PMID- 30391979
OWN - NLM
STAT- MEDLINE
DCOM- 20190618
LR  - 20200225
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 20
IP  - 5
DP  - 2018 Nov
TI  - Blood type B antigen is associated with worse New York Heart Association 
      classification in male patients with hypertrophic cardiomyopathy.
PG  - 258-265
LID - 10.14744/AnatolJCardiol.2018.40607 [doi]
AB  - OBJECTIVE: ABO blood type is associated with cardiovascular diseases. Several 
      studies have suggested sex-related differences in both hypertrophic 
      cardiomyopathy (HCM) clinical features and ABO blood type. However, few data are 
      available regarding the relationship between ABO blood type and HCM clinical 
      features. We aimed to analyze the relationship between ABO blood type and HCM 
      clinical features, and the potential effects of sex on these relationship. 
      METHODS: A total of 549 patients with HCM were enrolled consecutively. Left 
      ventricular outflow tract gradients at rest (LOVTG-R) were measured by 
      echocardiography. Left ventricular end-diastolic dimension, interventricular 
      septum, left ventricular ejection fraction (LVEF), left ventricular end-diastolic 
      volume (LVEDV), left ventricular end-systolic volume (LVESV), and left 
      ventricular mass (LVM) were assessed using cardiovascular magnetic resonance 
      imaging. RESULTS: Compared with the non-B antigen group, patients with B antigen 
      had significantly higher LOVTG-R and LVEF values, worse New York Heart 
      Association (NYHA) classification, lower left ventricular volume index values, as 
      well as no difference in LVM index values. After adjustments for sex, male 
      patients with B antigen still had higher LOVTG-R values and frequency of NYHA 
      classification III/IV as well as lower LVEDV and LVESV index values. These 
      differences were not present in female patients. Additionally, patients with NYHA 
      classification III/IV had lower LVEDV index values. CONCLUSION: In males, not 
      females, patients with HCM with blood type B antigens exhibited worse cardiac 
      functional capacity, higher LOVTG-R values, and lower left ventricular volume 
      index values. These relationships are a potential indicator for clinical 
      prevention. We speculate that rehydration is more efficient in relieving symptoms 
      in male patients with HCM with B antigens.
FAU - Jiang, Xiaowei
AU  - Jiang X
FAU - Yuan, Jiansong
AU  - Yuan J
FAU - Cui, Jingang
AU  - Cui J
FAU - Liu, Shengwen
AU  - Liu S
FAU - Hu, Fenghuan
AU  - Hu F
FAU - Yang, Weixian
AU  - Yang W
FAU - Tian, Hongwei
AU  - Tian H
FAU - Qiao, Shubin
AU  - Qiao S
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing -China. qsbfw@sina.com.
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
RN  - 0 (ABO Blood-Group System)
RN  - 0 (Antigens)
RN  - 0 (Biomarkers)
SB  - IM
MH  - ABO Blood-Group System/*immunology
MH  - Antigens/*blood
MH  - Biomarkers/*blood
MH  - Cardiomyopathy, Hypertrophic/*blood/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Societies, Medical
PMC - PMC6280276
COIS- Conflict of interest: None declared.
EDAT- 2018/11/06 06:00
MHDA- 2019/06/19 06:00
PMCR- 2018/11/01
CRDT- 2018/11/05 06:00
PHST- 2018/11/05 06:00 [entrez]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2019/06/19 06:00 [medline]
PHST- 2018/11/01 00:00 [pmc-release]
AID - AJC-20-258 [pii]
AID - 10.14744/AnatolJCardiol.2018.40607 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2018 Nov;20(5):258-265. doi: 
      10.14744/AnatolJCardiol.2018.40607.