PMID- 30383667
OWN - NLM
STAT- MEDLINE
DCOM- 20181114
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 44
DP  - 2018 Nov
TI  - Pregnancy and pulmonary hypertension: An exploratory analysis of risk factors and 
      outcomes.
PG  - e13035
LID - 10.1097/MD.0000000000013035 [doi]
LID - e13035
AB  - Pregnancy is usually contraindicated in patients with pulmonary hypertension 
      (PH). Risk factors associated with the outcome of this rare disease have not been 
      specifically explored before.Medical records were retrospectively reviewed to 
      identify patients with coexisting PH and pregnancy or delivery at Peking Union 
      Medical College Hospital between January 2009 and June 2018. Demographics, 
      characteristics of PH and pregnancy, management and outcomes were 
      analyzed.Thirty-six pregnant women with PH were identified, including 30 cases in 
      WHO group 1, 5 cases of group 2 and 1 case of group 4. Median pregnancy duration 
      was 24 weeks. The overall maternal mortality rate was 8.3% (3/36), and the late 
      fetal mortality was 31.6% (6/19). Pulmonary vascular-targeted medications were 
      used in 17 of 26 patients with moderate or severe PH, but in none with mild PH. 
      Maternal mortality was 2/15, 1/11, and 0 among women with severe, moderate, and 
      mild PH, respectively. All deaths reported to be diagnosed of PH after pregnancy, 
      and have New York Heart Association (NYHA) grades II to IV. Cesarean section was 
      performed in 22 patients, and mortality was 3/16 among women receiving cesarean 
      section with general anesthesia.Maternal mortality is associated with PH 
      classification, severity of PH, delayed diagnosis of PH, and NYHA classification. 
      Regional anesthesia seems superior to general anesthesia for cesarean section.
FAU - Sun, Xuefeng
AU  - Sun X
AD  - Department of Respiratory Medicine.
FAU - Feng, Jun
AU  - Feng J
AD  - Department of Hematology, Peking Union Medical College Hospital, Beijing, China.
FAU - Shi, Juhong
AU  - Shi J
AD  - Department of Respiratory Medicine.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Female
MH  - Fetal Mortality
MH  - Humans
MH  - Hypertension, Pulmonary/drug therapy/*mortality
MH  - Infant, Newborn
MH  - *Maternal Mortality
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/drug therapy/*mortality
MH  - Pregnancy Outcome/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
PMC - PMC6221755
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2018/11/02 06:00
MHDA- 2018/11/15 06:00
PMCR- 2018/11/02
CRDT- 2018/11/02 06:00
PHST- 2018/11/02 06:00 [entrez]
PHST- 2018/11/02 06:00 [pubmed]
PHST- 2018/11/15 06:00 [medline]
PHST- 2018/11/02 00:00 [pmc-release]
AID - 00005792-201811020-00045 [pii]
AID - MD-D-18-05313 [pii]
AID - 10.1097/MD.0000000000013035 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Nov;97(44):e13035. doi: 10.1097/MD.0000000000013035.