PMID- 30374679
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20200518
IS  - 1432-0738 (Electronic)
IS  - 0340-5761 (Linking)
VI  - 93
IP  - 2
DP  - 2019 Feb
TI  - Acrylamide aggravates cognitive deficits at night period via the gut-brain axis 
      by reprogramming the brain circadian clock.
PG  - 467-486
LID - 10.1007/s00204-018-2340-7 [doi]
AB  - Imbalance of the circadian rhythm leads to pathologies including obesity, 
      neurodegenerative diseases, and even cancer. Acrylamide (ACR) is a chronic 
      neurotoxin which can lead to carcinogenicity, reproduction toxicity, 
      teratogenicity, and neurotoxicity. The aim of this study was to reveal a 
      potential mechanism of ACR-triggered neurotoxicity related to circadian clock in 
      mice brain. For this purpose, 80 3-month-old C57/BL6J mice were randomly divided 
      into two groups (n = 40/group): the control group was fed a standard diet 
      (AIN-93M) with pure water, and the ACR group was fed a standard diet (AIN-93M) 
      with 0.003% ACR in drinking water for 16 weeks. In the current study, ACR 
      treatment induced circadian disorder and suppressed the circadian-related protein 
      expressions in mice brain. Furthermore, ACR diet aggravated the cognitive 
      dysfunction and spatial memory loss at night phase. Consistent with these 
      results, ACR caused cognitive defects in the night period by down-regulating the 
      ERK/cAMP response element-binding protein (CREB)/brain-derived neurotrophic 
      factor (BDNF) signaling pathways and the expression of synaptosomal-related 
      protein SNAP-25 and PSD-95. Moreover, excessive autophagy phenomenon also 
      occurred in mice hippocampus in the night phase under ACR administration. Of 
      note, ACR stimulated the brain inflammatory reaction via affecting the intestinal 
      barrier integrity and increasing the levels of circulating LPS, IL-1beta and TNF-alpha. 
      Above all, the present research discovered that ACR is a potential 
      circadian-depressing compound that influences cognitive function in mice brain.
FAU - Tan, Xintong
AU  - Tan X
AD  - Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science 
      and Engineering, Northwest A&F University, Xinong Road 2, 712100, Yangling, 
      China.
FAU - Ye, Jin
AU  - Ye J
AD  - Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science 
      and Engineering, Northwest A&F University, Xinong Road 2, 712100, Yangling, 
      China.
FAU - Liu, Weiqi
AU  - Liu W
AD  - Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science 
      and Engineering, Northwest A&F University, Xinong Road 2, 712100, Yangling, 
      China.
FAU - Zhao, Beita
AU  - Zhao B
AD  - Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science 
      and Engineering, Northwest A&F University, Xinong Road 2, 712100, Yangling, 
      China.
FAU - Shi, Xu
AU  - Shi X
AD  - Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science 
      and Engineering, Northwest A&F University, Xinong Road 2, 712100, Yangling, 
      China.
FAU - Zhang, Chengliang
AU  - Zhang C
AD  - Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science 
      and Engineering, Northwest A&F University, Xinong Road 2, 712100, Yangling, 
      China.
FAU - Liu, Zhigang
AU  - Liu Z
AD  - Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science 
      and Engineering, Northwest A&F University, Xinong Road 2, 712100, Yangling, 
      China.
FAU - Liu, Xuebo
AU  - Liu X
AD  - Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science 
      and Engineering, Northwest A&F University, Xinong Road 2, 712100, Yangling, 
      China. xueboliu@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181029
PL  - Germany
TA  - Arch Toxicol
JT  - Archives of toxicology
JID - 0417615
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotoxins)
RN  - 20R035KLCI (Acrylamide)
SB  - IM
MH  - Acrylamide/*toxicity
MH  - Animals
MH  - Autophagy/drug effects
MH  - Brain/*drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Circadian Clocks/*drug effects/physiology
MH  - Cognition Disorders/*chemically induced
MH  - Gastroenteritis/chemically induced/pathology
MH  - Gastrointestinal Tract/*drug effects/metabolism
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/drug effects/pathology
MH  - Maillard Reaction
MH  - Memory Disorders/chemically induced
MH  - Memory, Short-Term/drug effects
MH  - Mice, Inbred C57BL
MH  - Neurotoxins/toxicity
MH  - Organ Size/drug effects
MH  - Synapses/drug effects/pathology
OTO - NOTNLM
OT  - Acrylamide
OT  - Circadian rhythm
OT  - Cognitive impairment
OT  - Gut-brain axis
OT  - Synaptic plasticity
EDAT- 2018/10/31 06:00
MHDA- 2020/05/19 06:00
CRDT- 2018/10/31 06:00
PHST- 2018/07/25 00:00 [received]
PHST- 2018/10/23 00:00 [accepted]
PHST- 2018/10/31 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2018/10/31 06:00 [entrez]
AID - 10.1007/s00204-018-2340-7 [pii]
AID - 10.1007/s00204-018-2340-7 [doi]
PST - ppublish
SO  - Arch Toxicol. 2019 Feb;93(2):467-486. doi: 10.1007/s00204-018-2340-7. Epub 2018 
      Oct 29.