PMID- 30371170
OWN - NLM
STAT- MEDLINE
DCOM- 20191121
LR  - 20231004
IS  - 2047-9980 (Electronic)
IS  - 2047-9980 (Linking)
VI  - 7
IP  - 17
DP  - 2018 Sep 4
TI  - Micronutrient Deficiency Independently Predicts Time to Event in Patients With 
      Heart Failure.
PG  - e007251
LID - 10.1161/JAHA.117.007251 [doi]
LID - e007251
AB  - Background Dietary micronutrient deficiencies have been shown to predict 
      event-free survival in other countries but have not been examined in patients 
      with heart failure living in the United States. The purpose of this study was to 
      determine whether number of dietary micronutrient deficiencies in patients with 
      heart failure was associated with shorter event-free survival, defined as a 
      combined end point of all-cause hospitalization and death. Methods and Results 
      Four-day food diaries were collected from 246 patients with heart failure (age: 
      61.5+/-12 years; 67% male; 73% white; 45% New York Heart Association [NYHA] class 
      III / IV ) and analyzed using Nutrition Data Systems for Research. Micronutrient 
      deficiencies were determined according to methods recommended by the Institute of 
      Medicine. Patients were followed for 1 year to collect data on all-cause 
      hospitalization or death. Patients were divided according to number of dietary 
      micronutrient deficiencies at a cut point of >/=7 for the high deficiency category 
      versus <7 for the no to moderate deficiency category. In the full sample, 29.8% 
      of patients experienced hospitalization or death during the year, including 44.3% 
      in the high-deficiency group and 25.1% in the no/moderate group. The difference 
      in survival distribution was significant (log rank, P=0.0065). In a Cox 
      regression, micronutrient deficiency category predicted time to event with 
      depression, NYHA classification, comorbidity burden, body mass index, calorie and 
      sodium intake, and prescribed angiotensin-converting enzyme inhibitors, 
      diuretics, or beta-blockers included as covariates. Conclusions This study provides 
      additional convincing evidence that diet quality of patients with heart failure 
      plays an important role in heart failure outcomes.
FAU - Lennie, Terry A
AU  - Lennie TA
AD  - 1 College of Nursing University of Kentucky Lexington KY.
FAU - Andreae, Christina
AU  - Andreae C
AD  - 2 Division of Nursing Science Department of Medical and Health Sciences Linkoping 
      University Linkoping Sweden.
FAU - Rayens, Mary Kay
AU  - Rayens MK
AD  - 1 College of Nursing University of Kentucky Lexington KY.
FAU - Song, Eun Kyeung
AU  - Song EK
AD  - 3 Department of Nursing College of Medicine University of Ulsan Korea.
FAU - Dunbar, Sandra B
AU  - Dunbar SB
AD  - 4 Emory University Atlanta GA.
FAU - Pressler, Susan J
AU  - Pressler SJ
AD  - 5 Indiana University Indianapolis IN.
FAU - Heo, Seongkum
AU  - Heo S
AD  - 6 College of Nursing University of Arkansas for Medical Sciences Little Rock AR.
FAU - Kim, JinShil
AU  - Kim J
AD  - 7 Gachon University College of Nursing Incheon Korea.
FAU - Moser, Debra K
AU  - Moser DK
AD  - 1 College of Nursing University of Kentucky Lexington KY.
LA  - eng
GR  - M01 RR000750/RR/NCRR NIH HHS/United States
GR  - UL1 TR000117/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - J Am Heart Assoc
JT  - Journal of the American Heart Association
JID - 101580524
RN  - 0 (Micronutrients)
SB  - IM
CIN - J Am Heart Assoc. 2018 Sep 4;7(17):e010447. PMID: 30371174
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Heart Failure/*epidemiology
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Malnutrition/*epidemiology
MH  - Micronutrients/*deficiency
MH  - Middle Aged
MH  - Mortality
MH  - Progression-Free Survival
MH  - Proportional Hazards Models
MH  - Time Factors
MH  - United States/epidemiology
MH  - Young Adult
PMC - PMC6201427
OTO - NOTNLM
OT  - diet
OT  - heart failure
OT  - nutrition
OT  - risk factor
OT  - survival analysis
EDAT- 2018/10/30 06:00
MHDA- 2019/11/22 06:00
PMCR- 2018/09/04
CRDT- 2018/10/30 06:00
PHST- 2018/10/30 06:00 [entrez]
PHST- 2018/10/30 06:00 [pubmed]
PHST- 2019/11/22 06:00 [medline]
PHST- 2018/09/04 00:00 [pmc-release]
AID - JAH33424 [pii]
AID - 10.1161/JAHA.117.007251 [doi]
PST - ppublish
SO  - J Am Heart Assoc. 2018 Sep 4;7(17):e007251. doi: 10.1161/JAHA.117.007251.