PMID- 30390251
OWN - NLM
STAT- MEDLINE
DCOM- 20190724
LR  - 20211204
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1088
DP  - 2018
TI  - mTOR Signaling Pathway and Protein Synthesis: From Training to Aging and Muscle 
      Autophagy.
PG  - 139-151
LID - 10.1007/978-981-13-1435-3_7 [doi]
AB  - In muscle tissue there is a balance between the processes muscle synthesis and 
      degradation. The mammalian target of rapamycin (mTOR) signaling pathway plays a 
      critical role in regulating protein synthesis in order to maintain muscular 
      protein turnover and trophism. Studies have shown that both down- and 
      upregulation mechanisms are involved in this process in a manner dependent on 
      stimulus and cellular conditions. Additionally, mTOR signaling has recently been 
      implicated in several physiological conditions related to cell survival, such as 
      self-digestion (autophagy), energy production, and the preservation of cellular 
      metabolic balance over the lifespan. Here we briefly describe the mTOR structure 
      and its regulatory protein synthesis pathway. Furthermore, the role of mTOR 
      protein in autophagy, aging, and mitochondrial function in muscle tissue is 
      presented.
FAU - Ilha, Jocemar
AU  - Ilha J
AD  - Programa de Pos-Graduacao em Fisioterapia (PPGFt), Departamento de Fisioterapia, 
      Centro de Ciencias da Saude e do Esporte (CEFID), Universidade do Estado de Santa 
      Catarina (UDESC), Florianopolis, Santa Catarina, Brazil. jocemar.ilha@udesc.br.
FAU - do Espirito-Santo, Caroline Cunha
AU  - do Espirito-Santo CC
AD  - Programa de Pos-Graduacao em Fisioterapia (PPGFt), Departamento de Fisioterapia, 
      Centro de Ciencias da Saude e do Esporte (CEFID), Universidade do Estado de Santa 
      Catarina (UDESC), Florianopolis, Santa Catarina, Brazil.
AD  - Laboratorio Neurobiologia da Dor e Inflamacao (LANDI), Departamento de Ciencias 
      Fisiologicas, Universidade Federal de Santa Catarina (UFSC), Florianopolis, Santa 
      Catarina, Brazil.
FAU - de Freitas, Gabriel Ribeiro
AU  - de Freitas GR
AD  - Programa de Pos-Graduacao em Fisioterapia (PPGFt), Departamento de Fisioterapia, 
      Centro de Ciencias da Saude e do Esporte (CEFID), Universidade do Estado de Santa 
      Catarina (UDESC), Florianopolis, Santa Catarina, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
MH  - *Aging
MH  - *Autophagy
MH  - Humans
MH  - Muscles/*physiology
MH  - *Protein Biosynthesis
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - Muscle autophagy
OT  - Muscle trophism
OT  - Muscular synthesis
OT  - mTOR pathway
EDAT- 2018/11/06 06:00
MHDA- 2019/07/25 06:00
CRDT- 2018/11/04 06:00
PHST- 2018/11/04 06:00 [entrez]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2019/07/25 06:00 [medline]
AID - 10.1007/978-981-13-1435-3_7 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2018;1088:139-151. doi: 10.1007/978-981-13-1435-3_7.