PMID- 30385704
OWN - NLM
STAT- MEDLINE
DCOM- 20200626
LR  - 20220409
IS  - 1499-2752 (Electronic)
IS  - 0315-162X (Linking)
VI  - 46
IP  - 3
DP  - 2019 Mar
TI  - High Incidence of Arterial and Venous Thrombosis in Antineutrophil Cytoplasmic 
      Antibody-associated Vasculitis.
PG  - 285-293
LID - 10.3899/jrheum.170896 [doi]
AB  - OBJECTIVE: To determine the incidence of arterial thrombotic events (ATE) and 
      venous thromboembolism (VTE) in antineutrophil cytoplasmic antibody-associated 
      vasculitis (AAV). METHODS: This is a retrospective cohort study presenting the 
      incidence of ATE (coronary events or ischemic stroke) and VTE [pulmonary embolism 
      (PE) or deep venous thrombosis (DVT)] in patients diagnosed with AAV between 2005 
      and 2014. RESULTS: There were 204 patients with AAV who were identified. Median 
      followup for surviving patients was 5.8 (range 1-10) years, accounting for 1088 
      person-years (PY). The incidence of ATE was 2.67/100 PY (1.56 for coronary events 
      and 1.10 for ischemic stroke) and for VTE was 1.47/100 PY (0.83 for DVT only and 
      0.64 for PE with/without DVT). On multivariate analysis, prior ischemic heart 
      disease (IHD) and advancing age were the only independent predictors of ATE. 
      Among patients without prior IHD or stroke, the incidence of ATE remained 
      elevated at 2.32/100 PY (1.26 for coronary events and 1.06 for ischemic stroke). 
      ATE, but not VTE, was an independent predictor of all-cause mortality. Event 
      rates for both ATE and VTE were highest in the first year after diagnosis of AAV 
      but remained above the population incidence during the 10-year followup period. 
      In comparison to reported rates for the UK population, the event rates in our AAV 
      patients were 15-times higher for coronary events, 11-times higher for incident 
      stroke, and 20-times higher for VTE. CONCLUSION: Patients with AAV have a high 
      incidence of arterial and venous thrombosis, particularly in the first year after 
      diagnosis.
FAU - Kang, Amy
AU  - Kang A
AD  - From the Imperial College Renal and Transplant Centre, Imperial College 
      Healthcare UK National Health Service (NHS) Trust, London; Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London, London, 
      UK.
AD  - A. Kang, FRACP, MBBS (Hons), Clinical Fellow, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; M. Antonelou, MRCP, 
      BSc, Academic Clinical Fellow, Imperial College Renal and Transplant Centre, 
      Imperial College Healthcare NHS Trust; N.L. Wong, FRACP, MBBS, Clinical Research 
      Fellow, Imperial College Renal and Transplant Centre, Imperial College Healthcare 
      NHS Trust; A. Tanna, MBBS, BSc, Clinical Research Training Fellow, Renal and 
      Vascular Inflammation Section, Department of Medicine, Imperial College London; 
      N. Arulkumaran, PhD, MBBS, Renal Specialty Registrar, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; F.W. Tam, PhD, MB 
      BChir, Ken and Mary Minton Chair of Renal Medicine, Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London; C.D. 
      Pusey, DSc, MB BChir, Professor of Medicine, Renal and Vascular Inflammation 
      Section, Department of Medicine, Imperial College London.
FAU - Antonelou, Marilina
AU  - Antonelou M
AD  - From the Imperial College Renal and Transplant Centre, Imperial College 
      Healthcare UK National Health Service (NHS) Trust, London; Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London, London, 
      UK.
AD  - A. Kang, FRACP, MBBS (Hons), Clinical Fellow, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; M. Antonelou, MRCP, 
      BSc, Academic Clinical Fellow, Imperial College Renal and Transplant Centre, 
      Imperial College Healthcare NHS Trust; N.L. Wong, FRACP, MBBS, Clinical Research 
      Fellow, Imperial College Renal and Transplant Centre, Imperial College Healthcare 
      NHS Trust; A. Tanna, MBBS, BSc, Clinical Research Training Fellow, Renal and 
      Vascular Inflammation Section, Department of Medicine, Imperial College London; 
      N. Arulkumaran, PhD, MBBS, Renal Specialty Registrar, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; F.W. Tam, PhD, MB 
      BChir, Ken and Mary Minton Chair of Renal Medicine, Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London; C.D. 
