PMID- 30374328
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 9
DP  - 2018
TI  - Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 
      Diabetic Rats: Activation of Akt/GSK-3beta and Inhibition of IRE1alpha-XBP1 Pathways.
PG  - 586
LID - 10.3389/fendo.2018.00586 [doi]
LID - 586
AB  - Type 2 diabetes mellitus (T2DM) is the most common type of diabetes with more 
      than hundreds of millions of patients worldwide. However, the medicines for 
      treatment of T2DM are very limited. In China, Punica granatum L. flower (PGF) has 
      been used as an anti-diabetic herb in the herbal medicine. The activity involves 
      in improvement of insulin sensitivity. However, the underlying mechanism of 
      action is elusive. The current study was designed to address this issue by 
      investigating the effect of polyphenols extract of PGF in diabetic rats. A rat 
      model was orally administrated with PGF polyphenols extract at doses of 50 and 
      100 mg/kg for 4 weeks. Insulin sensitivity was improved as indicated by oral 
      glucose tolerance test (OGTT), insulin tolerance test (ITT) and homeostasis model 
      assessment of insulin resistance (HOMA-IR). At the molecular level, insulin 
      signaling activity was improved with an elevation in insulin-stimulated 
      phosphorylation of insulin receptor substrate (IRS-1), Akt and GSK-3beta. 
      Endoplasmic reticulum (ER) stress signals including phosphorylation of 
      inositol-requiring kinase1 (IRE1) and activation of X box binding protein (XBP-1) 
      splicing were decreased by the PGF treatment. Expressions of IRE1alpha, XBPs, and 
      CHOP were all decreased by PGF. Blood lipid profile, liver glycogen content and 
      antioxidant status were improved by PGF in the rats. The observations suggest 
      that PGF is able to lower glucose levels in T2DM rats by improving the insulin 
      resistance. The mechanism is likely related to the activation of Akt-GSK3beta 
      signaling pathway and inhibition of ER stress.
FAU - Tang, Dan
AU  - Tang D
AD  - State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource 
      Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Urumqi, China.
FAU - Liu, Liu
AU  - Liu L
AD  - State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource 
      Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Urumqi, China.
AD  - University of Chinese Academy of Sciences, Beijing, China.
FAU - Ajiakber, Dildar
AU  - Ajiakber D
AD  - University of Chinese Academy of Sciences, Beijing, China.
AD  - Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 
      China.
FAU - Ye, Jianping
AU  - Ye J
AD  - Pennington Biomedical Research Center, Louisisana State University, Baton Rouge, 
      LA, United States.
FAU - Xu, Jianjun
AU  - Xu J
AD  - State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource 
      Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Urumqi, China.
AD  - University of Chinese Academy of Sciences, Beijing, China.
FAU - Xin, Xuelei
AU  - Xin X
AD  - State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource 
      Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Urumqi, China.
FAU - Aisa, Haji Akber
AU  - Aisa HA
AD  - State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource 
      Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Urumqi, China.
LA  - eng
PT  - Journal Article
DEP - 20181015
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6196233
OTO - NOTNLM
OT  - Punica granatum L. flower
OT  - anti-diabetic herb
OT  - endoplasmic reticulum stress
OT  - insulin resistance
OT  - oral glucose tolerance test
OT  - type 2 diabetes mellitus
EDAT- 2018/10/31 06:00
MHDA- 2018/10/31 06:01
PMCR- 2018/01/01
CRDT- 2018/10/31 06:00
PHST- 2018/06/20 00:00 [received]
PHST- 2018/09/17 00:00 [accepted]
PHST- 2018/10/31 06:00 [entrez]
PHST- 2018/10/31 06:00 [pubmed]
PHST- 2018/10/31 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2018.00586 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2018 Oct 15;9:586. doi: 10.3389/fendo.2018.00586. 
      eCollection 2018.