PMID- 30374005
OWN - NLM
STAT- MEDLINE
DCOM- 20190621
LR  - 20190621
IS  - 0917-5857 (Print)
IS  - 0917-5857 (Linking)
VI  - 28
IP  - 11
DP  - 2018
TI  - [Bone and calcium metabolism associated with malignancy. Treatment of radium-223 
      dichloride for bone metastasis in castration resistant prostate cancer 
      patients.].
PG  - 1485-1493
AB  - In patients with castration resistant prostate cancer(CRPC), the most frequent 
      site of metastases is bone particularly with osteoblastic change, which accounts 
      for 90% at the late stage of CRPC and is accompanied by symptomatic skeletal 
      symptoms(SSEs)such as bone pain or pathological fractures. 
      Radium-223(Ra-223)dichloride emits alpha particles and has been proven to improve 
      overall survival(OS)and QOL by reducing SSEs in metastatic CRPC patients. 
      Although hemotoxic adverse events(AEs)of Ra-223 treatment including anemia, 
      neutropenia and thrombocytopenia, and non-hemotoxic AEs including nausea, 
      diarrhea and bone pain have been reported, they were mild and well tolerated. The 
      completion of 6 injections of Ra-223 is important for prolonging OS. The optimal 
      time of Ra-223 administration is recommended the duration when PSA is increasing 
      regardless of abiraterone or enzalutamide treatment prior to chemotherapy.
FAU - Uemura, Hiroji
AU  - Uemura H
AD  - Department of Urology and Renal Transplantation, Yokohama City University Medical 
      Center, Japan.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Clin Calcium
JT  - Clinical calcium
JID - 9433326
RN  - 8BR2SOL3L1 (Radium-223)
RN  - SY7Q814VUP (Calcium)
RN  - W90AYD6R3Q (Radium)
SB  - IM
MH  - Bone Neoplasms/*radiotherapy/*secondary
MH  - Calcium
MH  - Humans
MH  - Male
MH  - Prostatic Neoplasms, Castration-Resistant/*secondary
MH  - Radium/*therapeutic use
EDAT- 2018/10/31 06:00
MHDA- 2019/06/22 06:00
CRDT- 2018/10/31 06:00
PHST- 2018/10/31 06:00 [entrez]
PHST- 2018/10/31 06:00 [pubmed]
PHST- 2019/06/22 06:00 [medline]
AID - 181114851493 [pii]
PST - ppublish
SO  - Clin Calcium. 2018;28(11):1485-1493.