PMID- 30376614
OWN - NLM
STAT- MEDLINE
DCOM- 20191212
LR  - 20191217
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Jan
TI  - Independent predictive factors for the persistence and tolerance of cow's milk 
      allergy.
PG  - 67-71
LID - 10.1002/alr.22227 [doi]
AB  - BACKGROUND: Cow's milk protein allergy (CMPA) is usually transient, with most 
      children tolerating ingested cow's milk by 3 years of age. This study aimed to 
      determine factors that promote or hindering the development of tolerance to CMPA. 
      METHODS: A logistic regression model was used to determine independent risk 
      factors associated with tolerance and persistence of CMPA. RESULT: A total of 178 
      children diagnosed with CMPA were included in the study. The patients' median age 
      was 32 months (minimum-maximum, 14 to 144 months), and their median follow-up 
      period was 30 months (minimum-maximum, 12 to 54 months). In the follow-up, CMPA 
      persisted in 62 (34.8%) patients. The patients were divided into 2 groups 
      according to patient's age. Group I was <3 years old and group II was >/=3 years 
      old. The factors independently associated with the persistence of CMPA for group 
      I were as follows: comorbid food allergies (p = 0.021), the presence of an 
      immunoglobulin E (IgE)-mediated reaction (p = 0.001), and respiratory system 
      symptoms (ie, tachypnea) (p = 0.036). The presence of gastrointestinal-related 
      discomfort (p = 0.001) was an independent risk factor associated with the 
      development of tolerance. The presence of comorbid food allergies (p = 0.03) was 
      the only independent predictive factor for CMPA persistence for group II. 
      CONCLUSION: The prognosis in cases of CMPA, a food allergy, is good, with 
      tolerance developing over time. The presence of IgE-mediated CMPA, 
      respiratory-related symptoms (ie, tachypnea), and the presence of comorbid food 
      allergies have negative effects on tolerance.
CI  - (c) 2018 ARS-AAOA, LLC.
FAU - Topal, Erdem
AU  - Topal E
AD  - Faculty of Medicine, Department of Pediatric Allergy and Immunology, Inonu 
      University, Malatya, Turkey.
FAU - Celiksoy, Mehmet Halil
AU  - Celiksoy MH
AD  - Department of Pediatric Allergy and Immunology, GOP Taksim Education and Research 
      Hospital, Istanbul, Turkey.
FAU - Arga, Mustafa
AU  - Arga M
AD  - Faculty of Medicine, Department of Pediatric Allergy and Immunology, Medeniyet 
      University, Istanbul, Turkey.
FAU - Kaynak, Mustafa Sinan
AU  - Kaynak MS
AD  - Faculty of Pharmacy, Inonu University, Malatya, Turkey.
FAU - Duman, Yucel
AU  - Duman Y
AD  - Faculty of Medicine, Department of Microbiology, Inonu University, Malatya, 
      Turkey.
FAU - Demirtas, Semih
AU  - Demirtas S
AD  - Faculty of Medicine, Department of Pediatric Allergy and Immunology, Inonu 
      University, Malatya, Turkey.
FAU - Alatas, Cem
AU  - Alatas C
AD  - Faculty of Medicine, Department of Pediatric Allergy and Immunology, Inonu 
      University, Malatya, Turkey.
FAU - Tonbul, Hayrettin
AU  - Tonbul H
AD  - Faculty of Pharmacy, Inonu University, Malatya, Turkey.
FAU - Okmen, Zeynep Haziroglu
AU  - Okmen ZH
AD  - Department of Pediatric Allergy and Immunology, GOP Taksim Education and Research 
      Hospital, Istanbul, Turkey.
FAU - Dalkilic, Huri Maral
AU  - Dalkilic HM
AD  - Faculty of Medicine, Department of Pediatric Allergy and Immunology, Medeniyet 
      University, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20181030
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Female
MH  - Food Hypersensitivity/*epidemiology
MH  - Gastrointestinal Diseases/*epidemiology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Milk Hypersensitivity/*diagnosis/epidemiology
MH  - Prognosis
MH  - Risk Factors
MH  - Tachypnea
MH  - Turkey/epidemiology
OTO - NOTNLM
OT  - allergy
OT  - cow's milk
OT  - persistence
OT  - predictive factors
OT  - tolerance
EDAT- 2018/10/31 06:00
MHDA- 2019/12/18 06:00
CRDT- 2018/10/31 06:00
PHST- 2018/07/11 00:00 [received]
PHST- 2018/09/25 00:00 [revised]
PHST- 2018/09/26 00:00 [accepted]
PHST- 2018/10/31 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/10/31 06:00 [entrez]
AID - 10.1002/alr.22227 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2019 Jan;9(1):67-71. doi: 10.1002/alr.22227. Epub 2018 
      Oct 30.