      Pusey, DSc, MB BChir, Professor of Medicine, Renal and Vascular Inflammation 
      Section, Department of Medicine, Imperial College London.
FAU - Wong, Nikki L
AU  - Wong NL
AD  - From the Imperial College Renal and Transplant Centre, Imperial College 
      Healthcare UK National Health Service (NHS) Trust, London; Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London, London, 
      UK.
AD  - A. Kang, FRACP, MBBS (Hons), Clinical Fellow, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; M. Antonelou, MRCP, 
      BSc, Academic Clinical Fellow, Imperial College Renal and Transplant Centre, 
      Imperial College Healthcare NHS Trust; N.L. Wong, FRACP, MBBS, Clinical Research 
      Fellow, Imperial College Renal and Transplant Centre, Imperial College Healthcare 
      NHS Trust; A. Tanna, MBBS, BSc, Clinical Research Training Fellow, Renal and 
      Vascular Inflammation Section, Department of Medicine, Imperial College London; 
      N. Arulkumaran, PhD, MBBS, Renal Specialty Registrar, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; F.W. Tam, PhD, MB 
      BChir, Ken and Mary Minton Chair of Renal Medicine, Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London; C.D. 
      Pusey, DSc, MB BChir, Professor of Medicine, Renal and Vascular Inflammation 
      Section, Department of Medicine, Imperial College London.
FAU - Tanna, Anisha
AU  - Tanna A
AD  - From the Imperial College Renal and Transplant Centre, Imperial College 
      Healthcare UK National Health Service (NHS) Trust, London; Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London, London, 
      UK.
AD  - A. Kang, FRACP, MBBS (Hons), Clinical Fellow, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; M. Antonelou, MRCP, 
      BSc, Academic Clinical Fellow, Imperial College Renal and Transplant Centre, 
      Imperial College Healthcare NHS Trust; N.L. Wong, FRACP, MBBS, Clinical Research 
      Fellow, Imperial College Renal and Transplant Centre, Imperial College Healthcare 
      NHS Trust; A. Tanna, MBBS, BSc, Clinical Research Training Fellow, Renal and 
      Vascular Inflammation Section, Department of Medicine, Imperial College London; 
      N. Arulkumaran, PhD, MBBS, Renal Specialty Registrar, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; F.W. Tam, PhD, MB 
      BChir, Ken and Mary Minton Chair of Renal Medicine, Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London; C.D. 
      Pusey, DSc, MB BChir, Professor of Medicine, Renal and Vascular Inflammation 
      Section, Department of Medicine, Imperial College London.
FAU - Arulkumaran, Nishkantha
AU  - Arulkumaran N
AD  - From the Imperial College Renal and Transplant Centre, Imperial College 
      Healthcare UK National Health Service (NHS) Trust, London; Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London, London, 
      UK.
AD  - A. Kang, FRACP, MBBS (Hons), Clinical Fellow, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; M. Antonelou, MRCP, 
      BSc, Academic Clinical Fellow, Imperial College Renal and Transplant Centre, 
      Imperial College Healthcare NHS Trust; N.L. Wong, FRACP, MBBS, Clinical Research 
      Fellow, Imperial College Renal and Transplant Centre, Imperial College Healthcare 
      NHS Trust; A. Tanna, MBBS, BSc, Clinical Research Training Fellow, Renal and 
      Vascular Inflammation Section, Department of Medicine, Imperial College London; 
      N. Arulkumaran, PhD, MBBS, Renal Specialty Registrar, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; F.W. Tam, PhD, MB 
      BChir, Ken and Mary Minton Chair of Renal Medicine, Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London; C.D. 
      Pusey, DSc, MB BChir, Professor of Medicine, Renal and Vascular Inflammation 
      Section, Department of Medicine, Imperial College London.
