PMID- 30382323
OWN - NLM
STAT- MEDLINE
DCOM- 20190510
LR  - 20200225
IS  - 1432-1106 (Electronic)
IS  - 0014-4819 (Linking)
VI  - 237
IP  - 1
DP  - 2019 Jan
TI  - Searching for the inner self: evidence against a direct dependence of the 
      self-prioritization effect on the ventro-medial prefrontal cortex.
PG  - 247-256
LID - 10.1007/s00221-018-5413-1 [doi]
AB  - The processing of self-referential material is supposed to be located in the 
      medial prefrontal cortex (MPFC) and in particular in the ventro-medial prefrontal 
      cortex (VMPFC). A reliable method to assess effects of self-relevance is the 
      so-called matching paradigm in which the prioritization of newly learned 
      self-associations in comparison to non-self-relevant associations can be 
      measured. To assess the connection of activation in the VMPFC and 
      self-referential processing, we measured the self-prioritization effect (SPE) 
      before and after experimentally manipulating activation in the VMPFC. We applied 
      either excitatory or inhibitory stimulation to the VMPFC via transcranial direct 
      current stimulation (tDCS). In a sample of N = 65 healthy adults, we found a 
      significant SPE before and after both types of stimulation and, remarkably, no 
      systematic change of the SPE due to the stimulation. These results are evidential 
      against a direct dependence of the SPE from activation in the VMPFC, indicating 
      either that the SPE differs from other, more elaborate self-effects, and thereby 
      is processed in different brain areas, or that the connection of SPE and VMPFC is 
      correlational rather than causal.
FAU - Schafer, Sarah
AU  - Schafer S
AUID- ORCID: 0000-0002-2569-0883
AD  - Department of Cognitive Psychology and Statistics, University of Trier, 54286, 
      Trier, Germany. schaefers@uni-trier.de.
FAU - Frings, Christian
AU  - Frings C
AD  - Department of Cognitive Psychology and Statistics, University of Trier, 54286, 
      Trier, Germany.
LA  - eng
PT  - Journal Article
DEP - 20181031
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - *Brain Mapping
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Oxygen/blood
MH  - Prefrontal Cortex/diagnostic imaging/*physiology
MH  - Reaction Time/physiology
MH  - *Self Concept
MH  - Transcranial Direct Current Stimulation
MH  - Young Adult
OTO - NOTNLM
OT  - Attention
OT  - Self
OT  - Self-prioritization
OT  - Transcranial direct current stimulation (tDCS)
EDAT- 2018/11/02 06:00
MHDA- 2019/05/11 06:00
CRDT- 2018/11/02 06:00
PHST- 2018/07/09 00:00 [received]
PHST- 2018/10/21 00:00 [accepted]
PHST- 2018/11/02 06:00 [pubmed]
PHST- 2019/05/11 06:00 [medline]
PHST- 2018/11/02 06:00 [entrez]
AID - 10.1007/s00221-018-5413-1 [pii]
AID - 10.1007/s00221-018-5413-1 [doi]
PST - ppublish
SO  - Exp Brain Res. 2019 Jan;237(1):247-256. doi: 10.1007/s00221-018-5413-1. Epub 2018 
      Oct 31.