PMID- 30376345
OWN - NLM
STAT- MEDLINE
DCOM- 20200219
LR  - 20211204
IS  - 1535-3907 (Electronic)
IS  - 1535-3893 (Linking)
VI  - 18
IP  - 1
DP  - 2019 Jan 4
TI  - NMR-Based Serum Metabolomics Revealed Distinctive Metabolic Patterns in Reactive 
      Arthritis Compared with Rheumatoid Arthritis.
PG  - 130-146
LID - 10.1021/acs.jproteome.8b00439 [doi]
AB  - Reactive arthritis (ReA) is a member of seronegative spondyloarthropathy (SSA), 
      which involves an acute/subacute onset of asymmetrical lower limb joint 
      inflammation weeks after a genitourinary/gastrointestinal infection. The 
      diagnosis is clinical because it is difficult to culture the microbes from 
      synovial fluid. Arthritis patients with a similar clinical picture but lapsed 
      history of an immediate preceding infection that do not fulfill the diagnostic 
      criteria of other members of SSA, such as ankylosing spondylitis, psoriatic 
      arthritis, and arthritis associated with inflammatory bowel disease, are labeled 
      as peripheral undifferentiated spondyloarthropathy (uSpA). Both ReA and uSpA 
      patients show a strong association with class I major histocompatibility complex 
      allele, HLA-B27, and a clear association with an infectious trigger; however, the 
      disease mechanism is far from clear. Because the clinical picture is largely 
      dominated by rheumatoid-arthritis (RA)-like features including elevated levels of 
      inflammatory markers (such as ESR, CRP, etc.), these overlapping symptoms often 
      confound the clinical diagnosis and represent a clinical dilemma, making 
      treatment choice more generalized. Therefore, there is a compelling need to 
      identify biomarkers that can support the diagnosis of ReA/uSpA. In the present 
      study, we performed NMR-based serum metabolomics analysis and demonstrated that 
      ReA/uSpA patients are clearly distinguishable from controls and further that 
      these patients can also be distinguished from the RA patients based on the 
      metabolic profiles, with high sensitivity and specificity. The discriminatory 
      metabolites were further subjected to area under receiver operating 
      characteristic curve analysis, which led to the identification of four metabolic 
      entities (i.e., valine, leucine, arginine/lysine, and phenylalanine) that could 
      differentiate ReA/uSpA from RA.
FAU - Dubey, Durgesh
AU  - Dubey D
AD  - Babasaheb Bhimrao Ambedkar University , Lucknow 226025 , India.
FAU - Kumar, Sandeep
AU  - Kumar S
FAU - Chaurasia, Smriti
AU  - Chaurasia S
FAU - Guleria, Anupam
AU  - Guleria A
AUID- ORCID: 0000-0002-4158-2241
FAU - Ahmed, Sakir
AU  - Ahmed S
FAU - Singh, Rajeev
AU  - Singh R
AD  - National Institute of Virology , Gorkhpur Unit , BRD Medical College Campus , 
      Gorakhpur 273013 , India.
AD  - Department of Biochemistry , KGMU , Lucknow 226003 , India.
FAU - Kumari, Reena
AU  - Kumari R
AD  - Department of Biochemistry , KGMU , Lucknow 226003 , India.
FAU - Modi, Dinesh Raj
AU  - Modi DR
AD  - Babasaheb Bhimrao Ambedkar University , Lucknow 226025 , India.
FAU - Misra, Ramnath
AU  - Misra R
AUID- ORCID: 0000-0001-7921-4199
FAU - Kumar, Dinesh
AU  - Kumar D
AUID- ORCID: 0000-0001-8079-6739
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181030
PL  - United States
TA  - J Proteome Res
JT  - Journal of proteome research
JID - 101128775
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (PHB2 protein, human)
RN  - 0 (Prohibitins)
RN  - 47E5O17Y3R (Phenylalanine)
RN  - 94ZLA3W45F (Arginine)
RN  - GMW67QNF9C (Leucine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Arginine/analysis
MH  - Arthritis, Reactive/diagnosis/*metabolism
MH  - Arthritis, Rheumatoid/diagnosis/*metabolism
MH  - HLA-B27 Antigen
MH  - Humans
MH  - Leucine/analysis
MH  - Magnetic Resonance Imaging/methods
MH  - Metabolomics/*methods
MH  - Phenylalanine/analysis
MH  - Prohibitins
MH  - Serum/*metabolism
MH  - Spondylarthropathies/classification/diagnosis
MH  - Valine/analysis
OTO - NOTNLM
OT  - NMR
OT  - differential diagnosis
OT  - metabolic signatures
OT  - reactive arthritis
OT  - rheumatoid arthritis
EDAT- 2018/10/31 06:00
MHDA- 2020/02/20 06:00
CRDT- 2018/10/31 06:00
PHST- 2018/10/31 06:00 [pubmed]
PHST- 2020/02/20 06:00 [medline]
PHST- 2018/10/31 06:00 [entrez]
AID - 10.1021/acs.jproteome.8b00439 [doi]
PST - ppublish
SO  - J Proteome Res. 2019 Jan 4;18(1):130-146. doi: 10.1021/acs.jproteome.8b00439. 
      Epub 2018 Oct 30.