PMID- 30371119
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20240403
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Print)
IS  - 0886-022X (Linking)
VI  - 40
IP  - 1
DP  - 2018 Nov
TI  - The association between the red cell distribution width and diabetic nephropathy 
      in patients with type-2 diabetes mellitus.
PG  - 590-596
LID - 10.1080/0886022X.2018.1532906 [doi]
AB  - BACKGROUND: Red cell distribution width (RDW) has been reported to be involved in 
      metabolic syndrome and cardiovascular events. Patients with diabetic nephropathy 
      (DN) are often found to be with high level of RDW. The aim of this study was to 
      explore whether RDW was associated with DN severity and progression in patients 
      with type-2 diabetes mellitus (T2DM). METHODS: A total of 175 T2DM patients with 
      biopsy-proven DN were enrolled. The baseline clinical and pathologic data of 
      these patients was extracted from the medical records. The patients then were 
      divided into two groups based on the median (13.6%) of RDW level; group 1: <13.6% 
      and group 2: >/=13.6%. The effect of RDW level on the renal outcomes was evaluated 
      by using cox regression analysis. RESULTS: Compared with the patients with lower 
      RDW level, the patients with higher level of RDW had higher proportions of 
      female, longer DM duration, lower levels of eGFR, albumin and hemoglobin, and 
      more serious glomerular damage. Moreover, the RDW levels were negatively 
      corrected with eGFR (r = -0.283, p < 0.001), but positively related with 
      proteinuria (r = 0.227, p = 0.003). In the follow-up period, 81(46.3%) patients 
      had reached ESRD from baseline. Importantly, the Cox regression analyses showed 
      that the levels of RDM had a significant effect on the risk of progression to 
      ESRD (HR = 1.92, p < 0.01), albeit not emerged as an independent predictor. 
      CONCLUSIONS: These data indicated that the levels of RDW were significantly 
      associated with increased risk of progression to ESRD in patients with DN, 
      despite did not an independent predictor.
FAU - Zhang, Junlin
AU  - Zhang J
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Wang, Yiting
AU  - Wang Y
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Li, Hanyu
AU  - Li H
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Han, Qianqian
AU  - Han Q
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Wu, Yucheng
AU  - Wu Y
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Wang, Shanshan
AU  - Wang S
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Guo, Ruikun
AU  - Guo R
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Wang, Tingli
AU  - Wang T
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Li, Li
AU  - Li L
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Liu, Fang
AU  - Liu F
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
SB  - IM
MH  - China
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Nephropathies/*blood/pathology/*physiopathology
MH  - Disease Progression
MH  - *Erythrocyte Indices
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Kidney Failure, Chronic/*complications
MH  - Kidney Glomerulus/pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - Severity of Illness Index
PMC - PMC6211258
OTO - NOTNLM
OT  - diabetic nephropathy
OT  - end-stage renal disease
OT  - red cell distribution width
OT  - type-2 diabetes mellitus
EDAT- 2018/10/30 06:00
MHDA- 2018/12/12 06:00
PMCR- 2018/10/29
CRDT- 2018/10/30 06:00
PHST- 2018/10/30 06:00 [entrez]
PHST- 2018/10/30 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/10/29 00:00 [pmc-release]
AID - 1532906 [pii]
AID - 10.1080/0886022X.2018.1532906 [doi]
PST - ppublish
SO  - Ren Fail. 2018 Nov;40(1):590-596. doi: 10.1080/0886022X.2018.1532906.