PMID- 30377647 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2352-3409 (Electronic) IS - 2352-3409 (Linking) VI - 21 DP - 2018 Dec TI - Data of antihyperlipidaemic activity for methanolic extract of Tagetes patula Linn. flower head along with piperine, as bioavailability enhancer. PG - 587-597 LID - 10.1016/j.dib.2018.10.022 [doi] AB - The data present in this article is associated with influence of piperine (secondary metabolite) on the antihyperlipidemic and antioxidant activity of methanolic extract of Tagetes patula (METP). METP was evaluated for antihyperlipidemic and antioxidant potential. Phytoconstituents of METP were identified using gas chromatography linked with a mass spectrometer. in vivo antihyperlipidemic activity of METP at the dose of 200 and 400 mg/kg b. wt. and 200 and 400 mg/kg b. wt. along with piperine (20 mg/kg b. wt.) were evaluated by Propylthiouracil induced and Triton X-100 induced hyperlipidemia in rats. Propylthiouracil significantly increased the serum TC (p<0.01), TG (p<0.01), LDL (p<0.01) and VLDL (p<0.01) levels and induction of HDL (p<0.01) at a dose of 400 mg/kg b. wt. along with piperine. Triton X-100 at a single dose of i.p increased lipid levels within 48 h. Increased lipid levels were significantly reduced TC (p<0.01), TG (p<0.01), LDL (p<0.05) and VLDL (p<0.05) by METP at doses of 200 and 400 mg/kg b. wt. along with piperine. Current data were also supported by histological study of livers, Cord pattern of hepatocytes, few periportal lymphocytes in focal area observed in hyperlipidemic rats and hepatocyte, periportal and centrilobular region of liver appear normal in treated group. METP along with piperine (capability to enhance bioavailability and has a property of increasing oral absorption of drugs) showed promising antioxidant and antihyperlipidemic activity which suggests the further use of Tagetes patula extract for the management of hyperlipidemia and atherosclerosis. FAU - Nawale, Sneha AU - Nawale S AD - Department of Pharmacognosy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India. FAU - Padma Priya, K AU - Padma Priya K AD - Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India. FAU - Pranusha, P AU - Pranusha P AD - Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India. FAU - Ganga Raju, M AU - Ganga Raju M AD - Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India. LA - eng PT - Journal Article DEP - 20181013 PL - Netherlands TA - Data Brief JT - Data in brief JID - 101654995 PMC - PMC6202789 OTO - NOTNLM OT - ANOVA, Analysis of variance OT - Antihyperlipidemic activity OT - Bioavailability OT - CPCSEA, Committee for the purpose of control and supervision of experimentation on animals OT - GC-MS OT - GC-MS, gas chromatography and mass spectrometry OT - HDL, high density lipoprotein OT - IAEC, Institutional Animal Ethical Committee OT - LDL, low density lipoprotein OT - METP, Methanolic extract of Tagetes patula flower heads OT - NO, nitric oxide OT - OECD, Economic Cooperation and Development OT - PTU, propylthiouracil OT - Piperine OT - ROS, Reactive oxygen species OT - SEM, standard error of mean OT - TC, total cholesterol OT - TG, triglycerides OT - Tagetes patula OT - Triton X-100 OT - VLDL, very low density lipoprotein OT - b. wt, body weight OT - i.p, intraperitoneal OT - p.o, per oral EDAT- 2018/11/01 06:00 MHDA- 2018/11/01 06:01 PMCR- 2018/10/13 CRDT- 2018/11/01 06:00 PHST- 2018/05/14 00:00 [received] PHST- 2018/10/04 00:00 [revised] PHST- 2018/10/05 00:00 [accepted] PHST- 2018/11/01 06:00 [entrez] PHST- 2018/11/01 06:00 [pubmed] PHST- 2018/11/01 06:01 [medline] PHST- 2018/10/13 00:00 [pmc-release] AID - S2352-3409(18)31239-3 [pii] AID - 10.1016/j.dib.2018.10.022 [doi] PST - epublish SO - Data Brief. 2018 Oct 13;21:587-597. doi: 10.1016/j.dib.2018.10.022. eCollection 2018 Dec.