PMID- 30384233
OWN - NLM
STAT- MEDLINE
DCOM- 20190912
LR  - 20210110
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 168
DP  - 2019 Jan
TI  - Urinary concentrations of parabens mixture and pregnancy glucose levels among 
      women from a fertility clinic.
PG  - 389-396
LID - S0013-9351(18)30543-7 [pii]
LID - 10.1016/j.envres.2018.10.009 [doi]
AB  - BACKGROUND: A number of endocrine disrupting chemicals (EDC) have been associated 
      with gestational diabetes (GDM) risk factors. However, no human study has 
      investigated the association between pregnancy exposure to parabens, a class of 
      EDCs, and pregnancy glucose levels, a risk factor for GDM. Furthermore, little is 
      known about this association in subfertile women-a group at high risk of GDM. 
      METHODS: A total of 241 women from the Environment and Reproductive Health Study 
      had data available on 1st and/or 2nd trimester urinary methylparaben, 
      propylparaben, and butylparaben concentrations, and blood glucose levels after 
      the glucose loading test (GLT), a non-fasting 50 g glucose loading test taken at 
      late 2nd trimester. Trimester-specific associations between specific gravity 
      adjusted methylparaben, butylparaben, and propylparaben with adjusted mean of 
      pregnancy glucose levels were evaluated in linear regression models, using 
      quartiles of each paraben's distribution, and as a paraben mixture, using mutual 
      adjustment and Bayesian kernel machine regression (BKMR), a recently proposed 
      method for investigating chemical mixtures that flexibly models the joint effect 
      of chemicals. RESULTS: Investigating parabens one at the time did not provide any 
      significant results. When investigating parabens as a chemical mixture with both 
      multiple regression and BKMR, we observed positive associations of butylparaben 
      (e.g comparing the 4th and 1st quartiles) with glucose levels, for both the 1st 
      trimester (adjusted difference=12.5 mg/dL; 95% CI: 0.9, 24.2) and 2nd trimester 
      (adjusted difference=11.2 mg/dL; 95% CI: 0.2, 22.3), and a negative association 
      between 1st trimester propylparaben and glucose (adjusted difference=-22.3 mg/dL; 
      95% CI: -43.2, -1.4). CONCLUSIONS: We found 1st trimester butylparaben and 
      propylparaben urinary concentrations to be associated with glucose levels in a 
      pregnancy cohort of women at high risk of GDM, even after adjusting for potential 
      confounders. Because exposure to parabens is widespread, these findings may 
      suggest further investigating the effects of this chemical class on pregnancy 
      health.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Bellavia, Andrea
AU  - Bellavia A
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States; Department of Biostatistics, Harvard T.H. Chan School 
      of Public Health, Boston, MA, United States.
FAU - Chiu, Yu-Han
AU  - Chiu YH
AD  - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 
      United States.
FAU - Brown, Florence M
AU  - Brown FM
AD  - Adult Diabetes Section, Joslin Diabetes Center, Boston, MA, United States.
FAU - Minguez-Alarcon, Lidia
AU  - Minguez-Alarcon L
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States.
FAU - Ford, Jennifer B
AU  - Ford JB
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States.
FAU - Keller, Myra
AU  - Keller M
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States.
FAU - Petrozza, John
AU  - Petrozza J
AD  - Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, 
      Boston, MA, United States.
FAU - Williams, Paige L
AU  - Williams PL
AD  - Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, 
      MA, United States; Department of Epidemiology, Harvard T.H. Chan School of Public 
      Health, Boston, MA, United States.
FAU - Ye, Xiaoyun
AU  - Ye X
AD  - National Center for Environmental Health, Centers for Disease Control and 
      Prevention, Atlanta, GA, United States.
FAU - Calafat, Antonia M
AU  - Calafat AM
AD  - National Center for Environmental Health, Centers for Disease Control and 
      Prevention, Atlanta, GA, United States.
FAU - Hauser, Russ
AU  - Hauser R
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States; Vincent Department of Obstetrics and Gynecology, 
      Massachusetts General Hospital, Boston, MA, United States; Department of 
      Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United 
      States.
FAU - James-Todd, Tamarra
AU  - James-Todd T
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan School 
      of Public Health, Boston, MA, United States. Electronic address: 
      tjtodd@hsph.harvard.edu.
CN  - EARTH Study Team
LA  - eng
GR  - P30 ES000002/ES/NIEHS NIH HHS/United States
GR  - R01 ES009718/ES/NIEHS NIH HHS/United States
GR  - R01 ES022955/ES/NIEHS NIH HHS/United States
GR  - R01 ES026166/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20181014
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Parabens)
SB  - IM
MH  - Bayes Theorem
MH  - *Diabetes, Gestational
MH  - Environmental Pollutants/*urine
MH  - Female
MH  - Humans
MH  - Maternal Exposure/*statistics & numerical data
MH  - Parabens/*metabolism
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - Pregnancy Trimester, Second
PMC - PMC7190006
MID - NIHMS1581509
OTO - NOTNLM
OT  - Endocrine disruptors, environmental epidemiology
OT  - Gestational diabetes
OT  - Glucose
OT  - Pregnancy, parabens
COIS- Conflict of interest: nothing to declare
EDAT- 2018/11/02 06:00
MHDA- 2019/09/13 06:00
PMCR- 2020/04/29
CRDT- 2018/11/02 06:00
PHST- 2018/07/10 00:00 [received]
PHST- 2018/10/05 00:00 [revised]
PHST- 2018/10/08 00:00 [accepted]
PHST- 2018/11/02 06:00 [pubmed]
PHST- 2019/09/13 06:00 [medline]
PHST- 2018/11/02 06:00 [entrez]
PHST- 2020/04/29 00:00 [pmc-release]
AID - S0013-9351(18)30543-7 [pii]
AID - 10.1016/j.envres.2018.10.009 [doi]
PST - ppublish
SO  - Environ Res. 2019 Jan;168:389-396. doi: 10.1016/j.envres.2018.10.009. Epub 2018 
      Oct 14.