are necessary to confirm these findings. CI - (c) 2018 Wiley Periodicals, Inc. FAU - Niu, Yuguang AU - Niu Y AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. AD - ENT Department, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China. FAU - Zhou, Guangming AU - Zhou G AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. AD - Department of Genomics & Proteomics, National Engineering Research Center for Protein Drugs, Beijing, China. AD - Department of Genomics & Proteomics, National Center for Protein Sciences at Beijing, Beijing, China. FAU - Wang, Yahui AU - Wang Y AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. AD - Department of Genomics & Proteomics, National Engineering Research Center for Protein Drugs, Beijing, China. AD - Department of Genomics & Proteomics, National Center for Protein Sciences at Beijing, Beijing, China. AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China. FAU - Qin, Jianing AU - Qin J AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. FAU - Ping, Jie AU - Ping J AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. AD - Department of Genomics & Proteomics, National Engineering Research Center for Protein Drugs, Beijing, China. AD - Department of Genomics & Proteomics, National Center for Protein Sciences at Beijing, Beijing, China. FAU - Zhang, Qing AU - Zhang Q AD - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Han, Bo-Wei AU - Han BW AD - Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China. FAU - Liu, Yu-Xiang AU - Liu YX AD - Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China. FAU - Yang, Chenning AU - Yang C AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. AD - Department of Genomics & Proteomics, National Engineering Research Center for Protein Drugs, Beijing, China. AD - Department of Genomics & Proteomics, National Center for Protein Sciences at Beijing, Beijing, China. FAU - Zhai, Yun AU - Zhai Y AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. AD - Department of Genomics & Proteomics, National Engineering Research Center for Protein Drugs, Beijing, China. AD - Department of Genomics & Proteomics, National Center for Protein Sciences at Beijing, Beijing, China. FAU - Zhang, Hongxing AU - Zhang H AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. AD - Department of Genomics & Proteomics, National Engineering Research Center for Protein Drugs, Beijing, China. AD - Department of Genomics & Proteomics, National Center for Protein Sciences at Beijing, Beijing, China. FAU - He, Fuchu AU - He F AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. AD - Department of Genomics & Proteomics, National Engineering Research Center for Protein Drugs, Beijing, China. AD - Department of Genomics & Proteomics, National Center for Protein Sciences at Beijing, Beijing, China. AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China. FAU - Mai, Hai-Qiang AU - Mai HQ AD - Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China. FAU - Bei, Jin-Xin AU - Bei JX AD - Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China. FAU - Li, Yuanfeng AU - Li Y AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. AD - Department of Genomics & Proteomics, National Engineering Research Center for Protein Drugs, Beijing, China. AD - Department of Genomics & Proteomics, National Center for Protein Sciences at Beijing, Beijing, China. FAU - Zhou, Gangqiao AU - Zhou G AUID- ORCID: 0000-0002-4895-5063 AD - Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China. AD - Department of Genomics & Proteomics, National Engineering Research Center for Protein Drugs, Beijing, China. AD - Department of Genomics & Proteomics, National Center for Protein Sciences at Beijing, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20181028 PL - United States TA - J Cell Biochem JT - Journal of cellular biochemistry JID - 8205768 RN - 0 (Biomarkers, Tumor) RN - 0 (CCL2 protein, human) RN - 0 (Chemokine CCL2) SB - IM MH - Biomarkers, Tumor/genetics MH - Case-Control Studies MH - Chemokine CCL2/*genetics MH - *DNA Methylation MH - Female MH - Follow-Up Studies MH - *Gene Expression Regulation, Neoplastic MH - *Genetic Predisposition to Disease MH - Humans MH - Male MH - Middle Aged MH - Nasopharyngeal Carcinoma/genetics/*pathology MH - Nasopharyngeal Neoplasms/*genetics/pathology MH - *Polymorphism, Single Nucleotide MH - Prognosis MH - *Promoter Regions, Genetic OTO - NOTNLM OT - genetic susceptibility OT - monocyte chemoattractant protein-1 (MCP-1) OT - nasopharyngeal carcinoma (NPC) OT - single nucleotide polymorphisms (SNPs) EDAT- 2018/10/29 06:00 MHDA- 2020/07/10 06:00 CRDT- 2018/10/29 06:00 PHST- 2018/08/18 00:00 [received] PHST- 2018/10/02 00:00 [accepted] PHST- 2018/10/29 06:00 [pubmed] PHST- 2020/07/10 06:00 [medline] PHST- 2018/10/29 06:00 [entrez] AID - 10.1002/jcb.27962 [doi] PST - ppublish SO - J Cell Biochem. 2019 Apr;120(4):6661-6670. doi: 10.1002/jcb.27962. Epub 2018 Oct 28.