PMID- 30380818 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1738-3684 (Print) IS - 1976-3026 (Electronic) IS - 1738-3684 (Linking) VI - 15 IP - 11 DP - 2018 Oct TI - BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome. PG - 1094-1097 LID - 10.30773/pi.2018.09.20 [doi] AB - OBJECTIVE: Patients with acute coronary syndrome (ACS) are at an increased risk of suicide. It is well known that epigenetic mechanisms may explain the pathophysiology of suicidal behavior including suicidal ideation (SI), but no study has explored these mechanisms in ACS populations. METHODS: In total, 969 patients were initially recruited within 2 weeks of the acute coronary event and, 711 patients were successfully followed up 1 year after ACS. SI was evaluated using the relevant items on the Montgomery-Asberg Depression Rating Scale and covariates potentially affecting SI were estimated. RESULTS: Brain-derived neurotrophic factor (BDNF) hypermethylation was associated with SI in both the acute and chronic phases of ACS, although the association was not statistically significant in the acute phase after applying Bonferroni's correction. CONCLUSION: These results suggested that BDNF hypermethylation may have played a role in an epigenetic predisposition for SI in ACS patients, particularly during the chronic phase. FAU - Kang, Hee-Ju AU - Kang HJ AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea. FAU - Bae, Kyung-Yeol AU - Bae KY AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea. FAU - Kim, Sung-Wan AU - Kim SW AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea. FAU - Shin, Il-Seon AU - Shin IS AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea. FAU - Hong, Young Joon AU - Hong YJ AD - Department of Cardiology, Chonnam National University Medical School, Gwangju, Republic of Korea. FAU - Ahn, Youngkeun AU - Ahn Y AD - Department of Cardiology, Chonnam National University Medical School, Gwangju, Republic of Korea. FAU - Jeong, Myung Ho AU - Jeong MH AD - Department of Cardiology, Chonnam National University Medical School, Gwangju, Republic of Korea. FAU - Yoon, Jin-Sang AU - Yoon JS AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea. FAU - Kim, Jae-Min AU - Kim JM AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea. LA - eng GR - 2017M3A9E8023015/Chonnam National University/ PT - Journal Article DEP - 20181102 PL - Korea (South) TA - Psychiatry Investig JT - Psychiatry investigation JID - 101242994 PMC - PMC6259000 OTO - NOTNLM OT - Acute coronary syndrome OT - Brain-derived neurotrophic factor methylation OT - Longitudinal study OT - Suicidal ideation EDAT- 2018/11/02 06:00 MHDA- 2018/11/02 06:01 PMCR- 2018/11/01 CRDT- 2018/11/02 06:00 PHST- 2018/08/16 00:00 [received] PHST- 2018/09/20 00:00 [accepted] PHST- 2018/11/02 06:00 [pubmed] PHST- 2018/11/02 06:01 [medline] PHST- 2018/11/02 06:00 [entrez] PHST- 2018/11/01 00:00 [pmc-release] AID - pi.2018.09.20 [pii] AID - pi-2018-09-20 [pii] AID - 10.30773/pi.2018.09.20 [doi] PST - ppublish SO - Psychiatry Investig. 2018 Oct;15(11):1094-1097. doi: 10.30773/pi.2018.09.20. Epub 2018 Nov 2.