FAU - Tam, Frederick W K
AU  - Tam FWK
AD  - From the Imperial College Renal and Transplant Centre, Imperial College 
      Healthcare UK National Health Service (NHS) Trust, London; Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London, London, 
      UK.
AD  - A. Kang, FRACP, MBBS (Hons), Clinical Fellow, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; M. Antonelou, MRCP, 
      BSc, Academic Clinical Fellow, Imperial College Renal and Transplant Centre, 
      Imperial College Healthcare NHS Trust; N.L. Wong, FRACP, MBBS, Clinical Research 
      Fellow, Imperial College Renal and Transplant Centre, Imperial College Healthcare 
      NHS Trust; A. Tanna, MBBS, BSc, Clinical Research Training Fellow, Renal and 
      Vascular Inflammation Section, Department of Medicine, Imperial College London; 
      N. Arulkumaran, PhD, MBBS, Renal Specialty Registrar, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; F.W. Tam, PhD, MB 
      BChir, Ken and Mary Minton Chair of Renal Medicine, Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London; C.D. 
      Pusey, DSc, MB BChir, Professor of Medicine, Renal and Vascular Inflammation 
      Section, Department of Medicine, Imperial College London.
FAU - Pusey, Charles D
AU  - Pusey CD
AD  - From the Imperial College Renal and Transplant Centre, Imperial College 
      Healthcare UK National Health Service (NHS) Trust, London; Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London, London, 
      UK. c.pusey@imperial.ac.uk.
AD  - A. Kang, FRACP, MBBS (Hons), Clinical Fellow, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; M. Antonelou, MRCP, 
      BSc, Academic Clinical Fellow, Imperial College Renal and Transplant Centre, 
      Imperial College Healthcare NHS Trust; N.L. Wong, FRACP, MBBS, Clinical Research 
      Fellow, Imperial College Renal and Transplant Centre, Imperial College Healthcare 
      NHS Trust; A. Tanna, MBBS, BSc, Clinical Research Training Fellow, Renal and 
      Vascular Inflammation Section, Department of Medicine, Imperial College London; 
      N. Arulkumaran, PhD, MBBS, Renal Specialty Registrar, Imperial College Renal and 
      Transplant Centre, Imperial College Healthcare NHS Trust; F.W. Tam, PhD, MB 
      BChir, Ken and Mary Minton Chair of Renal Medicine, Renal and Vascular 
      Inflammation Section, Department of Medicine, Imperial College London; C.D. 
      Pusey, DSc, MB BChir, Professor of Medicine, Renal and Vascular Inflammation 
      Section, Department of Medicine, Imperial College London. c.pusey@imperial.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20181101
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
SB  - IM
CIN - J Rheumatol. 2019 Jul;46(7):866-867. PMID: 31154407
CIN - J Rheumatol. 2019 Jul;46(7):866. PMID: 31154412
CIN - J Rheumatol. 2019 Sep;46(9):1244. PMID: 31263073
CIN - J Rheumatol. 2019 Sep;46(9):1243. PMID: 31263074
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*diagnosis
MH  - Arteries/pathology
MH  - Coronary Thrombosis/*epidemiology/mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Embolism/*epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Stroke/*epidemiology/mortality
MH  - United Kingdom/epidemiology
MH  - Venous Thromboembolism/*epidemiology
MH  - Venous Thrombosis/*epidemiology
OTO - NOTNLM
OT  - ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS
OT  - CARDIOVASCULAR DISEASE
OT  - MYOCARDIAL INFARCTION
OT  - STROKE
OT  - THROMBOSIS
OT  - VENOUS THROMBOEMBOLISM
EDAT- 2018/11/06 06:00
MHDA- 2020/06/27 06:00
CRDT- 2018/11/03 06:00
PHST- 2018/07/20 00:00 [accepted]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2020/06/27 06:00 [medline]
PHST- 2018/11/03 06:00 [entrez]
AID - jrheum.170896 [pii]
AID - 10.3899/jrheum.170896 [doi]
PST - ppublish
SO  - J Rheumatol. 2019 Mar;46(3):285-293. doi: 10.3899/jrheum.170896. Epub 2018 Nov 1.