PMID- 30383195
OWN - NLM
STAT- MEDLINE
DCOM- 20190506
LR  - 20190506
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 59
IP  - 12
DP  - 2018 Oct 1
TI  - Drusen and Age-Related Scattered Hypofluorescent Spots on Late-Phase Indocyanine 
      Green Angiography, a Candidate Correlate of Lipid Accumulation.
PG  - 5237-5245
LID - 10.1167/iovs.18-25124 [doi]
AB  - PURPOSE: Age-related scattered hypofluorescent spots on late-phase indocyanine 
      green angiography (ASHS-LIA) might represent fundus aging and neutral lipid 
      accumulation. The present study was conducted to determine the association 
      between drusen and ASHS-LIA and to provide further evidence for our hypothesis. 
      METHODS: Patients who underwent indocyanine green angiography (ICGA), fundus 
      fluorescein angiography (FFA), and spectral-domain optical coherence tomography 
      (SD-OCT) at the Zhongshan Ophthalmic Center from January 2014 to March 2018 were 
      reviewed. Patients with soft drusen or ASHS-LIA in the fellow eyes were included 
      in this study. RESULTS: A total of 345 patients aged 33 to 87 years (mean: 66.1 +/- 
      8.4 years) were included in this study. Results showed that all patients had 
      ASHS-LIA, among them, 70 patients (20.3%) had concurrent soft drusen, while 156 
      patients (45.2%) had concurrent hard drusen. Furthermore, the incidence of soft 
      drusen was 8.9% (10/112), 21.2% (41/193), and 47.5% (19/40), respectively, in the 
      different grades of ASHS-LIA and significantly increased with the grade of 
      ASHS-LIA (all P < 0.01). In addition, soft drusen were located inside the 
      ASHS-LIA in all cases and both soft drusen and ASHS-LIA presented as 
      hypofluorescence on late-phase ICGA, while hard drusen were located outside the 
      ASHS-LIA and presented as hyperfluorescence on late-phase ICGA. CONCLUSIONS: Soft 
      drusen might occur in the presence of ASHS-LIA, and were correlated with the 
      grade of ASHS-LIA. Based on the association between drusen and ASHS-LIA and their 
      ICGA characteristics, we hypothesized that ASHS-LIA might be a candidate 
      correlate of lipid accumulation in Bruch's membrane.
FAU - Chen, Ling
AU  - Chen L
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Zhang, Xiongze
AU  - Zhang X
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Li, Miaoling
AU  - Li M
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Gan, Yuhong
AU  - Gan Y
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Wen, Feng
AU  - Wen F
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Coloring Agents/*administration & dosage
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Indocyanine Green/*administration & dosage
MH  - *Lipid Metabolism
MH  - Macular Degeneration/*diagnosis/metabolism
MH  - Male
MH  - Middle Aged
MH  - Optical Imaging
MH  - Retinal Drusen/*diagnosis
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
EDAT- 2018/11/02 06:00
MHDA- 2019/05/07 06:00
CRDT- 2018/11/02 06:00
PHST- 2018/11/02 06:00 [entrez]
PHST- 2018/11/02 06:00 [pubmed]
PHST- 2019/05/07 06:00 [medline]
AID - 2711473 [pii]
AID - 10.1167/iovs.18-25124 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):5237-5245. doi: 
      10.1167/iovs.18-25124.