PMID- 30388935
OWN - NLM
STAT- MEDLINE
DCOM- 20200612
LR  - 20200612
IS  - 1541-1087 (Electronic)
IS  - 0731-5724 (Linking)
VI  - 38
IP  - 2
DP  - 2019 Feb
TI  - Role of Vitamin D and Its Receptors in the Pathophysiology of Chronic 
      Rhinosinusitis.
PG  - 108-118
LID - 10.1080/07315724.2018.1503102 [doi]
AB  - OBJECTIVES: Chronic rhinosinusitis (CRS) is a disease that represents a 
      challenging therapeutic problem. Vitamin D and its receptors (VDR) are involved 
      in the regulation of the immune system and may play role in CRS. Objectives of 
      this study were to assess the relationships between the total concentration of 
      vitamin D (25VD3) in sera, vitamin D receptor (VDR) expression, 1alpha-hydroxylase 
      expression, and clinical data, including age, gender, Sino-Nasal Outcome Test 
      (SNOT-22), computerized tomography (CT) scan, allergy status, and vitamin D 
      supplementation in CRS patients with (CRSwNP) and without nasal polyps (CRSsNP), 
      and in a control group. METHODS: The studied group comprised 52 patients with CRS 
      without nasal polyps (sNP), 55 with CRS with nasal polyps (wNP), and 59 in the 
      control group. The endpoints were determined by appropriate methods. We conducted 
      immunohistochemical staining of gathered tissue from the ostiomeatal complex for 
      determination of VDR and 1alpha-hydroxylase. Analytical results were compared with 
      clinical data as already noted. RESULTS: A decrease in VDR nuclear staining 
      occurred in CRS patients as compared to controls. Insignificant differences were 
      observed in 1alpha-hydroxylase, expression in all studied groups, while VDR and 
      cytochrome CYP27B1 protein expression (1alpha-hydroxylase) correlated with clinical 
      data. CONCLUSIONS: The data provide evidence that indicates that vitamin D and 
      its receptor and enzymes may play a role in CRS.
FAU - Tomaszewska, Malgorzata
AU  - Tomaszewska M
AD  - a Department of Otorhinolaryngology , Faculty of Medicine and Dentistry, Medical 
      University of Warsaw , Poland.
FAU - Sarnowska, Elzbieta
AU  - Sarnowska E
AD  - b Department of Molecular and Translational Oncology , Maria 
      Sklodowska-Curie-Institute Oncology Center , Warsaw , Poland.
FAU - Rusetska, Natalia
AU  - Rusetska N
AD  - b Department of Molecular and Translational Oncology , Maria 
      Sklodowska-Curie-Institute Oncology Center , Warsaw , Poland.
FAU - Kowalik, Katarzyna
AU  - Kowalik K
AD  - a Department of Otorhinolaryngology , Faculty of Medicine and Dentistry, Medical 
      University of Warsaw , Poland.
FAU - Sierdzinski, Janusz
AU  - Sierdzinski J
AD  - c Department of Medical Informatics and Telemedicine , Medical University of 
      Warsaw , Warsaw , Poland.
FAU - Siedlecki, Janusz A
AU  - Siedlecki JA
AD  - b Department of Molecular and Translational Oncology , Maria 
      Sklodowska-Curie-Institute Oncology Center , Warsaw , Poland.
FAU - Badmaev, Vladimir
AU  - Badmaev V
AD  - d American Medical Holdings Inc , Staten Island , New York , USA.
FAU - Stohs, Sidney J
AU  - Stohs SJ
AD  - e School of Pharmacy and Health Professions , Creighton University , Omaha , 
      Nebraska , USA.
FAU - Popko, Mariola
AU  - Popko M
AD  - a Department of Otorhinolaryngology , Faculty of Medicine and Dentistry, Medical 
      University of Warsaw , Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181102
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (VDR protein, human)
RN  - 1406-16-2 (Vitamin D)
RN  - EC 1.14.- (Steroid Hydroxylases)
RN  - EC 1.14.- (vitamin D 1-alpha hydroxylase)
RN  - EC 1.14.15.18 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase)
RN  - EC 1.14.15.18 (CYP27B1 protein, human)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/blood
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Calcifediol/blood
MH  - Chronic Disease
MH  - Dietary Supplements
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasal Polyps/*blood/complications
MH  - Prospective Studies
MH  - Receptors, Calcitriol/*blood
MH  - Rhinitis/*blood/complications/therapy
MH  - Sinusitis/*blood/complications/therapy
MH  - Steroid Hydroxylases/blood
MH  - Vitamin D/administration & dosage/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - 1alpha-hydroxylase
OT  - CYP27B1
OT  - Vitamin D
OT  - chronic rhinosinusitis
OT  - clinical data
OT  - sinonasal mucosa
OT  - vitamin D receptor
EDAT- 2018/11/06 06:00
MHDA- 2020/06/13 06:00
CRDT- 2018/11/04 06:00
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2020/06/13 06:00 [medline]
PHST- 2018/11/04 06:00 [entrez]
AID - 10.1080/07315724.2018.1503102 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 2019 Feb;38(2):108-118. doi: 10.1080/07315724.2018.1503102. Epub 
      2018 Nov 2.