PMID- 30378374
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 36
IP  - 11
DP  - 2018 Nov 1
TI  - [Nano-titania-coated modified magnetic graphene oxide for pass-through cleanup of 
      chloramphenicol, thiamphenicol, and florfenicol in human blood].
PG  - 1112-1118
LID - 10.3724/SP.J.1123.2018.07007 [doi]
AB  - To develop a rapid, effective, and accurate method for the simultaneous 
      determination of chloramphenicol, thiamphenicol, and florfenicol in human blood 
      by pass-through cleanup solid-phase extraction combined with liquid 
      chromatography-tandem mass spectrometry (LC-MS/MS), novel nano-titania-coated 
      modified magnetic graphene oxide (TiO(2)-Mag-GO) is used as the PRiME 
      pass-through cleanup solid-phase extraction sorbent for the cleanup of blood 
      phospholipids. The chromatographic separation was performed on an Eclipse Plus 
      C18 column (100 mmx2.1 mm, 1.8 mum) using 0.08% (v/v) aqueous ammonia solution and 
      acetonitrile having aqueous ammonia (0.08%, v/v) as mobile phases. The tandem 
      mass spectrometer was operated using electrospray ion source (ESI) in the 
      multiple reaction monitoring (MRM) mode. The results showed that the linearities 
      were in the range of 0.1-10.0 mug/L with the determination coefficients (r(2)) 
      greater than 0.9990 for chloramphenicol, thiamphenicol, and florfenicol. The 
      limits of quantification (LOQs) (S/N>10) in the blood samples were between 0.056 
      and 0.082 mug/L and the recoveries ranged from 90.0% to 105% at three spiked 
      levels. Precision values expressed as relative standard deviations (RSDs) were in 
      the range of 1.2%-6.6%. The developed method can be used for routine analyses to 
      determine chloramphenicol, thiamphenicol, and florfenicol in clinical studies.
FAU - He, Shiwei
AU  - He S
AD  - Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
FAU - Zhao, Yonggang
AU  - Zhao Y
AD  - Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
AD  - Ningbo Municipal Center for Disease Control and Prevention, Ningbo 315010, China.
FAU - Zhu, Yan
AU  - Zhu Y
AD  - Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Oxides)
RN  - 0 (Phospholipids)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 66974FR9Q1 (Chloramphenicol)
RN  - 7782-42-5 (Graphite)
RN  - 9J97307Y1H (florfenicol)
RN  - D1JT611TNE (Titanium)
RN  - FLQ7571NPM (Thiamphenicol)
SB  - IM
MH  - Chloramphenicol/*blood
MH  - Chromatography, Liquid
MH  - Drug Residues
MH  - Graphite
MH  - Humans
MH  - Magnetics
MH  - Nanoparticles
MH  - Oxides
MH  - Phospholipids/blood
MH  - Solid Phase Extraction
MH  - Tandem Mass Spectrometry
MH  - Thiamphenicol/*analogs & derivatives/*blood
MH  - *Titanium
OTO - NOTNLM
OT  - chloramphenicol
OT  - florfenicol
OT  - human blood
OT  - liquid chromatography-tandem mass spectrometry (LC-MS/MS)
OT  - nano-titania-coated modified magnetic graphene oxide (TiO2-Mag-GO)
OT  - pass-through cleanup
OT  - thiamphenicol
EDAT- 2018/11/01 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/11/01 06:00
PHST- 2018/11/01 06:00 [entrez]
PHST- 2018/11/01 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
AID - 10.3724/SP.J.1123.2018.07007 [doi]
PST - ppublish
SO  - Se Pu. 2018 Nov 1;36(11):1112-1118. doi: 10.3724/SP.J.1123.2018.07007.