PMID- 30386332
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20191002
LR  - 20191002
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Aquaporin 9 Contributes to the Maturation Process and Inflammatory Cytokine 
      Secretion of Murine Dendritic Cells.
PG  - 2355
LID - 10.3389/fimmu.2018.02355 [doi]
LID - 2355
AB  - Dendritic cells (DCs) are the most potent antigen-presenting cells able to 
      trigger the adaptive immune response to specific antigens. When non-self-antigens 
      are captured, DCs switch from an "immature" to a "mature" state to fulfill their 
      function. Among the several surface proteins involved in DCs maturation, the role 
      of aquaporins (AQPs) is still poorly understood. Here we investigated the 
      expression profile of Aqps in murine bone marrow derived dendritic cells (BMDCs). 
      Among the Aqps analyzed, Aqp9 was the most expressed by DCs. Its expression level 
      was significantly upregulated 6 h following LPS exposure. Chemical inhibition of 
      Aqp9 led to a decreased inflammatory cytokines secretion. BMDCs from AQP9-KO mice 
      release lower amount of inflammatory cytokines and chemokines and increased 
      release of IL-10. Despite the reduced release of inflammatory cytokines, Aqp9-KO 
      mice were not protected from DSS induced colitis. All together, our data indicate 
      that AQP9 blockade can be an efficient strategy to reduce DCs inflammatory 
      response but it is not sufficient to protect from acute inflammatory insults such 
      as DSS induced colitis.
FAU - De Santis, Stefania
AU  - De Santis S
AD  - National Institute of Gastroenterology "S. de Bellis", Research Hospital, 
      Castellana Grotte, Italy.
AD  - Department of Pharmacy, University of Salerno, Fisciano, Italy.
AD  - Pineta Grande Hospital, Castelvolturno, Italy.
FAU - Serino, Grazia
AU  - Serino G
AD  - National Institute of Gastroenterology "S. de Bellis", Research Hospital, 
      Castellana Grotte, Italy.
FAU - Fiorentino, Maria R
AU  - Fiorentino MR
AD  - Harvard Medical School Division of Pediatric Gastroenterology and Nutrition and 
      Mucosal Immunology and Biology Research Center, Massachusetts General Hospital 
      for Children, Boston, MA, United States.
FAU - Galleggiante, Vanessa
AU  - Galleggiante V
AD  - National Institute of Gastroenterology "S. de Bellis", Research Hospital, 
      Castellana Grotte, Italy.
FAU - Gena, Patrizia
AU  - Gena P
AD  - Department of Medicine and Surgery and Dentistry, "Scuola Medica Salernitana", 
      University of Salerno, Salerno, Italy.
FAU - Verna, Giulio
AU  - Verna G
AD  - National Institute of Gastroenterology "S. de Bellis", Research Hospital, 
      Castellana Grotte, Italy.
FAU - Liso, Marina
AU  - Liso M
AD  - National Institute of Gastroenterology "S. de Bellis", Research Hospital, 
      Castellana Grotte, Italy.
FAU - Massaro, Monica
AU  - Massaro M
AD  - National Institute of Gastroenterology "S. de Bellis", Research Hospital, 
      Castellana Grotte, Italy.
FAU - Lan, Jinggang
AU  - Lan J
AD  - Harvard Medical School Division of Pediatric Gastroenterology and Nutrition and 
      Mucosal Immunology and Biology Research Center, Massachusetts General Hospital 
      for Children, Boston, MA, United States.
FAU - Troisi, Jacopo
AU  - Troisi J
AD  - Department of Medicine and Surgery and Dentistry, "Scuola Medica Salernitana", 
      University of Salerno, Salerno, Italy.
AD  - Theoreo srl-Spin-off Company of the University of Salerno, Salerno, Italy.
FAU - Cataldo, Ilaria
AU  - Cataldo I
AD  - Department of Medicine and Surgery and Dentistry, "Scuola Medica Salernitana", 
      University of Salerno, Salerno, Italy.
FAU - Bertamino, Alessia
AU  - Bertamino A
AD  - Department of Pharmacy, University of Salerno, Fisciano, Italy.
FAU - Pinto, Aldo
AU  - Pinto A
AD  - Department of Pharmacy, University of Salerno, Fisciano, Italy.
FAU - Campiglia, Pietro
AU  - Campiglia P
AD  - Department of Pharmacy, University of Salerno, Fisciano, Italy.
AD  - European Biomedical Research Institute of Salerno, Salerno, Italy.
FAU - Santino, Angelo
AU  - Santino A
AD  - Institute of Sciences of Food Production C.N.R., Unit of Lecce, Lecce, Italy.
FAU - Giannelli, Gianluigi
AU  - Giannelli G
AD  - National Institute of Gastroenterology "S. de Bellis", Research Hospital, 
      Castellana Grotte, Italy.
FAU - Fasano, Alessio
AU  - Fasano A
AD  - Harvard Medical School Division of Pediatric Gastroenterology and Nutrition and 
      Mucosal Immunology and Biology Research Center, Massachusetts General Hospital 
      for Children, Boston, MA, United States.
AD  - European Biomedical Research Institute of Salerno, Salerno, Italy.
FAU - Calamita, Giuseppe
AU  - Calamita G
AD  - Department of Medicine and Surgery and Dentistry, "Scuola Medica Salernitana", 
      University of Salerno, Salerno, Italy.
FAU - Chieppa, Marcello
AU  - Chieppa M
AD  - National Institute of Gastroenterology "S. de Bellis", Research Hospital, 
      Castellana Grotte, Italy.
AD  - Department of Pharmacy, University of Salerno, Fisciano, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181016
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
EIN - Front Immunol. 2019 Feb 25;10:216. PMID: 30873153
PMC - PMC6198254
OTO - NOTNLM
OT  - AQP9
OT  - dendritic cells
OT  - glycerol
OT  - il-12
OT  - inflammation
EDAT- 2018/11/06 06:00
MHDA- 2018/11/06 06:01
PMCR- 2018/01/01
CRDT- 2018/11/03 06:00
PHST- 2018/05/28 00:00 [received]
PHST- 2018/09/24 00:00 [accepted]
PHST- 2018/11/03 06:00 [entrez]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2018/11/06 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.02355 [doi]
PST - epublish
SO  - Front Immunol. 2018 Oct 16;9:2355. doi: 10.3389/fimmu.2018.02355. eCollection 
      2018.