PMID- 30375090 OWN - NLM STAT- MEDLINE DCOM- 20200312 LR - 20200312 IS - 1540-8167 (Electronic) IS - 1045-3873 (Print) IS - 1045-3873 (Linking) VI - 30 IP - 2 DP - 2019 Feb TI - Characterization of edema after cryo and radiofrequency ablations based on serial magnetic resonance imaging. PG - 255-262 LID - 10.1111/jce.13785 [doi] AB - INTRODUCTION: Radiofrequency (RF) and cryoablation are routinely used to treat arrhythmias, but the extent and time course of edema associated with the two different modalities is unknown. Our goal was to follow the lesion maturation and edema formation after RF and cryoablation using serial magnetic resonance imaging (MRI). METHODS AND RESULTS: Ventricular ablation was performed in a canine model (n = 11) using a cryo or an irrigated RF catheter. T2-weighted (T2w) edema imaging and late gadolinium enhancement (LGE)-MRI were done immediately (0 day: acute), 1 to 2 weeks (subacute), and 8 to 12 weeks (chronic) after ablation. After the final MRI, excised hearts underwent pathological evaluation. As a result, 45 ventricular lesions (cryo group: 20; RF group: 25) were evaluated. Acute LGE volume was not significantly different but acute edema volume in cryo group was significantly smaller (1225.0 +/- 263.5 vs 1855.2 +/- 520.5 mm(3) ; P = 0.01). One week after ablation, edema still existed in both group but was similar in size. Two weeks after ablation there was no edema in either of the groups. In the chronic phase, the lesion volume for cryo and RF in LGE-MRI (296.7 +/- 156.4 vs 281.6 +/- 140.8 mm(3) ; P = 0.73); and pathology (243.3 +/- 125.9 vs 214.5 +/- 148.6 mm(3) ; P = 0.49), as well as depth, was comparable. CONCLUSIONS: When comparing cryo and RF lesions of similar chronic size, acute edema is larger for RF lesions. Edema resolves in both cryo and RF lesions in 1 to 2 weeks. CI - (c) 2018 Wiley Periodicals, Inc. FAU - Yamashita, Kennosuke AU - Yamashita K AUID- ORCID: 0000-0002-5630-1975 AD - Department of Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah. AD - Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah. FAU - Kholmovski, Eugene AU - Kholmovski E AUID- ORCID: 0000-0002-3271-7247 AD - Department of Radiology and Imaging Sciences, UCAIR, University of Utah, Salt Lake City, Utah. AD - CARMA Center, Department of Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah. FAU - Ghafoori, Elyar AU - Ghafoori E AD - Department of Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah. AD - Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah. AD - Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah. FAU - Kamali, Roya AU - Kamali R AD - Department of Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah. AD - Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah. AD - Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah. FAU - Kwan, Eugene AU - Kwan E AD - Department of Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah. AD - Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah. AD - Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah. FAU - Lichter, Justin AU - Lichter J AD - Department of Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah. AD - Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah. FAU - MacLeod, Robert AU - MacLeod R AD - Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah. AD - Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah. FAU - Dosdall, Derek J AU - Dosdall DJ AD - Department of Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah. AD - Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah. AD - Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah. AD - Department of Surgery, Division of Cardiothoracic Surgery, University of Utah, Salt Lake City, Utah. FAU - Ranjan, Ravi AU - Ranjan R AUID- ORCID: 0000-0002-3321-2435 AD - Department of Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah. AD - Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah. AD - Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah. LA - eng GR - K23 HL115084/HL/NHLBI NIH HHS/United States GR - P41 GM103545/GM/NIGMS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20181121 PL - United States TA - J Cardiovasc Electrophysiol JT - Journal of cardiovascular electrophysiology JID - 9010756 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 15G12L5X8K (gadobenic acid) RN - 6HG8UB2MUY (Meglumine) SB - IM MH - Animals MH - Contrast Media/administration & dosage MH - Cryosurgery/*adverse effects MH - Dogs MH - Edema, Cardiac/*diagnostic imaging/etiology/pathology MH - Heart Ventricles/*diagnostic imaging/pathology/*surgery MH - *Magnetic Resonance Imaging MH - Meglumine/administration & dosage/analogs & derivatives MH - Myocardium/*pathology MH - Organometallic Compounds/administration & dosage MH - Predictive Value of Tests MH - Radiofrequency Ablation/*adverse effects MH - Time Factors PMC - PMC6363882 MID - NIHMS995678 OTO - NOTNLM OT - catheter ablation OT - cryoablation OT - late gadolinium enhancement OT - magnetic resonance imaging OT - radiofrequency EDAT- 2018/10/31 06:00 MHDA- 2020/03/13 06:00 PMCR- 2020/02/01 CRDT- 2018/10/31 06:00 PHST- 2018/09/05 00:00 [received] PHST- 2018/10/16 00:00 [revised] PHST- 2018/10/23 00:00 [accepted] PHST- 2018/10/31 06:00 [pubmed] PHST- 2020/03/13 06:00 [medline] PHST- 2018/10/31 06:00 [entrez] PHST- 2020/02/01 00:00 [pmc-release] AID - 10.1111/jce.13785 [doi] PST - ppublish SO - J Cardiovasc Electrophysiol. 2019 Feb;30(2):255-262. doi: 10.1111/jce.13785. Epub 2018 Nov 21.