PMID- 30381793
OWN - NLM
STAT- MEDLINE
DCOM- 20191126
LR  - 20230928
IS  - 2046-1402 (Electronic)
IS  - 2046-1402 (Linking)
VI  - 7
DP  - 2018
TI  - Biomimetic remineralization of acid etched enamel using agarose hydrogel model.
PG  - 1476
LID - 10.12688/f1000research.16050.1 [doi]
LID - 1476
AB  - Background: Minimally invasive dentistry aims to prevent progression of caries 
      and treats non-cavitated lesions through non-invasive approaches to preserve the 
      integrity of tooth structure. The aim of this research was to investigate the 
      possible biomimetic effect of agarose hydrogel in remineralizing a human 
      demineralized enamel model. Methods: Mandibular third molars were distributed 
      into three groups (G1, G2 and G3) according to the follow up time (2, 4 and 6 
      days respectively). Caries like lesion was prepared by applying 37% phosphoric 
      acid gel for 1 minute and then remineralization was performed through applying 
      agarose hydrogel on the demineralized surfaces. The specimens were placed in 
      phosphate solution at 37 C for 2, 4 & 6 days. Scanning electron microscope (SEM), 
      surface microhardness (SMH) and surface roughness analysis (SR) were performed to 
      assess the regenerated tissue. Results: SEM revealed mineral depositions on the 
      demineralized enamel surface that increased in density by time resulting in a 
      relatively smooth surface in G3. SR and SMH analysis revealed significant 
      differences between the remineralized enamel surfaces of different groups (p< 
      0.00001) with the highest SR in G1 and the highest SMH in G3. Conclusions: 
      Agarose hydrogel application is a promising approach to treat early carious 
      lesion. Further studies are needed to clarify the stability of agarose hydrogels 
      in clinical application.
FAU - El Moshy, Sara
AU  - El Moshy S
AUID- ORCID: 0000-0002-2860-8523
AD  - Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, 11553, 
      Egypt.
FAU - Abbass, Marwa M S
AU  - Abbass MMS
AD  - Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, 11553, 
      Egypt.
FAU - El-Motayam, Amal M
AU  - El-Motayam AM
AD  - Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, 11553, 
      Egypt.
LA  - eng
PT  - Journal Article
DEP - 20180917
PL  - England
TA  - F1000Res
JT  - F1000Research
JID - 101594320
RN  - 0 (Hydrogels)
RN  - 9012-36-6 (Sepharose)
SB  - IM
MH  - *Biomimetics
MH  - Dental Enamel
MH  - Humans
MH  - Hydrogels
MH  - Sepharose
MH  - Tooth Remineralization
PMC - PMC6178904
OTO - NOTNLM
OT  - Remineralization
OT  - agarose
OT  - enamel
OT  - microhardness
OT  - surface roughness.
COIS- No competing interests were disclosed.
EDAT- 2018/11/02 06:00
MHDA- 2019/11/27 06:00
PMCR- 2018/09/17
CRDT- 2018/11/02 06:00
PHST- 2018/09/06 00:00 [accepted]
PHST- 2018/11/02 06:00 [entrez]
PHST- 2018/11/02 06:00 [pubmed]
PHST- 2019/11/27 06:00 [medline]
PHST- 2018/09/17 00:00 [pmc-release]
AID - 10.12688/f1000research.16050.1 [doi]
PST - epublish
SO  - F1000Res. 2018 Sep 17;7:1476. doi: 10.12688/f1000research.16050.1. eCollection 
      2018.