PMID- 30383327
OWN - NLM
STAT- MEDLINE
DCOM- 20190307
LR  - 20221207
IS  - 1365-2672 (Electronic)
IS  - 1364-5072 (Linking)
VI  - 126
IP  - 2
DP  - 2019 Feb
TI  - Interactions of organic acids with vancomycin-resistant Enterococcus faecium 
      isolated from community wastewater in Texas.
PG  - 480-488
LID - 10.1111/jam.14145 [doi]
AB  - AIMS: Investigate the interactions of organic acids (OAs), acetic, butyric, 
      citric, formic, lactic and propionic acid against 50 Gram-positive 
      vancomycin-resistant Enterococcus faecium (VRE) strains to determine whether pH, 
      undissociated or dissociated acid forms correlate with bacterial inhibition. 
      METHODS AND RESULTS: Concentrations of undissociated and dissociated OAs at the 
      molar minimum inhibitory concentrations (MIC(M) s) of the VRE were calculated 
      using the Henderson-Hasselbalch equation. The pH at the MIC(M) s of all VRE 
      strains against acetic, butyric, formic and propionic acids was similar, 
      4.66 +/- 0.07, but there was a 1.1 pH unit difference for all six OAs. Inhibition 
      of VRE by all six OAs did not appear to be solely dependent on pH or on the 
      undissociated OA species. The inhibition of VRE by all six dissociated acids was 
      within Delta = 3.1 mmol l(-1) . CONCLUSIONS: Vancomycin-resistant Enterococcus 
      faecium inhibition correlated with the dissociated OA species. A small decrease 
      in the concentration of the dissociated OAs from optimum may result in allowing 
      VRE strains to escape disinfection. SIGNIFICANCE AND IMPACT OF THE STUDY: When an 
      OA is used to disinfect VRE strains, the concentration of the dissociated OA 
      should be carefully controlled. A concentration of at least 20 mmol l(-1) 
      dissociated OA should be maintained when disinfecting VRE.
CI  - (c) 2018 The Society for Applied Microbiology.
FAU - Beier, R C
AU  - Beier RC
AUID- ORCID: 0000-0002-3445-1008
AD  - Food and Feed Safety Research Unit, United States Department of Agriculture, 
      Agricultural Research Service, Southern Plains Agricultural Research Center, 
      College Station, TX, USA.
FAU - Harvey, R B
AU  - Harvey RB
AD  - Food and Feed Safety Research Unit, United States Department of Agriculture, 
      Agricultural Research Service, Southern Plains Agricultural Research Center, 
      College Station, TX, USA.
FAU - Poole, T L
AU  - Poole TL
AD  - Food and Feed Safety Research Unit, United States Department of Agriculture, 
      Agricultural Research Service, Southern Plains Agricultural Research Center, 
      College Station, TX, USA.
FAU - Hume, M E
AU  - Hume ME
AD  - Food and Feed Safety Research Unit, United States Department of Agriculture, 
      Agricultural Research Service, Southern Plains Agricultural Research Center, 
      College Station, TX, USA.
FAU - Crippen, T L
AU  - Crippen TL
AD  - Food and Feed Safety Research Unit, United States Department of Agriculture, 
      Agricultural Research Service, Southern Plains Agricultural Research Center, 
      College Station, TX, USA.
FAU - Highfield, L D
AU  - Highfield LD
AD  - UTHealth School of Public Health, Houston, TX, USA.
FAU - Alali, W Q
AU  - Alali WQ
AD  - Department of Veterinary Medicine, College of Food and Agriculture, United Arab 
      Emirates University, Al Ain, United Arab Emirates.
FAU - Andrews, K
AU  - Andrews K
AD  - Food and Feed Safety Research Unit, United States Department of Agriculture, 
      Agricultural Research Service, Southern Plains Agricultural Research Center, 
      College Station, TX, USA.
FAU - Anderson, R C
AU  - Anderson RC
AD  - Food and Feed Safety Research Unit, United States Department of Agriculture, 
      Agricultural Research Service, Southern Plains Agricultural Research Center, 
      College Station, TX, USA.
FAU - Nisbet, D J
AU  - Nisbet DJ
AD  - Food and Feed Safety Research Unit, United States Department of Agriculture, 
      Agricultural Research Service, Southern Plains Agricultural Research Center, 
      College Station, TX, USA.
LA  - eng
GR  - USDA, Agricultural Research Service/
PT  - Journal Article
DEP - 20181126
PL  - England
TA  - J Appl Microbiol
JT  - Journal of applied microbiology
JID - 9706280
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Carboxylic Acids)
RN  - 0 (Disinfectants)
RN  - 0 (Waste Water)
SB  - IM
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Carboxylic Acids/pharmacology
MH  - Disinfectants/*pharmacology
MH  - Enterococcus faecium/*drug effects/isolation & purification
MH  - Hydrogen-Ion Concentration
MH  - Texas
MH  - Vancomycin-Resistant Enterococci/*drug effects
MH  - Wastewater/*microbiology
OTO - NOTNLM
OT  - acetic acid
OT  - citric acid
OT  - formic acid
OT  - lactic acid
OT  - molar minimum inhibitory concentrations
OT  - propionic acid
OT  - susceptibility
OT  - vancomycin-resistant Enterococcus faecium
EDAT- 2018/11/02 06:00
MHDA- 2019/03/08 06:00
CRDT- 2018/11/02 06:00
PHST- 2018/08/24 00:00 [received]
PHST- 2018/10/26 00:00 [revised]
PHST- 2018/10/29 00:00 [accepted]
PHST- 2018/11/02 06:00 [pubmed]
PHST- 2019/03/08 06:00 [medline]
PHST- 2018/11/02 06:00 [entrez]
AID - 10.1111/jam.14145 [doi]
PST - ppublish
SO  - J Appl Microbiol. 2019 Feb;126(2):480-488. doi: 10.1111/jam.14145. Epub 2018 Nov 
      26.