PMID- 30389354
OWN - NLM
STAT- MEDLINE
DCOM- 20200304
LR  - 20210109
IS  - 2212-4934 (Electronic)
IS  - 2212-4926 (Print)
IS  - 2212-4926 (Linking)
VI  - 71
DP  - 2019 Jan
TI  - Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer.
PG  - 141-146
LID - S2212-4926(18)30151-9 [pii]
LID - 10.1016/j.jbior.2018.10.005 [doi]
AB  - Extensive research conducted in the last three decades has identified the roles 
      for the main bioactive sphingolipids, namely ceramide, sphingosine, and 
      sphingosine 1-phosphate (S1P) as key regulators of cellular homeostasis, growth 
      and death. One of the major groups of enzymes in the ceramide pathway, 
      ceramidases, converts ceramide into sphingosine and fatty acids, with sphingosine 
      being further metabolized to S1P. Thus, these enzymes play important roles in the 
      network controlling the functions associated with these bioactive sphingolipids. 
      Among the family of ceramidases, neutral ceramidase (nCDase), which is named 
      according to its optimal pH for catalytic activity, has received increased 
      attention in the last decade. The goal of this review is to provide a brief 
      background on bioactive sphingolipids and the ceramidases. We then describe more 
      recent advances on nCDase, specifically the resolution of its crystal structure 
      and understanding its roles in cell biology and physiology.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Coant, Nicolas
AU  - Coant N
AD  - Health Science Center, Stony Brook University, 100 Nicolls Road, T15, 023, 11794, 
      Stony Brook, NY, USA. Electronic address: Nicolas.Coant@stonybrookmedicine.edu.
FAU - Hannun, Yusuf A
AU  - Hannun YA
AD  - Health Science Center, Stony Brook University, 100 Nicolls Road, L4, 182, 11794, 
      Stony Brook, NY, USA. Electronic address: Yusuf.Hannun@stonybrookmedicine.edu.
LA  - eng
GR  - P01 CA097132/CA/NCI NIH HHS/United States
GR  - R01 CA172517/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20181026
PL  - England
TA  - Adv Biol Regul
JT  - Advances in biological regulation
JID - 101572336
RN  - 0 (Lysophospholipids)
RN  - 0 (Neoplasm Proteins)
RN  - 26993-30-6 (sphingosine 1-phosphate)
RN  - EC 3.5.1.23 (ASAH2 protein, human)
RN  - EC 3.5.1.23 (Neutral Ceramidase)
RN  - NGZ37HRE42 (Sphingosine)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Lysophospholipids/*metabolism
MH  - Neoplasm Proteins/*metabolism
MH  - Neoplasms/*metabolism/pathology
MH  - Neutral Ceramidase/*metabolism
MH  - *Signal Transduction
MH  - Sphingosine/*analogs & derivatives/metabolism
PMC - PMC6347532
MID - NIHMS1511264
OTO - NOTNLM
OT  - Akt
OT  - Cancer
OT  - Catalysis
OT  - Cell proliferation
OT  - Sphingolipids
OT  - Sphingosine
OT  - Structure
COIS- We declare no conflict of interest.
EDAT- 2018/11/06 06:00
MHDA- 2020/03/05 06:00
PMCR- 2020/01/01
CRDT- 2018/11/04 06:00
PHST- 2018/10/17 00:00 [received]
PHST- 2018/10/23 00:00 [revised]
PHST- 2018/10/23 00:00 [accepted]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2020/03/05 06:00 [medline]
PHST- 2018/11/04 06:00 [entrez]
PHST- 2020/01/01 00:00 [pmc-release]
AID - S2212-4926(18)30151-9 [pii]
AID - 10.1016/j.jbior.2018.10.005 [doi]
PST - ppublish
SO  - Adv Biol Regul. 2019 Jan;71:141-146. doi: 10.1016/j.jbior.2018.10.005. Epub 2018 
      Oct 26.