PMID- 30390442
OWN - NLM
STAT- MEDLINE
DCOM- 20190531
LR  - 20190531
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 99
DP  - 2019 Jan
TI  - Dual-hormone regulation of psychopathy: Evidence from mass spectrometry.
PG  - 243-250
LID - S0306-4530(18)30484-0 [pii]
LID - 10.1016/j.psyneuen.2018.09.006 [doi]
AB  - Previous work suggests that testosterone and cortisol interactively predict 
      psychopathy. This effect represents a reversal of the established dual-hormone 
      hypothesis, whereby testosterone is positively correlated with psychopathic 
      traits, but only among individuals with elevated cortisol concentrations. This 
      study aims to replicate the dual-hormone moderation of psychopathy in two 
      independent samples. Enzyme-linked immunoassays (ELISAs) were used to assess 
      cortisol across both samples and testosterone in Sample 1 (n = 165, 100% males). 
      To address recent criticism of ELISAs and potentially extend these findings to 
      women, testosterone concentrations were determined by liquid chromatography 
      tandem mass spectrometry (LC-MS/MS) in Sample 2 (n = 213, 44.1% males). We found 
      conflicting evidence of the dual-hormone moderation of psychopathic traits. 
      Although results were non-significant in Sample 1, a reversal of the dual-hormone 
      hypothesis was found in Sample 2, in which testosterone was positively correlated 
      with psychopathic traits, but only among individuals with high cortisol. This 
      replication provides mixed support for less common reversals to the dual-hormone 
      hypothesis. These findings emphasize the importance of using LC-MS/MS to measure 
      testosterone and adds to the growing body of work on the relationship between 
      hormones and psychopathology in general.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Roy, Ashlin R K
AU  - Roy ARK
AD  - 100 William T. Morrissey Blvd, Department of Psychology, University of 
      Massachusetts Boston, Boston, MA, United States. Electronic address: 
      ashlin.roy@umb.edu.
FAU - Cook, Terence
AU  - Cook T
AD  - 100 William T. Morrissey Blvd, Department of Psychology, University of 
      Massachusetts Boston, Boston, MA, United States. Electronic address: 
      terence.cook001@umb.edu.
FAU - Carre, Justin M
AU  - Carre JM
AD  - 100 College Drive, Department of Psychology, Nipissing University, North Bay, ON 
      P1B 8L7, Canada. Electronic address: justinca@nipissingu.ca.
FAU - Welker, Keith M
AU  - Welker KM
AD  - 100 William T. Morrissey Blvd, Department of Psychology, University of 
      Massachusetts Boston, Boston, MA, United States. Electronic address: 
      keith.welker@umb.edu.
LA  - eng
PT  - Journal Article
DEP - 20180913
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 3XMK78S47O (Testosterone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Antisocial Personality Disorder/*metabolism
MH  - Chromatography, Liquid/methods
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Humans
MH  - Hydrocortisone/analysis/*physiology
MH  - Male
MH  - Saliva/chemistry
MH  - Tandem Mass Spectrometry/methods
MH  - Testosterone/analysis/*physiology
OTO - NOTNLM
OT  - Cortisol
OT  - Hormones
OT  - Liquid chromatography
OT  - Mass spectrometry
OT  - Psychopathy
OT  - Testosterone
EDAT- 2018/11/06 06:00
MHDA- 2019/06/01 06:00
CRDT- 2018/11/04 06:00
PHST- 2018/05/24 00:00 [received]
PHST- 2018/08/17 00:00 [revised]
PHST- 2018/09/07 00:00 [accepted]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2019/06/01 06:00 [medline]
PHST- 2018/11/04 06:00 [entrez]
AID - S0306-4530(18)30484-0 [pii]
AID - 10.1016/j.psyneuen.2018.09.006 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2019 Jan;99:243-250. doi: 
      10.1016/j.psyneuen.2018.09.006. Epub 2018 Sep 13.