PMID- 30380879
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 34
IP  - 48
DP  - 2018 Dec 4
TI  - Insights into the Interactions of Sulfamethoxazole with Organized Assemblies of 
      Ionic and Nonionic Surfactants.
PG  - 14624-14632
LID - 10.1021/acs.langmuir.8b02814 [doi]
AB  - This work reports the physicochemical behavior of antibiotic drug 
      sulfamethoxazole (SMX) in the presence of different surfactants, viz., cetyl 
      trimethyl ammonium bromide (CTAB), dodecyl trimethyl ammonium bromide, didodecyl 
      dimethyl ammonium bromide, sodium dodecyl sulfate, sodium deoxycholate, Tween 80, 
      and Tween 20. The drug-surfactant systems were studied by UV-visible and 
      fluorescence spectroscopies to assess the binding constants ( K(b)), partition 
      coefficient ( K(x)), free energy of partition (Delta G(p)), aggregation number ( 
      N(agg)), and quenching constant ( K(SV)). Solubilization studies were carried out 
      to understand the encapsulation efficiency of the system, which was found to 
      increase as a function of CTAB concentration. Surface tension measurements 
      enabled us to determine the change in critical micelle concentration as well as 
      to calculate the variation in surface parameters of surfactant in the presence of 
      drug, viz., surface pressure (pi), surface excess concentration (gamma(max)), and 
      minimum area ( A(min)). In addition, UV-visible, fluorescence, and circular 
      dichroism studies were carried out to check the effects of surfactant-based SMX 
      formulation on serum proteins.
FAU - Saraf, Aparna
AU  - Saraf A
AD  - Department of Chemistry , University of Mumbai , Vidyanagari, Santacruz (E), 
      Mumbai 400098 , India.
FAU - Sharma, Shweta
AU  - Sharma S
AUID- ORCID: 0000-0002-1936-2947
AD  - Institute of Forensic Science & Criminology , Panjab University , Chandigarh 160 
      014 , India.
FAU - Sachar, Shilpee
AU  - Sachar S
AUID- ORCID: 0000-0001-6207-3756
AD  - Department of Chemistry , University of Mumbai , Vidyanagari, Santacruz (E), 
      Mumbai 400098 , India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181116
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
EDAT- 2018/11/02 06:00
MHDA- 2018/11/02 06:01
CRDT- 2018/11/02 06:00
PHST- 2018/11/02 06:00 [pubmed]
PHST- 2018/11/02 06:01 [medline]
PHST- 2018/11/02 06:00 [entrez]
AID - 10.1021/acs.langmuir.8b02814 [doi]
PST - ppublish
SO  - Langmuir. 2018 Dec 4;34(48):14624-14632. doi: 10.1021/acs.langmuir.8b02814. Epub 
      2018 Nov 16.