PMID- 30376999
OWN - NLM
STAT- MEDLINE
DCOM- 20190408
LR  - 20191201
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Print)
IS  - 0160-4120 (Linking)
VI  - 121
IP  - Pt 2
DP  - 2018 Dec
TI  - Recent exposure to particle radioactivity and biomarkers of oxidative stress and 
      inflammation: The Framingham Heart Study.
PG  - 1210-1216
LID - S0160-4120(18)31534-4 [pii]
LID - 10.1016/j.envint.2018.10.039 [doi]
AB  - BACKGROUND: Decay products of radioactive materials may attach to ambient fine 
      particles and form radioactive aerosol. Internal ionizing radiation source from 
      inhaled radioactive aerosol may contribute to the fine particulate matter 
      (PM(2.5))-inflammation pathway. However, few studies in humans have examined the 
      associations. OBJECTIVES: To examine the associations between particle 
      radioactivity and biomarkers of oxidative stress and inflammation among 
      participants from the Framingham Offspring and Third Generation cohorts. METHODS: 
      We included 3996 participants who were not current smokers and lived within 50 km 
      from our central air pollution monitoring station. We estimated regional mean 
      gross beta radioactivity from monitors in the northeastern U.S. as a surrogate 
      for ambient radioactive particles, and calculated the 1- to 28-day moving 
      averages. We used linear regression models for fibrinogen, tumor necrosis factor 
      alpha, interleukin-6, and myeloperoxidase which were measured once, and linear mixed 
      effect models for 8-epi-prostaglandin F(2alpha), C-reactive protein, intercellular 
      adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1), 
      P-selectin, and tumor necrosis factor receptor-2 that were measured up to twice, 
      adjusting for demographics, individual- and area-level socioeconomic positions, 
      time, meteorology, and PM(2.5). We also examined whether the associations 
      differed by median age, sex, diabetes status, PM(2.5) levels, and black carbon 
      levels. RESULTS: The mean age was 54 years and 54% were women. An interquartile 
      range (3 x 10(-3) pCi/m(3)) higher beta radioactivity level at the 7-day moving 
      average was associated with 5.09% (95% CI: 0.92, 9.43), 2.65% (1.10, 4.22), and 
      4.71% (95% CI: 3.01, 6.44) higher levels of interleukin-6, MCP-1, and P-selectin, 
      but with 7.01% (95% CI: -11.64, -2.15) and 2.70% (95% CI: -3.97, -1.42) lower 
      levels of 8-epi-prostaglandin F(2alpha) and ICAM-1, respectively. CONCLUSIONS: 
      Regional mean particle radioactivity was positively associated with 
      interleukin-6, MCP-1, and P-selectin, but negatively with ICAM-1 and 
      8-epi-prostaglandin F(2alpha) among our study participants.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Li, Wenyuan
AU  - Li W
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      MA, United States; Cardiovascular Epidemiology Research Unit, Division of 
      Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 
      MA, United States.
FAU - Nyhan, Marguerite M
AU  - Nyhan MM
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States.
FAU - Wilker, Elissa H
AU  - Wilker EH
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      MA, United States; Cardiovascular Epidemiology Research Unit, Division of 
      Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 
      MA, United States.
FAU - Vieira, Carolina L Z
AU  - Vieira CLZ
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States.
FAU - Lin, Honghuang
AU  - Lin H
AD  - Department of Medicine, Boston University School of Medicine, Boston, MA, United 
      States.
FAU - Schwartz, Joel D
AU  - Schwartz JD
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      MA, United States; Department of Environmental Health, Harvard T.H. Chan School 
      of Public Health, Boston, MA, United States.
FAU - Gold, Diane R
AU  - Gold DR
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States; Channing Division of Network Medicine, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, MA, United States.
FAU - Coull, Brent A
AU  - Coull BA
AD  - Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, 
      MA, United States.
FAU - Aba, Abdulaziz Mansour
AU  - Aba AM
AD  - Kuwait Institute for Scientific Research, Kuwait City, Kuwait.
FAU - Benjamin, Emelia J
AU  - Benjamin EJ
AD  - Department of Medicine, Boston University School of Medicine, Boston, MA, United 
      States; National Heart, Lung, and Blood Institute's and Boston University's 
      Framingham Heart Study, Framingham, MA, United States; Department of 
      Epidemiology, Boston University School of Public Health, Boston, MA, United 
      States.
FAU - Vasan, Ramachandran S
AU  - Vasan RS
AD  - Department of Medicine, Boston University School of Medicine, Boston, MA, United 
      States; National Heart, Lung, and Blood Institute's and Boston University's 
      Framingham Heart Study, Framingham, MA, United States; Department of 
      Epidemiology, Boston University School of Public Health, Boston, MA, United 
      States.
FAU - Koutrakis, Petros
AU  - Koutrakis P
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States.
FAU - Mittleman, Murray A
AU  - Mittleman MA
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      MA, United States; Cardiovascular Epidemiology Research Unit, Division of 
      Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 
      MA, United States. Electronic address: mmittlem@hsph.harvard.edu.
LA  - eng
GR  - P50 HL120163/HL/NHLBI NIH HHS/United States
GR  - P01 ES009825/ES/NIEHS NIH HHS/United States
GR  - HHSN268201500001C/HL/NHLBI NIH HHS/United States
GR  - R01 HL092577/HL/NHLBI NIH HHS/United States
GR  - P30 ES000002/ES/NIEHS NIH HHS/United States
GR  - R01 HL076784/HL/NHLBI NIH HHS/United States
GR  - R00 ES022243/ES/NIEHS NIH HHS/United States
GR  - R01 HL128914/HL/NHLBI NIH HHS/United States
GR  - HHSN268201500001I/HL/NHLBI NIH HHS/United States
GR  - N01HC25195/HL/NHLBI NIH HHS/United States
GR  - R01 AG028321/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20181028
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Aerosols)
RN  - 0 (Air Pollutants, Radioactive)
RN  - 0 (Biomarkers)
RN  - 0 (Particulate Matter)
RN  - 0 (Soot)
SB  - IM
MH  - Aerosols
MH  - Air Pollutants, Radioactive/*toxicity
MH  - Biomarkers/*blood
MH  - Environmental Exposure
MH  - Female
MH  - Humans
MH  - Inflammation/blood/*chemically induced
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Particulate Matter/toxicity
MH  - Soot
PMC - PMC6279550
MID - NIHMS1510996
OTO - NOTNLM
OT  - Environment
OT  - Epidemiology
OT  - Gross beta radiation
OT  - Inflammation
OT  - Oxidative stress
OT  - Particle radioactivity
COIS- Disclosures: The authors declare they have no actual or potential competing 
      financial interests.
EDAT- 2018/11/01 06:00
MHDA- 2019/04/09 06:00
PMCR- 2019/12/01
CRDT- 2018/11/01 06:00
PHST- 2018/07/16 00:00 [received]
PHST- 2018/10/17 00:00 [revised]
PHST- 2018/10/19 00:00 [accepted]
PHST- 2018/11/01 06:00 [pubmed]
PHST- 2019/04/09 06:00 [medline]
PHST- 2018/11/01 06:00 [entrez]
PHST- 2019/12/01 00:00 [pmc-release]
AID - S0160-4120(18)31534-4 [pii]
AID - 10.1016/j.envint.2018.10.039 [doi]
PST - ppublish
SO  - Environ Int. 2018 Dec;121(Pt 2):1210-1216. doi: 10.1016/j.envint.2018.10.039. 
      Epub 2018 Oct 28.