PMID- 30375290
OWN - NLM
STAT- MEDLINE
DCOM- 20190909
LR  - 20220408
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Print)
IS  - 0007-1145 (Linking)
VI  - 120
IP  - 11
DP  - 2018 Dec
TI  - A diet high in sugar-sweetened beverage and low in fruits and vegetables is 
      associated with adiposity and a pro-inflammatory adipokine profile.
PG  - 1230-1239
LID - 10.1017/S0007114518002726 [doi]
AB  - Diet, obesity and adipokines play important roles in diabetes and CVD; yet, 
      limited studies have assessed the relationship between diet and multiple 
      adipokines. This cross-sectional study assessed associations between diet, 
      adiposity and adipokines in Mexican Americans. The cohort included 1128 
      participants (age 34.7+/-8.2 years, BMI 29.5+/-5.9 kg/m2, 73.2 % female). Dietary 
      intake was assessed by 12-month food frequency questionnaire. Adiposity was 
      measured by BMI, total percentage body fat and percentage trunk fat using 
      dual-energy X-ray absorptiometry. Adiponectin, apelin, C-reactive protein (CRP), 
      dipeptidyl peptidase-4 (DPP-IV), IL-1beta, IL-1ra, IL-6, IL-18, leptin, lipocalin, 
      monocyte chemo-attractant protein-1 (MCP-1), resistin, secreted frizzled protein 
      4 (SFRP-4), SFRP-5, TNF-alpha and visfatin were assayed with multiplex kits or ELISA. 
      Joint multivariate associations between diet, adiposity and adipokines were 
      analysed using canonical correlations adjusted for age, sex, energy intake and 
      kinship. The median (interquartile range) energy intake was 9514 (7314, 11912) 
      kJ/d. Overall, 55 % of total intake was accounted for by carbohydrates (24 % from 
      sugar). A total of 66 % of the shared variation between diet and adiposity, and 
      34 % of diet and adipokines were explained by the top canonical correlation. The 
      diet component was most represented by sugar-sweetened beverages (SSB), fruit and 
      vegetables. Participants consuming a diet high in SSB and low in fruits and 
      vegetables had higher adiposity, CRP, leptin, and MCP-1, but lower SFRP-5 than 
      participants with high fruit and vegetable and low SSB intake. In Mexican 
      Americans, diets high in SSB but low in fruits and vegetables contribute to 
      adiposity and a pro-inflammatory adipokine profile.
FAU - Koebnick, Corinna
AU  - Koebnick C
AUID- ORCID: 0000-0001-8274-0309
AD  - 1Department of Research & Evaluation,Kaiser Permanente Southern 
      California,Pasadena,CA,USA.
FAU - Black, Mary Helen
AU  - Black MH
AD  - 1Department of Research & Evaluation,Kaiser Permanente Southern 
      California,Pasadena,CA,USA.
FAU - Wu, Jun
AU  - Wu J
AD  - 1Department of Research & Evaluation,Kaiser Permanente Southern 
      California,Pasadena,CA,USA.
FAU - Shu, Yu-Hsiang
AU  - Shu YH
AD  - 1Department of Research & Evaluation,Kaiser Permanente Southern 
      California,Pasadena,CA,USA.
FAU - MacKay, Adrienne W
AU  - MacKay AW
AD  - 2Department of Preventive Medicine,Keck School of Medicine,University of Southern 
      California,Los Angeles,CA,USA.
FAU - Watanabe, Richard M
AU  - Watanabe RM
AD  - 2Department of Preventive Medicine,Keck School of Medicine,University of Southern 
      California,Los Angeles,CA,USA.
FAU - Buchanan, Thomas A
AU  - Buchanan TA
AD  - 3USC Diabetes and Obesity Research Institute,University of Southern 
      California,Los Angeles,CA,USA.
FAU - Xiang, Anny H
AU  - Xiang AH
AD  - 1Department of Research & Evaluation,Kaiser Permanente Southern 
      California,Pasadena,CA,USA.
LA  - eng
GR  - R01 DK061628/DK/NIDDK NIH HHS/United States
GR  - R01 DK100302/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20181030
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Adipokines)
RN  - 0 (Dietary Sugars)
RN  - 0 (Nutritive Sweeteners)
SB  - IM
MH  - Adipokines/*blood
MH  - Adipose Tissue/metabolism
MH  - Adiposity/*ethnology
MH  - Adult
MH  - *Beverages
MH  - *Diet
MH  - Dietary Sugars/*administration & dosage
MH  - Energy Intake
MH  - Female
MH  - Fruit
MH  - Humans
MH  - Inflammation/metabolism
MH  - Male
MH  - Mexican Americans
MH  - Nutritive Sweeteners/administration & dosage
MH  - Obesity/*ethnology/prevention & control
MH  - Vegetables
MH  - Young Adult
PMC - PMC6261668
MID - NIHMS1505546
OTO - NOTNLM
OT  - CCA canonical correlation analysis
OT  - CRP C-reactive protein
OT  - DPP-IV dipeptidyl peptidase-4
OT  - GDM gestational diabetes mellitus
OT  - HighSSB/LowFV high in sugar-sweetened beverages and low in fruit and vegetables
OT  - LowSSB/HighFV low in sugar-sweetened beverages and high in fruit and vegetables
OT  - MCP-1 monocyte chemo-attractant protein-1
OT  - SFRP secreted frizzled protein
OT  - SSB sugar-sweetened beverages
OT  - Adipokines
OT  - Adiposity
OT  - Fruit
OT  - Sugar-sweetened beverages
OT  - Vegetables
COIS- Conflict of Interest: The authors have no potential conflicts of interest 
      relevant to this article.
EDAT- 2018/10/31 06:00
MHDA- 2019/09/10 06:00
PMCR- 2018/12/01
CRDT- 2018/10/31 06:00
PHST- 2018/10/31 06:00 [pubmed]
PHST- 2019/09/10 06:00 [medline]
PHST- 2018/10/31 06:00 [entrez]
PHST- 2018/12/01 00:00 [pmc-release]
AID - S0007114518002726 [pii]
AID - 10.1017/S0007114518002726 [doi]
PST - ppublish
SO  - Br J Nutr. 2018 Dec;120(11):1230-1239. doi: 10.1017/S0007114518002726. Epub 2018 
      Oct 30.