PMID- 30377258
OWN - NLM
STAT- MEDLINE
DCOM- 20191112
LR  - 20200309
IS  - 1470-7926 (Electronic)
IS  - 1351-0711 (Print)
IS  - 1351-0711 (Linking)
VI  - 76
IP  - 3
DP  - 2019 Mar
TI  - Urinary 2,5-dicholorophenol and 2,4-dichlorophenol concentrations and prevalent 
      disease among adults in the National Health and Nutrition Examination Survey 
      (NHANES).
PG  - 181-188
LID - 10.1136/oemed-2018-105278 [doi]
AB  - OBJECTIVE: To test cross-sectional associations between urinary concentrations of 
      2,5-dichlorophenol (2,5-DCP) and 2,4-dichlorophenol (2,4-DCP) with the prevalence 
      of cardiovascular disease (CVD), cancer, lung disease, thyroid problems and liver 
      conditions. METHODS: Logistic regression was used to evaluate associations of 
      urinary concentrations of 2,5-DCP and 2,4-DCP with prevalence of various medical 
      conditions among 3617 National Health and Nutrition Examination Survey 
      participants from 2007-2008 and 2009-2010. ORs and 95% CIs for each disease were 
      estimated. All regression models were adjusted for urinary creatinine. RESULTS: 
      We observed a monotonically increasing association between quartiles of 2,5-DCP 
      and prevalence of CVD. After adjustment for sociodemographic and lifestyle 
      characteristics, participants with the highest versus lowest quartile of urinary 
      2,5-DCP had an OR=1.84 (95% CI 1.26 to 2.70) (p linear trend=0.006). The 
      association was similar with further adjustment for established clinical CVD risk 
      factors. Higher 2,5-DCP was also associated with prevalence of all cancers 
      combined (OR(Q4 vs Q1)=1.50 (95% CI 1.00 to 2.26); p trend=0.05) and, in 
      exploratory analyses, with gynaecological cancers (OR(Q4 vs Q1)=4.15 (95% CI 1.51 
      to 11.40; p trend=0.01)). No associations were detected between 2,5-DCP and lung 
      diseases, thyroid problems or liver conditions, nor between 2,4-DCP and prevalent 
      disease. CONCLUSION: In this nationally representative study, higher urinary 
      2,5-DCP concentrations were associated with greater prevalence of CVD and all 
      cancers combined. Further examination may be warranted to assess whether chronic 
      exposure to 2,5-DCP is associated with incidence of adverse health outcomes.
CI  - (c) Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Rooney, Mary R
AU  - Rooney MR
AUID- ORCID: 0000-0002-5607-4848
AD  - Division of Epidemiology and Community Health, University of Minnesota, 
      Minneapolis, Minnesota, USA.
FAU - Lutsey, Pamela L
AU  - Lutsey PL
AD  - Division of Epidemiology and Community Health, University of Minnesota, 
      Minneapolis, Minnesota, USA.
FAU - Bhatti, Parveen
AU  - Bhatti P
AD  - Cancer Control Research, British Columbia Cancer Agency, Vancouver, British 
      Columbia, Canada.
AD  - Program in Epidemiology, Public Health Sciences Divisions, Fred Hutchinson Cancer 
      Research Center, Seattle, Washington, USA.
FAU - Prizment, Anna
AU  - Prizment A
AD  - Division of Epidemiology and Community Health, University of Minnesota, 
      Minneapolis, Minnesota, USA.
LA  - eng
GR  - T32 HL007779/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20181030
PL  - England
TA  - Occup Environ Med
JT  - Occupational and environmental medicine
JID - 9422759
RN  - 0 (Chlorophenols)
RN  - 0 (Pesticides)
RN  - 3B11G9AKBA (2,5-dichlorophenol)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Cardiovascular Diseases/epidemiology/*urine
MH  - Chlorophenols/adverse effects/*urine
MH  - Cross-Sectional Studies
MH  - Environmental Exposure/adverse effects/*analysis
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/epidemiology/*urine
MH  - Nutrition Surveys
MH  - Pesticides/adverse effects/*urine
MH  - Prevalence
MH  - United States/epidemiology
PMC - PMC6377840
MID - NIHMS1511965
OTO - NOTNLM
OT  - cancer
OT  - cardiovascular
OT  - cross sectional studies
OT  - endocrine disrupters
OT  - epidemiology
COIS- Competing interests: None declared.
EDAT- 2018/11/01 06:00
MHDA- 2019/11/13 06:00
PMCR- 2020/03/01
CRDT- 2018/11/01 06:00
PHST- 2018/06/06 00:00 [received]
PHST- 2018/10/08 00:00 [revised]
PHST- 2018/10/15 00:00 [accepted]
PHST- 2018/11/01 06:00 [pubmed]
PHST- 2019/11/13 06:00 [medline]
PHST- 2018/11/01 06:00 [entrez]
PHST- 2020/03/01 00:00 [pmc-release]
AID - oemed-2018-105278 [pii]
AID - 10.1136/oemed-2018-105278 [doi]
PST - ppublish
SO  - Occup Environ Med. 2019 Mar;76(3):181-188. doi: 10.1136/oemed-2018-105278. Epub 
      2018 Oct 30.