PMID- 30374313
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 9
DP  - 2018
TI  - Coronary Microvascular Remodeling in Type 2 Diabetes: Synonymous With Early 
      Aging?
PG  - 1463
LID - 10.3389/fphys.2018.01463 [doi]
LID - 1463
AB  - Type 2 diabetes mellitus (T2DM) is suggested to cause an "early vascular aging" 
      phenomenon that is associated with vascular dysfunction, remodeling, and adverse 
      alterations in vascular stiffness. Given that both T2DM and aging are prominent 
      risk factors for cardiovascular disease, the aim of this study was to test the 
      hypothesis that coronary resistance microvessel (CRM) remodeling and impairments 
      in flow occur in the compound setting of T2DM and aging. Normal heterozygous 
      Db/db controls and homozygous db/db mice were aged to 16 (young) or 36 (aged) 
      weeks for all experiments and passive pressure myography and echocardiography 
      were used to assess vascular mechanics, and structure. CRM wall thickness was 
      significantly increased at each pressure in aged control mice compared to young 
      control mice (9.4 +/- 0.6 vs. 6.8 +/- 0.2 mum, respectively, p < 0.001); however, 
      there were no significant differences in CRM wall thickness of aged db/db mice 
      vs. young db/db mice. Aged control mice had a higher medial CSA compared to young 
      control mice (3847 +/- 303 vs. 2715 +/- 170 mum(2), p < 0.01); however, there were no 
      significant differences in medial CSA of aged db/db mice vs. young db/db mice. 
      Elastic modulus was lower in aged control CRMs vs. young control CRMs (3.5x10(6)+/- 
      0.7 x 10(6) vs. 8.7 x 10(6)+/- 0.6 x 10(6), p < 0.0001). Elastic modulus remained 
      the same in young db/db mice vs. aged db/db mice. These data show that the 
      diabetic CRMs undergo adverse remodeling at an early age, similar to normal aged 
      CRMs, that persists toward senescence, and it further suggests that diabetic CRMs 
      are subject to an early aging phenomenon.
FAU - McCallinhart, Patricia E
AU  - McCallinhart PE
AD  - Center for Cardiovascular Research, The Research Institute at Nationwide 
      Children's Hospital, Columbus, OH, United States.
AD  - The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States.
FAU - Sunyecz, Ian L
AU  - Sunyecz IL
AD  - Center for Cardiovascular Research, The Research Institute at Nationwide 
      Children's Hospital, Columbus, OH, United States.
AD  - The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States.
FAU - Trask, Aaron J
AU  - Trask AJ
AD  - Center for Cardiovascular Research, The Research Institute at Nationwide 
      Children's Hospital, Columbus, OH, United States.
AD  - The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States.
AD  - Department of Pediatrics, The Ohio State University College of Medicine, 
      Columbus, OH, United States.
LA  - eng
GR  - R00 HL116769/HL/NHLBI NIH HHS/United States
GR  - S10 OD023438/OD/NIH HHS/United States
PT  - Journal Article
DEP - 20181015
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6196247
OTO - NOTNLM
OT  - aging
OT  - coronary remodeling
OT  - microcirculation
OT  - type 2 diabetes
OT  - vascular remodeling
OT  - vascular stiffness
EDAT- 2018/10/31 06:00
MHDA- 2018/10/31 06:01
PMCR- 2018/10/15
CRDT- 2018/10/31 06:00
PHST- 2018/05/23 00:00 [received]
PHST- 2018/09/27 00:00 [accepted]
PHST- 2018/10/31 06:00 [entrez]
PHST- 2018/10/31 06:00 [pubmed]
PHST- 2018/10/31 06:01 [medline]
PHST- 2018/10/15 00:00 [pmc-release]
AID - 10.3389/fphys.2018.01463 [doi]
PST - epublish
SO  - Front Physiol. 2018 Oct 15;9:1463. doi: 10.3389/fphys.2018.01463. eCollection 
      2018.