PMID- 30389165
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20190613
IS  - 1879-3592 (Electronic)
IS  - 1383-5718 (Linking)
VI  - 836
IP  - Pt A
DP  - 2018 Dec
TI  - Lessons from the accident with (137)Cesium in Goiania, Brazil: Contributions to 
      biological dosimetry in case of human exposure to ionizing radiation.
PG  - 72-77
LID - S1383-5718(18)30077-9 [pii]
LID - 10.1016/j.mrgentox.2018.05.019 [doi]
AB  - Human exposure to ionizing radiation has increased over time, mainly due to 
      medical applications, occupational and environmental exposure, as well as 
      accidents involving radioactive materials. In September 1987, an accident with 
      (137)Cesium occurred in Goiania city, Brazil; the accident started with the 
      removal of a 50.9-TBq (137)Cesium source from an abandoned radiotherapy unit. 
      Among the radiation-exposed victims, at least 50 individuals showed symptoms of 
      whole-body and local acute irradiation, and also external or internal 
      contamination. In this report, the purpose was to review and summarize the main 
      results of cytogenetic studies carried out with victims of (137)Cesium, for blood 
      collection performed shortly after the accident, and following several years 
      post-exposure. The importance of dose estimates by biological dosimetry is 
      highlighted, and also several lessons that were learned from the initial to 
      follow-up (7-10 years after the accident) studies, mainly by applying the 
      fluorescence in situ hybridization (FISH) method. A relevant aspect discussed on 
      the basis of the results obtained in those studies refers to the incidence of 
      chromosomal translocations, which were directly compared to the initial 
      frequencies of dicentrics that were previously used to estimate the absorbed 
      doses. In general, translocation frequencies were two to three times lower than 
      the dicentric frequencies, and the differences were dose-dependent. Furthermore, 
      regarding attempts to perform retrospective dosimetry (10 years post-accident), 
      the dose estimates using translocation frequencies for victims of (137)Cesium 
      indicate the feasibility of this approach only for low level exposure (below 
      0.5 Gy), while for higher doses there are some limitations, and the requirement 
      to apply appropriate correction factors, which were discussed on the basis of 
      literature data. Apart of this, in general terms, important aspects to be 
      mentioned refer to the need for better care and control of radioactive devices, 
      as well as adequate education programs for professionals and also the population.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Sakamoto-Hojo, Elza Tiemi
AU  - Sakamoto-Hojo ET
AD  - Department of Biology, Faculty of Philosophy, Sciences and Letters at Ribeirao 
      Preto, Brazil; Department of Genetics, Ribeirao Preto Medical School, University 
      of Sao Paulo - USP, Av Bandeirantes 3900, 14040-901, Ribeirao Preto, SP, Brazil. 
      Electronic address: etshojo@usp.br.
LA  - eng
PT  - Journal Article
DEP - 20180528
PL  - Netherlands
TA  - Mutat Res Genet Toxicol Environ Mutagen
JT  - Mutation research. Genetic toxicology and environmental mutagenesis
JID - 101632149
RN  - 0 (Cesium Radioisotopes)
RN  - 4T2E65IAR7 (Cesium-137)
SB  - IM
MH  - Cesium Radioisotopes/*adverse effects
MH  - Humans
MH  - Radiation Dosage
MH  - Radiation Exposure/*adverse effects
MH  - *Radiation, Ionizing
MH  - *Radioactive Hazard Release
MH  - Radiometry/*methods
MH  - Retrospective Studies
MH  - Translocation, Genetic/*radiation effects
OTO - NOTNLM
OT  - (137)Cesium
OT  - Biological dosimetry
OT  - Chromosomal aberrations
OT  - Dicentrics
OT  - Ionizing radiation
OT  - Translocations
EDAT- 2018/11/06 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/11/04 06:00
PHST- 2018/02/21 00:00 [received]
PHST- 2018/05/16 00:00 [revised]
PHST- 2018/05/26 00:00 [accepted]
PHST- 2018/11/04 06:00 [entrez]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
AID - S1383-5718(18)30077-9 [pii]
AID - 10.1016/j.mrgentox.2018.05.019 [doi]
PST - ppublish
SO  - Mutat Res Genet Toxicol Environ Mutagen. 2018 Dec;836(Pt A):72-77. doi: 
      10.1016/j.mrgentox.2018.05.019. Epub 2018 May 28.