PMID- 30388625
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240405
IS  - 2162-2531 (Print)
IS  - 2162-2531 (Electronic)
IS  - 2162-2531 (Linking)
VI  - 13
DP  - 2018 Dec 7
TI  - Genetic Strategies for HIV Treatment and Prevention.
PG  - 514-533
LID - S2162-2531(18)30262-2 [pii]
LID - 10.1016/j.omtn.2018.09.018 [doi]
AB  - Conventional HIV gene therapy approaches are based on engineering HIV target 
      cells that are non-permissive to viral replication. However, expansion of 
      gene-modified HIV target cells has been limited in patients. Alternative genetic 
      strategies focus on generating gene-modified producer cells that secrete 
      antiviral proteins (AVPs). The secreted AVPs interfere with HIV entry, and, 
      therefore, they extend the protection against infection to unmodified HIV target 
      cells. Since any cell type can potentially secrete AVPs, hematopoietic and 
      non-hematopoietic cell lineages can function as producer cells. Secretion of AVPs 
      from non-hematopoietic cells opens the possibility of using a genetic approach 
      for HIV prevention. Another strategy aims at modifying cytotoxic T cells to 
      selectively target and eliminate infected cells. This review provides an overview 
      of the different genetic approaches for HIV treatment and prevention.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Falkenhagen, Alexander
AU  - Falkenhagen A
AD  - Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; 
      Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, 
      ON, Canada.
FAU - Joshi, Sadhna
AU  - Joshi S
AD  - Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; 
      Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, 
      ON, Canada. Electronic address: sadhna.joshi.sukhwal@utoronto.ca.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180929
PL  - United States
TA  - Mol Ther Nucleic Acids
JT  - Molecular therapy. Nucleic acids
JID - 101581621
PMC - PMC6205348
OTO - NOTNLM
OT  - HIV
OT  - antiviral proteins
OT  - genetic therapies
EDAT- 2018/11/06 06:00
MHDA- 2018/11/06 06:01
PMCR- 2018/09/29
CRDT- 2018/11/03 06:00
PHST- 2017/11/30 00:00 [received]
PHST- 2018/08/28 00:00 [revised]
PHST- 2018/09/02 00:00 [accepted]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2018/11/06 06:01 [medline]
PHST- 2018/11/03 06:00 [entrez]
PHST- 2018/09/29 00:00 [pmc-release]
AID - S2162-2531(18)30262-2 [pii]
AID - 10.1016/j.omtn.2018.09.018 [doi]
PST - ppublish
SO  - Mol Ther Nucleic Acids. 2018 Dec 7;13:514-533. doi: 10.1016/j.omtn.2018.09.018. 
      Epub 2018 Sep 29.