PMID- 30373107
OWN - NLM
STAT- MEDLINE
DCOM- 20190205
LR  - 20190215
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 11
DP  - 2018 Oct 26
TI  - SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric 
      Restriction.
LID - 10.3390/ijms19113335 [doi]
LID - 3335
AB  - Caloric restriction (CR) delays the onset of many age-related pathophysiological 
      changes and extends lifespan. White adipose tissue (WAT) is not only a major 
      tissue for energy storage, but also an endocrine tissue that secretes various 
      adipokines. Recent reports have demonstrated that alterations in the 
      characteristics of WAT can impact whole-body metabolism and lifespan. Hence, we 
      hypothesized that functional alterations in WAT may play important roles in the 
      beneficial effects of CR. Previously, using microarray analysis of WAT from CR 
      rats, we found that CR enhances fatty acid (FA) biosynthesis, and identified 
      sterol regulatory element-binding protein 1c (SREBP-1c), a master regulator of FA 
      synthesis, as a mediator of CR. These findings were validated by showing that CR 
      failed to upregulate factors involved in FA biosynthesis and to extend longevity 
      in SREBP-1c knockout mice. Furthermore, we revealed that SREBP-1c is implicated 
      in CR-associated mitochondrial activation through the upregulation of peroxisome 
      proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha), a master regulator of 
      mitochondrial biogenesis. Notably, these CR-associated phenotypes were observed 
      only in WAT. We conclude that CR induces SREBP-1c-dependent metabolic remodeling, 
      including the enhancement of FA biosynthesis and mitochondrial activation, via 
      PGC-1alpha in WAT, resulting in beneficial effects.
FAU - Kobayashi, Masaki
AU  - Kobayashi M
AUID- ORCID: 0000-0002-0985-0322
AD  - Laboratory of Molecular Pathology and Metabolic Disease, Faculty of 
      Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 
      278-8510, Japan. kobayashim@rs.tus.ac.jp.
AD  - Translational Research Center, Research Institute of Science and Technology, 
      Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. 
      kobayashim@rs.tus.ac.jp.
FAU - Fujii, Namiki
AU  - Fujii N
AD  - Laboratory of Molecular Pathology and Metabolic Disease, Faculty of 
      Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 
      278-8510, Japan. 3b16710@ed.tus.ac.jp.
FAU - Narita, Takumi
AU  - Narita T
AD  - Epidemiology and Prevention Division, Research Center for Cancer Prevention and 
      Screening, National Cancer Center, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. 
      tanarita@ncc.go.jp.
FAU - Higami, Yoshikazu
AU  - Higami Y
AD  - Laboratory of Molecular Pathology and Metabolic Disease, Faculty of 
      Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 
      278-8510, Japan. higami@rs.noda.tus.ac.jp.
AD  - Translational Research Center, Research Institute of Science and Technology, 
      Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. 
      higami@rs.noda.tus.ac.jp.
LA  - eng
GR  - 17K13231/Grants-in-Aid for Young Scientists (B)/
GR  - 17H02179/Grants-in-Aid for Scientific Research (B)/
GR  - 2014-2018/MEXT Supported Program for the Strategic Research Foundation at Private 
      Universities/
PT  - Journal Article
PT  - Review
DEP - 20181026
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Fatty Acids)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Sterol Regulatory Element Binding Protein 1)
SB  - IM
MH  - Adipose Tissue, White/*metabolism
MH  - Animals
MH  - *Caloric Restriction/methods
MH  - Fatty Acids/metabolism
MH  - Humans
MH  - Lipogenesis
MH  - Longevity
MH  - Mitochondria/metabolism
MH  - Organelle Biogenesis
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
MH  - Sterol Regulatory Element Binding Protein 1/*metabolism
PMC - PMC6275055
OTO - NOTNLM
OT  - PGC-1alpha
OT  - SREBP-1c
OT  - caloric restriction
OT  - fatty acid synthesis
OT  - mitochondrion
OT  - white adipose tissue
COIS- The authors declare no conflict of interest.
EDAT- 2018/10/31 06:00
MHDA- 2019/02/06 06:00
PMCR- 2018/11/01
CRDT- 2018/10/31 06:00
PHST- 2018/08/31 00:00 [received]
PHST- 2018/10/21 00:00 [revised]
PHST- 2018/10/21 00:00 [accepted]
PHST- 2018/10/31 06:00 [entrez]
PHST- 2018/10/31 06:00 [pubmed]
PHST- 2019/02/06 06:00 [medline]
PHST- 2018/11/01 00:00 [pmc-release]
AID - ijms19113335 [pii]
AID - ijms-19-03335 [pii]
AID - 10.3390/ijms19113335 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Oct 26;19(11):3335. doi: 10.3390/ijms19113335.