PMID- 30369272 OWN - NLM STAT- MEDLINE DCOM- 20191028 LR - 20191028 IS - 2167-9223 (Electronic) IS - 2167-8421 (Linking) VI - 19 IP - 7-8 DP - 2018 Nov TI - The Edinburgh Cognitive and Behavioral ALS screen: relationship to age, education, IQ and the Addenbrooke's Cognitive Examination-III. PG - 585-590 LID - 10.1080/21678421.2018.1491601 [doi] AB - The Edinburgh Cognitive and Behavioral ALS Screen (ECAS) was developed to assess cognitive and behavioral changes common in Amyotrophic Lateral Sclerosis and other diseases affecting motor functions. It focuses on domains typically affected by the frontotemporal syndrome (executive and language functions, fluency and behavior), but assesses also memory and visuospatial functions. OBJECTIVES: (A) To investigate the relationship between the ECAS and the Addenbrooke's Cognitive Examination (ACE-III). (B) To investigate the effects of age, education, and IQ on the ECAS and create appropriate cutoff scores to determine abnormality. METHODS: (A) 57 healthy participants (aged 35-80) were assessed with the ECAS, the Wechsler Abbreviated Scale of Intelligence (WASI-II), and the ACE-III. (B) 80 healthy participants (aged 51-80) were divided into four groups according to age and education; and were tested with the ECAS and the WASI-II. RESULTS: The ECAS and the ACE-III have a good convergent validity with a significant correlation. Regression analysis revealed that IQ, followed by age, were the strongest predictors of the total ECAS score. IQ predicted 24% of the ECAS and 46% of the ACE-III variance. Education was not a significant predictor over and above IQ for both the ECAS and the ACE-III. Abnormality cutoff scores adjusted for age and education are presented. CONCLUSIONS: The ECAS shows good convergent validity with the ACE-III, but is less influenced by intelligence and presents less ceiling effects. The inclusion of an executive function assessment and behavioral interview in the ECAS makes it particularly useful for the assessment of frontal lobe disorders. FAU - De Icaza Valenzuela, Monica M AU - De Icaza Valenzuela MM AD - a Human Cognitive Neuroscience - Department of Psychology , The University of Edinburgh , Edinburgh , UK. AD - b Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE) , The University of Edinburgh , Edinburgh , UK. AD - c Anne Rowling Regenerative Neurology Clinic , The University of Edinburgh , Edinburgh , UK. FAU - Bak, Thomas H AU - Bak TH AD - a Human Cognitive Neuroscience - Department of Psychology , The University of Edinburgh , Edinburgh , UK. AD - b Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE) , The University of Edinburgh , Edinburgh , UK. AD - c Anne Rowling Regenerative Neurology Clinic , The University of Edinburgh , Edinburgh , UK. AD - d Euan MacDonald Centre for Motor Neurone Disease Research , The University of Edinburgh , Edinburgh , UK , and. FAU - Pal, Suvankar AU - Pal S AD - c Anne Rowling Regenerative Neurology Clinic , The University of Edinburgh , Edinburgh , UK. AD - d Euan MacDonald Centre for Motor Neurone Disease Research , The University of Edinburgh , Edinburgh , UK , and. AD - e Centre for Clinical Brain Sciences , The University of Edinburgh , Edinburgh , UK. FAU - Abrahams, Sharon AU - Abrahams S AD - a Human Cognitive Neuroscience - Department of Psychology , The University of Edinburgh , Edinburgh , UK. AD - b Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE) , The University of Edinburgh , Edinburgh , UK. AD - c Anne Rowling Regenerative Neurology Clinic , The University of Edinburgh , Edinburgh , UK. AD - d Euan MacDonald Centre for Motor Neurone Disease Research , The University of Edinburgh , Edinburgh , UK , and. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20181029 PL - England TA - Amyotroph Lateral Scler Frontotemporal Degener JT - Amyotrophic lateral sclerosis & frontotemporal degeneration JID - 101587185 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - *Aging MH - Amyotrophic Lateral Sclerosis/*complications/*diagnosis MH - Cognition Disorders/*etiology MH - Educational Status MH - Female MH - Humans MH - Intelligence/*physiology MH - Male MH - Mental Disorders/*etiology MH - Middle Aged MH - Neuropsychological Tests OTO - NOTNLM OT - ECAS OT - IQ OT - age OT - behavior OT - cognition OT - education OT - frontotemporal dementia OT - screen EDAT- 2018/10/30 06:00 MHDA- 2019/10/29 06:00 CRDT- 2018/10/30 06:00 PHST- 2018/10/30 06:00 [pubmed] PHST- 2019/10/29 06:00 [medline] PHST- 2018/10/30 06:00 [entrez] AID - 10.1080/21678421.2018.1491601 [doi] PST - ppublish SO - Amyotroph Lateral Scler Frontotemporal Degener. 2018 Nov;19(7-8):585-590. doi: 10.1080/21678421.2018.1491601. Epub 2018 Oct 29.