PMID- 30392491 OWN - NLM STAT- MEDLINE DCOM- 20200728 LR - 20231115 IS - 1469-8978 (Electronic) IS - 0033-2917 (Linking) VI - 49 IP - 13 DP - 2019 Oct TI - Jumping to conclusions at first onset of psychosis predicts longer admissions, more compulsory admissions and police involvement over the next 4 years: the GAP study. PG - 2256-2266 LID - 10.1017/S0033291718003197 [doi] AB - BACKGROUND: Jumping to conclusions (JTC), which is the proneness to require less information before forming beliefs or making a decision, has been related to formation and maintenance of delusions. Using data from the National Institute of Health Research Biomedical Research Centre Genetics and Psychosis (GAP) case-control study of first-episode psychosis (FEP), we set out to test whether the presence of JTC would predict poor clinical outcome at 4 years. METHODS: One-hundred and twenty-three FEP patients were assessed with the Positive and Negative Syndrome Scale (PANSS), Global Assessment of Functioning (GAF) and the probabilistic reasoning 'Beads' Task at the time of recruitment. The sample was split into two groups based on the presence of JTC bias. Follow-up data over an average of 4 years were obtained concerning clinical course and outcomes (remission, intervention of police, use of involuntary treatment - the Mental Health Act (MHA) - and inpatient days). RESULTS: FEP who presented JTC at baseline were more likely during the follow-up period to be detained under the MHA [adjusted OR 15.62, 95% confidence interval (CI) 2.92-83.54, p = 0.001], require intervention by the police (adjusted OR 14.95, 95% CI 2.68-83.34, p = 0.002) and have longer admissions (adjusted IRR = 5.03, 95% CI 1.91-13.24, p = 0.001). These associations were not accounted for by socio-demographic variables, IQ and symptom dimensions. CONCLUSIONS: JTC in FEP is associated with poorer outcome as indicated and defined by more compulsion police intervention and longer periods of admission. Our findings raise the question of whether the implementation of specific interventions to reduce JTC, such as Metacognition Training, may be a useful addition in early psychosis intervention programmes. FAU - Rodriguez, Victoria AU - Rodriguez V AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Ajnakina, Olesya AU - Ajnakina O AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Stilo, Simona A AU - Stilo SA AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Mondelli, Valeria AU - Mondelli V AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Marques, Tiago Reis AU - Marques TR AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Trotta, Antonella AU - Trotta A AD - Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Quattrone, Diego AU - Quattrone D AD - Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Gardner-Sood, Poonam AU - Gardner-Sood P AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Colizzi, Marco AU - Colizzi M AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Wiffen, Benjamin D AU - Wiffen BD AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Dazzan, Paola AU - Dazzan P AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Di Forti, Marta AU - Di Forti M AD - Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Falcone, M Aurora AU - Falcone MA AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - David, Anthony S AU - David AS AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Murray, Robin M AU - Murray RM AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. LA - eng GR - MR/M008436/1/MRC_/Medical Research Council/United Kingdom GR - MRF_C0439/MRF/MRF/United Kingdom GR - DH_/Department of Health/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20181105 PL - England TA - Psychol Med JT - Psychological medicine JID - 1254142 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Case-Control Studies MH - Commitment of Mentally Ill/*statistics & numerical data MH - Decision Making MH - Delusions MH - Female MH - Humans MH - Male MH - Middle Aged MH - Patient Admission MH - Police MH - Psychiatric Status Rating Scales MH - Psychotic Disorders/*therapy MH - United Kingdom MH - Young Adult OTO - NOTNLM OT - Clinical outcome OT - first-episode psychosis OT - jumping to conclusions OT - psychosis OT - reasoning bias EDAT- 2018/11/06 06:00 MHDA- 2020/07/29 06:00 CRDT- 2018/11/06 06:00 PHST- 2018/11/06 06:00 [pubmed] PHST- 2020/07/29 06:00 [medline] PHST- 2018/11/06 06:00 [entrez] AID - S0033291718003197 [pii] AID - 10.1017/S0033291718003197 [doi] PST - ppublish SO - Psychol Med. 2019 Oct;49(13):2256-2266. doi: 10.1017/S0033291718003197. Epub 2018 Nov 5.