PMID- 30372851
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 108
DP  - 2018 Dec
TI  - Evaluation of antidiabetic activity of bud and flower of Avaram Senna (Cassia 
      auriculata L.) In high fat diet and streptozotocin induced diabetic rats.
PG  - 1495-1506
LID - S0753-3322(18)34585-2 [pii]
LID - 10.1016/j.biopha.2018.10.007 [doi]
AB  - Type 2 Diabetes Mellitus (T2DM) is very common metabolic disorder affecting 
      people of all age groups. The change in life style and environmental factors are 
      the considerable factors which are involved in the development of the disorder. 
      The different parts of medicinal plants vary in their composition of bioactive 
      compounds. There are reports on antidiabetic activity of C. auriculata L. flower 
      and leaves. Traditionally bud of C. auriculata L. is used to treat diabetes 
      rather than flower. This study aims to explore the antidiabetic efficiency of bud 
      and flower and to identify the differential composition of phycompounds present 
      in bud and flower parts of C. auriculata L. The compounds present in the bud and 
      flower parts were identified using LC-ESI/MS analysis. Antidiabetic activity of 
      C. auriculata L. bud and flower parts was studied in high fat diet (HFD) and 
      streptozotocin (STZ) induced diabetic rats. During which parameters such as feed 
      intake, water intake, and body weight were monitored. After 21 days of the study, 
      blood parameters like insulin, glucose, lipid profile, hepatic function test, 
      renal function test and oxidative stress markers were analysed. Real time PCR was 
      done to monitor the expression of IRS2 and GRIA2 genes. The LC-ESI/MS analysis 
      showed the presence of various phenolics and flavonoid compounds specific to bud 
      and flower parts. The antidiabetic activity results showed that the animal 
      treated with C. auriculata L. bud ethanol extract (CABE500) could better reverse 
      and control the progression of the disease compared to the flower ethanol 
      extract. The gene expression studies revealed that regulation of IRS2 gene 
      occurred in bud but not in flower extract treated animal livers and no 
      differential expression of GRIA2 gene in all the experimental groups. C. 
      auriculata L. bud extract can potentially better control the diabetes compared to 
      the flower extract.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Nambirajan, Gayathri
AU  - Nambirajan G
AD  - Department of Environmental Biotechnology, Bharathidasan University, 
      Tiruchirappalli 620 024, Tamil Nadu, India.
FAU - Karunanidhi, Kaleshkumar
AU  - Karunanidhi K
AD  - Department of Marine Science, Bharathidasan University, Tiruchirappalli 620 024, 
      Tamil Nadu, India.
FAU - Ganesan, Arun
AU  - Ganesan A
AD  - Department of Marine Science, Bharathidasan University, Tiruchirappalli 620 024, 
      Tamil Nadu, India.
FAU - Rajendran, Rajaram
AU  - Rajendran R
AD  - Department of Marine Science, Bharathidasan University, Tiruchirappalli 620 024, 
      Tamil Nadu, India.
FAU - Kandasamy, Ruckmani
AU  - Kandasamy R
AD  - National Facility for Drug Development for Academia, Pharmaceutical and Allied 
      Industries (NFDD), Centre for Excellence in Nanobio Translational REsearch 
      (CENTRE), Department of Pharmaceutical Technology, University College of 
      Engineering, Anna University, BIT Campus, Tiruchirappalli 620 024, Tamil Nadu, 
      India.
FAU - Elangovan, Abbirami
AU  - Elangovan A
AD  - Department of Environmental Biotechnology, Bharathidasan University, 
      Tiruchirappalli 620 024, Tamil Nadu, India.
FAU - Thilagar, Sivasudha
AU  - Thilagar S
AD  - Department of Environmental Biotechnology, Bharathidasan University, 
      Tiruchirappalli 620 024, Tamil Nadu, India. Electronic address: 
      sudacoli@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20181009
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Plant Extracts)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Animals
MH  - Blood Glucose/drug effects/metabolism
MH  - *Cassia
MH  - Diabetes Mellitus, Experimental/blood/*drug therapy/etiology
MH  - Diet, High-Fat/*adverse effects
MH  - Drug Evaluation, Preclinical/methods
MH  - *Flowers
MH  - Hypoglycemic Agents/isolation & purification/pharmacology/*therapeutic use
MH  - Male
MH  - Plant Extracts/isolation & purification/pharmacology/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Streptozocin/toxicity
OTO - NOTNLM
OT  - Antioxidants
OT  - Diabetes mellitus
OT  - IRS2 gene
OT  - Streptozotocin
OT  - alpha Amylase
OT  - alpha Glucosidase
EDAT- 2018/10/31 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/10/31 06:00
PHST- 2018/07/04 00:00 [received]
PHST- 2018/10/01 00:00 [revised]
PHST- 2018/10/02 00:00 [accepted]
PHST- 2018/10/31 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/10/31 06:00 [entrez]
AID - S0753-3322(18)34585-2 [pii]
AID - 10.1016/j.biopha.2018.10.007 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Dec;108:1495-1506. doi: 10.1016/j.biopha.2018.10.007. 
      Epub 2018 Oct 9.