PMID- 30382579
OWN - NLM
STAT- MEDLINE
DCOM- 20200408
LR  - 20240102
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 234
IP  - 5
DP  - 2019 May
TI  - Long noncoding RNA DLEU1 aggravates pancreatic ductal adenocarcinoma 
      carcinogenesis via the miR-381/CXCR4 axis.
PG  - 6746-6757
LID - 10.1002/jcp.27421 [doi]
AB  - Recent evidence has highlighted that long noncoding RNAs (lncRNA) are associated 
      with many diseases, particularly cancer. However, current understanding of the 
      lncRNA deleted in lymphocytic leukemia 1 (DLEU1) in pancreatic ductal 
      adenocarcinoma (PDAC) remains limited. Our studies indicated that the DLEU1 
      expression level was upregulated in PDAC tissue samples compared with adjacent 
      normal tissue. Moreover, the aberrant overexpression of DLEU1 indicated poor 
      prognosis of patients with PDAC. Loss-of-function experiments revealed that DLEU1 
      knockdown inhibited the proliferation, migration, and invasion of PDAC cells in 
      vitro and decreased tumor growth in vivo. Bioinformatics analysis predicted that 
      miR-381 potentially targeted the DLEU1 3'-untranslated region (UTR), suggesting 
      an interaction between miR-381 and DLEU1. Furthermore, miR-381 also targeted the 
      chemokine receptor-4 (CXCR4) messenger RNA 3'-UTR, which was validated by 
      luciferase reporter assay. Taken together, our study demonstrated the oncogenic 
      role of DLEU1 in clinical PDAC specimens and cellular experiments, showing the 
      potential involvement of DLEU1/miR-381/CXCR4 pathway. These results provide novel 
      insight into PDAC tumorigenesis.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Gao, Song
AU  - Gao S
AD  - Department of Oncology, Shanghai Tenths People's Hospital, Tongji University, 
      Shanghai, China.
AD  - Tongji University Cancer Center, Shanghai, China.
FAU - Cai, Yunyun
AU  - Cai Y
AD  - Department of Integrated Traditional Western Medicine, Minhang Branch of Fudan 
      University of Shanghai Cancer Center, Shanghai, China.
FAU - Zhang, Hu
AU  - Zhang H
AD  - Shanghai Geriatric Institute of Chinese Medicine, Longhua Hospital, Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
FAU - Hu, Fei
AU  - Hu F
AD  - Department of Oncology, Shanghai Tenths People's Hospital, Tongji University, 
      Shanghai, China.
AD  - Tongji University Cancer Center, Shanghai, China.
FAU - Hou, Lengchen
AU  - Hou L
AD  - Department of Anesthesiology, Shanghai 10th People's Hospital, Tongji University, 
      Shanghai, China.
FAU - Xu, Qing
AU  - Xu Q
AUID- ORCID: 0000-0002-7107-5451
AD  - Department of Oncology, Shanghai Tenths People's Hospital, Tongji University, 
      Shanghai, China.
AD  - Tongji University Cancer Center, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181101
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (CXCR4 protein, human)
RN  - 0 (DLEU1 lncRNA, human)
RN  - 0 (MIRN381 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Receptors, CXCR4)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinogenesis/genetics
MH  - Carcinoma, Pancreatic Ductal/*genetics/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - Humans
MH  - Male
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - Pancreatic Neoplasms/*genetics
MH  - RNA, Long Noncoding/*genetics
MH  - Receptors, CXCR4/*genetics
MH  - Tumor Suppressor Proteins/*genetics
OTO - NOTNLM
OT  - CXCR4
OT  - long noncoding RNAs (lncRNA) DLEU1
OT  - miR-381
OT  - pancreatic ductal adenocarcinoma (PADC)
EDAT- 2018/11/02 06:00
MHDA- 2020/04/09 06:00
CRDT- 2018/11/02 06:00
PHST- 2018/05/17 00:00 [received]
PHST- 2018/08/21 00:00 [accepted]
PHST- 2018/11/02 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2018/11/02 06:00 [entrez]
AID - 10.1002/jcp.27421 [doi]
PST - ppublish
SO  - J Cell Physiol. 2019 May;234(5):6746-6757. doi: 10.1002/jcp.27421. Epub 2018 Nov 
      1.